| Description |
1 online resource (774 p.) |
| Contents |
Intro -- Foreword -- Preface -- Contents -- Editor and Contributors -- Part I: Pharmaceutical Innovation and Research -- 1: Innovation in Stabilization of Biopharmaceuticals -- 1.1 Introduction -- 1.2 Stability Is the Major Concern for Biopharmaceuticals -- 1.3 Mechanisms of Protein Degradation -- 1.3.1 Self-Assembly of Monomeric Protein -- 1.3.2 Aggregation of Conformationally Altered Monomers -- 1.3.3 Aggregation of Chemically Modified Monomer -- 1.3.4 Nucleation-Mediated Aggregation -- 1.3.5 Surface-Induced Aggregation -- 1.4 Instability of Protein Drugs -- 1.4.1 Denaturation |
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1.4.2 Aggregation -- 1.4.3 Precipitation -- 1.4.4 Chemical Instability -- 1.5 Novel Stabilizers -- 1.5.1 Immobilization of Enzymes -- 1.5.2 Aptamers -- 1.6 Outlook -- References -- 2: Concepts in Pharmacogenomics: Tools and Applications -- 2.1 Background -- 2.2 Pharmacogenomics Concept -- 2.3 History -- 2.4 Inter-individual Differences in Therapeutic Response to Drugs -- 2.5 Methods Used in Pharmacogenomics Research -- 2.6 OMICS Tools Used in Pharmacogenomics Research -- 2.6.1 Transcriptomics -- 2.6.2 Pharmacometabolomics -- 2.6.3 Proteomics -- 2.6.4 Genomics -- 2.7 Applications |
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2.7.1 Precision Medicine -- 2.7.2 Drug Discovery and Development -- References -- 3: Pharmacogenetics: A New Approach for the Selection of the Right Drug -- 3.1 Introduction -- 3.2 History of Pharmacogenomics -- 3.2.1 In the Early 1930s -- 3.2.2 In the Late 1930s -- 3.2.3 In the Period of the 1960s -- 3.2.4 The Present Scenario -- 3.3 Role of Pharmacogenomics in Pharmacokinetics and Pharmacodynamics -- 3.3.1 Pharmacokinetic Interactions -- 3.3.2 Pharmacodynamic Interaction -- 3.4 Investigation of Pharmacogenome -- 3.4.1 First-Generation Sequencers of DNA |
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3.4.2 The Beginning of High Throughput-Next-Generation Sequencing (HT-NGS) -- 3.4.3 HT-NGS Platforms of the Second Generation -- 3.4.4 HT-NGS Platforms of the Third Generation -- 3.4.5 Sequencer for Single Molecules in Real-Time (SMRTTM) -- 3.4.6 HeliScopeTM -- 3.4.7 RNA Polymerase (RNAP) Sequencer -- 3.4.8 DNA Sequencer Using Nanopores -- 3.4.9 VisiGen Biotechnologies -- 3.4.10 Technology for Multiplex Polony -- 3.5 Clinical Application of Pharmacogenomics -- 3.5.1 Proton Pump Inhibitors (PPIs) -- 3.5.2 Codeine -- 3.5.3 Carbamazepine -- 3.5.4 Allopurinol -- 3.5.5 Dapsone -- 3.5.6 Asparaginase |
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3.6 Conclusion -- References -- 4: Meeting the Unmet Challenges of Pharmaceutical Research Using Artificial Intelligence -- 4.1 Introduction -- 4.2 AI in the Lifecycle of Pharmaceutical Product -- 4.2.1 In Drug Discovery -- 4.2.2 Forecasting of Physicochemical Properties -- 4.2.3 Forecasting of Pharmacological Activity -- 4.2.4 In Pharmaceutical Product Development -- 4.3 Artificial Neural Network -- 4.3.1 ANN vs. Human Brain -- 4.3.2 Theory of ANN -- 4.3.3 The Architecture of ANNs -- 4.3.4 Training -- 4.3.5 Working -- 4.4 Fuzzy Logic -- 4.4.1 Theory of Fuzzy Logic |
| Summary |
This book covers several important aspects of pharmaceutical research and innovations. It presents important topics on drug delivery, novel microsponge, nanocrystals, polymeric nanoparticles, peptide synthesis, biopharmaceuticals, pharmacodynamics, yeast flocculation, neuromodulators, innovative drug discovery, pharmacoinformatics, aminoquinoline, thiourea crystals for API synthesis, FDCs and formulations research, ayurveda and natural products, and innovations to militate anti-microbial resistance (AMR). A chapter is devoted to the applications of Artificial Intelligence and Machine Learning in diverse sectors of the pharmaceutical industry, including drug discovery and development, drug repurposing, and improving pharmaceutical productivity. The book also reviews the role of pharmacogenomics and pharmacogenetics in drug development and precision medicine. Further, the book presents an updated summary of recent advances in the fields of nanomedicines and nano-based drug delivery systems. This book is useful to pharmaceutical sciences students, researchers, educators, and professionals in the pharmaceutical industry to understand the intricacies of new drug research and innovations |
| Notes |
4.4.2 The Architecture of Fuzzy Logic |
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Online resource; title from PDF title page (SpringerLink, viewed September 27, 2023) |
| Subject |
Pharmaceutical technology.
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Pharmaceutical industry -- Technological innovations.
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Drug development -- Technological innovations
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Technology, Pharmaceutical
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Pharmaceutical industry -- Technological innovations.
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Pharmaceutical technology.
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| Form |
Electronic book
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| Author |
Singh, Prati Pal.
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| ISBN |
9789819923021 |
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9819923026 |
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