| Description |
1 online resource (vi, 184 pages) : illustrations (some color) |
| Series |
Experientia Supplementum, 1023-294X ; volume 104 |
|
Experientia. Supplementum ; v. 104. 1023-294X
|
| Contents |
The Use of T Cells in Hazard Characterization of Chemical and Drug Allergens and Integration in Testing Strategies / Ian Kimber and Marc Pallardy -- Activation of the TCR Complex by Peptide-MHC and Superantigens / Christine Louis-Dit-Sully, Britta Blumenthal, Marlena Duchniewicz [and 6 others] -- Activation of the TCR Complex by Small Chemical Compounds / Christine Louis-Dit-Sully and Wolfgang W.A. Schamel -- T Cell Responses to Contact Allergens / Hans Ulrich Weltzien, Stefan F. Martin and Jean-François Nicolas -- Contact Hypersensitivity: Quantitative Aspects, Susceptibility and Risk Factors / Peter S. Friedmann and Christopher Pickard -- Tools and Methods for Identification and Analysis of Rare Antigen-Specific T Lymphocytes / Stefan F. Martin, Sonja S. Schmucker and Anne Richter -- Human T Cell Priming Assay: Depletion of Peripheral Blood Lymphocytes in CD25 + Cells Improves the In Vitro Detection of Weak Allergen-Specific T Cells / Marc Vocanson, Amine Achachi, Virginie Mutez, Magalie Cluzel-Tailhardat [and 4 others] -- Correlation of Contact Sensitizer Potency with T Cell Frequency and TCR Repertoire Diversity / Philipp R. Esser, Ian Kimber and Stefan F. Martin -- On the Role of Co-inhibitory Molecules in Dendritic Cell: T Helper Cell Coculture Assays Aimed to Detect Chemical-Induced Contact Allergy / Matthias Peiser, Manuel Hitzler and Andreas Luch -- T Cell Responses to Drugs and Drug Metabolites / C.J. Earnshaw, T. Pecaric-Petkovic, B.K. Park and D.J. Naisbitt -- Hypersensitivity Reactions to Beta-lactams / Maria J. Torres, Cristobalina Mayorga, Natalia Blanca-López and Miguel Blanca |
| Summary |
This book summarizes the state-of-the art in the development of T cell-based in vitro assays, which offer useful tools for hazard identification, risk assessment and improvement of diagnostics. It will be of interest to scientists, the chemical and pharmaceutical industry, and regulators involved in the replacement of animal testing methods. The identification of hazardous chemicals and drugs is essential to ensuring human health. The ban on animal testing for the cosmetics industry since 2009 and international efforts to reduce and replace animal testing in research and immunotoxicology call for alternative in vitro methods. The most specific immune response to chemicals and drugs that cause allergic contact dermatitis, respiratory disease and adverse drug reactions is the highly antigen-specific T lymphocyte response. Therefore the use of T cells as tools for identifying contact allergens and drugs that may cause health problems is of great interest |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Online resource; title from PDF title page (SpringerLink, viewed November 11, 2013) |
| Subject |
T cells.
|
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Molecular diagnosis.
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T-Lymphocytes -- immunology
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HEALTH & FITNESS -- Diseases -- General.
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MEDICAL -- Clinical Medicine.
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MEDICAL -- Diseases.
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MEDICAL -- Evidence-Based Medicine.
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MEDICAL -- Internal Medicine.
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Molecular diagnosis
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T cells
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| Form |
Electronic book
|
| Author |
Martin, Stefan F., editor
|
| ISBN |
9783034807265 |
|
3034807260 |
|
