| Description |
1 online resource |
| Series |
Topics in Medicinal Chemistry Series ; v.41 |
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Topics in Medicinal Chemistry Series
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| Contents |
Intro -- Preface -- Contents -- Once Upon a Time Adenosine and Its Receptors: Historical Survey and Perspectives as Potential Targets for Therapy in Human Dis... -- 1 Introduction -- 2 Brief History of Adenosine and Its Receptors -- 3 The State of the Art -- 3.1 Adenosine Production and Metabolism -- 3.2 Distribution of Adenosine Receptors and Their Main Physiological Effects -- 3.3 Signal Transduction of Adenosine Receptors -- 3.4 Adenosine Receptor Structures -- 3.5 Medicinal Chemistry of Adenosine Receptor -- 3.5.1 Adenosine Receptor Ligands, in Short |
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3.5.2 Emerging Adenosine Receptor Ligands as Tool Compounds -- Agonists -- Antagonists -- 3.6 Pathophysiological Roles of Adenosine Receptors and Emerging Therapeutic Intervention -- 3.6.1 Central Nervous System Disorders -- 3.6.2 Pain -- 3.6.3 Inflammation and Immune Diseases -- 3.6.4 Cancer -- 3.6.5 Cardiovascular and Related Diseases -- 4 Perspectives -- 5 Concluding Remarks -- References -- Adenosine Receptor Ligands, Probes, and Functional Conjugates: A 20-Year History of Pyrazolo[4,3-e][1,2,4]Triazolo[1,5-c]Pyrim... -- 1 Introduction -- 1.1 A1 AR -- 1.2 A2A AR -- 1.3 A2B AR -- 1.4 A3 AR |
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2 Pyrazolo-Triazolo-Pyrimidines (PTP) as AR Antagonists -- 2.1 A2A AR Antagonists -- 2.2 A3 AR Antagonists -- 2.3 A2B and A1 ARs Antagonists -- 3 Probes and Functional Conjugates Targeting Adenosine Receptors Bearing a PTP Scaffold -- 3.1 Covalent Derivatives -- 3.2 Radiolabeled Derivatives -- 3.3 Conjugated Derivatives -- 3.3.1 Fluorescent Derivatives -- 3.3.2 Other Conjugates -- 4 Conclusions -- References -- Adenosine Receptor Ligands as Potential Therapeutic Agents for Impaired Wound Healing and Fibrosis -- 1 Introduction -- 2 The Wound Healing Process -- 3 Adenosine in Wound Healing |
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4 Adenosine and Fibrosis -- 5 Conclusions -- References -- Adenosine A2A Receptor Antagonists: Chemistry, SARs, and Therapeutic Potential -- 1 Introduction -- 2 A2A Adenosine Receptor Antagonists Evaluated in Clinical Trials -- 3 A2A Adenosine Receptor Antagonists -- 3.1 Xanthine Derivatives -- 3.2 Non-Xanthine Derivatives -- 3.2.1 Triazolo-Quinazoline and -Quinoxaline Derivatives -- 3.2.2 Pyrazolo-, Imidazolo-, and Thiazolo-Triazolopyrimidine Derivatives -- 3.2.3 Triazolo-Triazine, -Pyrimidine, and -Pyrazine Derivatives -- 3.2.4 Thiazolo- and Thieno-Pyrimidine Derivatives |
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3.2.5 Benzo-, Pyrimido-, and Oxazolo-Thiazolo Derivatives -- 3.2.6 Purine and Adenine Derivatives -- 3.2.7 Thiazole and Triazole Derivatives -- 3.2.8 Pyridine and Pyrimidine Derivatives -- 3.2.9 Pyrazine and Triazine Derivatives -- 4 Structural Features of A2A Structure and Its Interaction with Antagonists -- 5 Potential Application of A2A Adenosine Receptor Antagonists -- 5.1 A2A Adenosine Receptor Antagonists and Neurodegenerative Disorders -- 5.2 A2A Adenosine Receptor Antagonists and Neuroprotection -- 5.3 A2A Adenosine Receptor Antagonists and Cancer -- 6 Concluding Remarks -- References |
| Genre/Form |
Electronic books
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| Form |
Electronic book
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| ISBN |
9783031397257 |
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3031397258 |
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