| Description |
1 online resource |
| Series |
Subcellular biochemistry, 0306-0225 ; v. 61 |
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Sub-cellular biochemistry ; v. 61.
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| Contents |
Part 1. EPIGENETICS AND EVOLUTION -- Chromatin Organization, Epigenetics and Differentiation: An Evolutionary Perspective / Sujata Kumari, Amrutha Swaminathan, Snehajyoti Chatterjee, Parijat Senapati and Ramachandran Boopathi, et al. -- Secondary Structures of the Core Histone N-terminal Tails: Their Role in Regulating Chromatin Structure / Louis L. du Preez and Hugh-G. Patterton -- Megabase Replication Domains Along the Human Genome: Relation to Chromatin Structure and Genome Organisation / Benjamin Audit, Lamia Zaghloul, Antoine Baker, Alain Arneodo and Chun-Long Chen, et al. -- Role of DNA Methyltransferases in Epigenetic Regulation in Bacteria / Ritesh Kumar and Desirazu N. Rao |
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Part 2. DEVELOPMENTAL EPIGENETICS -- Metabolic Aspects of Epigenome: Coupling of S-Adenosylmethionine Synthesis and Gene Regulation on Chromatin by SAMIT Module / Kazuhiko Igarashi and Yasutake Katoh -- Epigenetic Regulation of Male Germ Cell Differentiation / Oliver Meikar, Matteo Da Ros and Noora Kotaja -- Epigenetic Regulation of Skeletal Muscle Development and Differentiation / Narendra Bharathy, Belinda Mei Tze Ling and Reshma Taneja -- Small Changes, Big Effects: Chromatin Goes Aging / Asmitha Lazarus, Kushal Kr. Banerjee and Ullas Kolthur-Seetharam -- Homeotic Gene Regulation: A Paradigm for Epigenetic Mechanisms Underlying Organismal Development / Navneet K. Matharu, Vasanthi Dasari and Rakesh K. Mishra |
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Part 3. EPIGENETICS AND TRANSCRIPTION REGULATION -- Basic Mechanisms in RNA Polymerase I Transcription of the Ribosomal RNA Genes / Sarah J. Goodfellow and Joost C.B.M. Zomerdijk -- The RNA Polymerase II Transcriptional Machinery and Its Epigenetic Context / Maria J. Barrero and Sohail Malik -- RNA Polymerase III Transcription -- Regulated by Chromatin Structure and Regulator of Nuclear Chromatin Organization / Chiara Pascali and Martin Teichmann -- The Role of DNA Methylation and Histone Modifications in Transcriptional Regulation in Humans / Jaime L. Miller and Patrick A. Grant -- Histone Variants and Transcription Regulation / Cindy Law and Peter Cheung -- Noncoding RNAs in Chromatin Organization and Transcription Regulation: An Epigenetic View / Karthigeyan Dhanasekaran, Sujata Kumari and Chandrasekhar Kanduri -- Chromatin Structure and Organization: The Relation with Gene Expression During Development and Disease / Benoît Moindrot, Philippe Bouvet and Fabien Mongelard |
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Part 4. EPIGENETICS AND DISEASE -- Cancer: An Epigenetic Landscape / Karthigeyan Dhanasekaran, Mohammed Arif and Tapas K. Kundu -- Epigenetic Regulation of Cancer Stem Cell Gene Expression / Sharmila A. Bapat -- Role of Epigenetic Mechanisms in the Vascular Complications of Diabetes / Marpadga A. Reddy and Rama Natarajan -- Epigenetic Changes in Inflammatory and Autoimmune Diseases / Helene Myrtue Nielsen and Jörg Tost -- Epigenetic Regulation of HIV-1 Persistence and Evolving Strategies for Virus Eradication / Neeru Dhamija, Pratima Rawat and Debashis Mitra -- Epigenetics in Parkinson's and Alzheimer's Diseases / Sueli Marques and Tiago Fleming Outeiro -- Cellular Redox, Epigenetics and Diseases / Shyamal K. Goswami |
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Part 5. UNDERSTANDING OF EPIGENETICS: A CHEMICAL BIOLOGY APPROACH AND EPIGENETIC THERAPY -- Stem Cell Plasticity in Development and Cancer: Epigenetic Origin of Cancer Stem Cells / Mansi Shah and Cinzia Allegrucci -- Histone Acetylation as a Therapeutic Target / B. Ruthrotha Selvi, Snehajyoti Chatterjee, Rahul Modak, M. Eswaramoorthy and Tapas K. Kundu -- DNA Methylation and Cancer / Gopinathan Gokul and Sanjeev Khosla -- Role of Epigenetics in Inflammation-Associated Diseases / Muthu K. Shanmugam and Gautam Sethi -- Plasmodium falciparum: Epigenetic Control of var Gene Regulation and Disease |
| Summary |
Epigenetics is the phenomenon which fine tunes the processes associated with life, beyond that which is specified by the sequence of the genetic material; DNA. The covalent modification of DNA, DNA associated histones, several non histone proteins as well as non coding RNA coherently operate to establish the epigenetic regulation of gene expression in physiological and pathophysiological conditions. This volume presents contributions from worldwide experts presenting their research and findings, including: the evolution of epigenetic machineries from archaea to higher eukaryotes; role of epigenetics in development and transcription regulation; epigenetic landscape of human disease; a chemical biology approach to understanding epigenetic phenomena; exploration of different small molecules as epigenetic therapies. This volume is aimed at students and researchers of chromatin biology and epigenetics and will also be of interest to a broader pharmaceutical audience |
| Analysis |
Medicine |
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Oncology |
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Gene expression |
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Post-translational modification of proteins |
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Stem cells |
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Developmental biology |
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Biomedicine |
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Posttranslational Modification |
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Cancer Research |
| Notes |
Includes index |
| Bibliography |
Includes bibliographical references and index |
| In |
Springer eBooks |
| Subject |
Epigenetics.
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Genetic regulation.
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Epigenesis, Genetic
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Epigenomics
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Chromatin -- genetics
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Gene Expression Regulation
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SCIENCE -- Life Sciences -- Genetics & Genomics.
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Genetic regulation
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Epigenetics
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| Form |
Electronic book
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| Author |
Kundu, Tapas K.
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| ISBN |
9789400745254 |
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9400745257 |
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9400745249 |
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9789400745247 |
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