Title Stereoselective syntheses of tetrahydropyrans : applications to the synthesis of (+)-Lecucascandrolide A, (+)-Dactylolide and (±)-Diospongon A / Kiyoun Lee

Published Cham : Springer, [2014]

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Description 1 online resource (xix, 184 pages) : illustrations (some color) Series Springer Theses, Recognizing Outstanding Ph. D. Research, Springer Theses, Recognizing Outstanding Ph. D. Research, Summary In his thesis, Kiyoun Lee describes his studies into tandem and organocatalytic oxa-conjugate addition reactions for the synthesis of complex tetrahydropyrans (THP). Readers gain insight into the new methods Lee employs for the synthesis of biologically interesting natural products including (+)-leucascandrolide A, (+)-dactylolide, and (±)-diospongin A. The reactions Lee investigates are applicable to a broad range of substrates and proceed with excellent stereoselectivity. Moreover, the methodologies allow the synthesis of a wide range of THP-containing compounds. The development of reactions, such as those discussed by Lee, has the potential to impact natural product synthesis, pharmaceutical development and chemical biology Bibliography Includes bibliographical references at the end of each chapters Notes English Subject Pharmaceutical technology. Chemistry, Organic. Chemical engineering. Chemistry. Chemistry Technology, Pharmaceutical Chemistry, Organic Chemical Engineering chemistry. organic chemistry. chemical engineering. SCIENCE -- Chemistry -- Organic. Chemical engineering Chemistry Chemistry, Organic Pharmaceutical technology Form Electronic book ISBN 9783319044620 3319044621

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