| Description |
1 online resource |
| Series |
Muscular system--anatomy, functions, and injuries |
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Muscular system--anatomy, functions, and injuries series.
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| Contents |
BASIC BIOLOGY AND CURRENT UNDERSTANDING OF SKELETAL MUSCLE; Library of Congress Cataloging-in-Publication Data; Contents; Preface; Chapter 1: Stem Cell Hierarchies in Muscle Satellite Cells; Abstract; 1. Introduction; 2. Stem Cell Potential of Satellite Cells; 3. Satellite Cell Heterogeneity; 3.1. Evidence of Satellite Cell Heterogeneity among Muscles; 3.2. Evidence of Satellite Cell Heterogeneity within Fibres; 3.3. Molecular Characteristics of Satellite Cell Heterogeneity within Fibres; 3.4. Slow-Dividing Satellite Cell Populations; 3.5. Molecular Characteristics of Slow-Dividing Cells |
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3.6. Slow-Dividing Cells and AgingConclusion; Acknowledgments; References; Chapter 2: Cellular Mechanisms Regulating Protein Metabolism in Skeletal Muscle Cells: Age-Associated Alteration of Intracellular Signaling Governing Protein Synthesis and Degradation; Abstract; Introduction; 1. Translational Control of Muscle Protein Synthesis mTOR -- A Central Regulatory Hub for Protein Synthesis; Regulatory Mechanisms of mTORC1 Activation in Skeletal Muscle -Insulin/IGF-1-Dependent Pathway; Mitogen-Activated Protein Kinase Pathway; Nutrient-Dependent Pathway; Cellular Stresses and mTORC1 Inhibition |
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Energy Status and mTOR Activity2. Molecular Mechanisms Regulating Protein; Degradation in Skeletal Muscle; Transcriptional Regulation of Atrogin1 and MuRF1 Expression; Targeted Substrates of Atrogin1 and MuRF1; 3. Basal Protein Metabolism in Skeletal Muscle; Between Young and Elderly; Age-Associated Anabolic Resistance in Skeletal Muscle; Resistance Exercise; Amino Acids Supplementation; 4. Muscle Protein Degradation during Aging and Chronic Diseases -- Inflammation and Cachexia; Chronic Low -- Grade Inflammation and Sarcopenia; Conclusion; Acknowledgments; References |
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Chapter 3: Biological Actions of Insulin-Like Growth Factor-I (IGF-I) Isoforms and IGF Binding Proteins in Skeletal MuscleAbstract; Introduction; IGF-I Isoforms; IGF Binding Proteins; IGF Binding of IGFBPs; IGFBP Related Proteins; Circulating and Local IGF-I; Modulation of IGFs Action by IGFBPs; IGF-Independent Actions of IGFBPs; Intracellular Signaling in Association with IGF-I and IGFBPs; IGF-I isoforms and Skeletal Muscle Growth; IGFBPs and Skeletal Muscle Growth; Conclusion; References; Chapter 4: An Overview of the Therapeutic Strategies for Preventing Sarcopenia; Abstract |
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Abbreviations1. Introduction; 2. Exercise; 2.1. Resistance Training; 2.2. Endurance Training; 2.3. Combined Exercise; 3. Supplemental Approach; 3.1. Amino Acid Supplementation; 3.2. Creatine Supplementation; 3.3. Ursolic Acid; 3.4. Eicosapentaenoic Acid (EPA); 3.5. Antioxidant Supplementation; 4. Hormonal Supplementation; 4.1. Testosterone; 4.2. Estrogen; 4.3. Growth Hormone (GH); 4.4. Ghrelin; 5. Pharmacological Approach; 5.1. Myostatin Inhibition; 5.2. Angiotensin-Converting Enzyme (ACE) Inhibitors; 5.3. Proteasome Inhibitors; 5.4. Vitamin D; 6. The Other Candidate |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Description based on print version record |
| Subject |
Muscles.
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Muscles -- Physiology.
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Muscles -- Diseases.
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MEDICAL -- Anatomy.
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SCIENCE -- Life Sciences -- Human Anatomy & Physiology.
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Muscles -- Physiology
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Muscles -- Diseases
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Muscles
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| Form |
Electronic book
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| Author |
Sakuma, Kunihiro, editor of compilation
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| LC no. |
2020677651 |
| ISBN |
9781628083699 |
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1628083697 |
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