| Description |
1 online resource (xi, 361 pages) : illustrations |
| Contents |
Preface -- List of contributors -- 1. Statistical models and methods for incomplete data in randomized clinical trials / Michael A. McIsaac, Richard J. Cook -- 2. Bayesian Decision Theory and the design and analysis of randomized clinical trials / Andrew R. Willan -- 3. Designing multi-arm multi-stage clinical studies / Thomas Jaki -- 4. Statistical approaches to improving trial efficiency and conduct / Janice Pogue, P.J. Devereaux, SalimYusuf -- 5. Competing risks and survival analysis / Kees van Montfort, Peter Fennema, Wendimagegn Ghidey -- 6. Recent developments in group-sequential designs / James M.S. Wason -- 7. Statistical inference for non-inferiority of a diagnostic procedure compared to an alternative procedure, based on the difference in correlated proportions from multiple raters / Hiroyuki Saeki, Toshiro Tango -- 8. Design and analysis of clinical trial simulations / Kazuhiko Kuribayashi -- 9. Causal effect estimation and dose adjustment in exposure-response relationship analysis / Jixian Wang -- 10. Different methods to analyse results of a randomised controlled trial with more than one follow-up measurement / Jos W.R. Twisk -- 11. Statistical methods for the assessment of clinical relevance / Meinhard Kieser -- 12. Statistical considerations in the use of composite endpoints in time to event analyses / Richard J. Cook, Ker-Ai Lee -- 13. Statistical validation of surrogate markers in clinical trials / Ariel Alonso, Geert Molenberghs, Gerard van Breukelen -- 14. Biomarker-based designs of phase III clinical trials for personalized medicine / Shigeyuki Matsui, Takahiro Nonaka, Yuki Choai -- 15. Dose-finding models for two-agent combination phase I trials / Akihiro Hirakawa, Shigeyuki Matsui -- 16. Multi-state models used in oncology trials / Birgit Gaschler-Markefski [and others] -- 17. Review of designs for accommodating patients? or physicians? Preferences in randomized controlled trials / Afisi S. Ismaila, Stephen D. Walter -- 18. Dose finding methods in oncology: from the maximum tolerated dose to the recommended phase II dose / Xavier Paoletti, Adélaide Doussau |
| Summary |
This book describes various ways of approaching and interpreting the data produced by clinical trial studies, with a special emphasis on the essential role that biostatistics plays in clinical trials. Over the past few decades the role of statistics in the evaluation and interpretation of clinical data has become of paramount importance. As a result the standards of clinical study design, conduct and interpretation have undergone substantial improvement. The book includes 18 carefully reviewed chapters on recent developments in clinical trials and their statistical evaluation, with each chapter providing one or more examples involving typical data sets, enabling readers to apply the proposed procedures. The chapters employ a uniform style to enhance comparability between the approaches |
| Notes |
Online resource; title from PDF title page (EBSCO, viewed October 17, 2014) |
| Subject |
Clinical trials -- Statistical methods
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Clinical Trials as Topic -- statistics & numerical data
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HEALTH & FITNESS -- Holism.
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HEALTH & FITNESS -- Reference.
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MEDICAL -- Alternative Medicine.
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MEDICAL -- Atlases.
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MEDICAL -- Essays.
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MEDICAL -- Family & General Practice.
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MEDICAL -- Holistic Medicine.
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MEDICAL -- Osteopathy.
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Clinical trials -- Statistical methods
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| Form |
Electronic book
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| Author |
Montfort, Kees van, editor.
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Oud, Johan, editor.
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Ghidey, Wendimagegn, editor
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| ISBN |
9783642553455 |
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3642553451 |
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3642553443 |
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9783642553448 |
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9783642553462 |
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364255346X |
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9783662522110 |
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366252211X |
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