| Description |
1 online resource (258 p.) |
| Contents |
Front Cover -- SERS for Point-of-care and Clinical Applications -- SERS for Point-of-care and Clinical Applications -- Copyright -- Contents -- Contributors -- Editor biography -- 1 -- Data analysis in SERS diagnostics -- Introduction -- General data processing workflow -- Study definition and data collection -- Data handling considerations (data structures, organization) -- Metadata organization -- A bit of statistics -- Survey of software available -- Data integrity -- Outliers -- Data preprocessing -- Spectral preprocessing (row-wise methods) -- Normalization -- Model-based methods |
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Column transformations -- Models -- Exploratory data analysis (unsupervised learning) -- Regression -- Principal component regression -- Partial least squares regression -- Classification -- Linear discriminant analysis and quadratic discriminant analysis -- Logistic regression -- Principal component analysis and partial least squares as preprocessing: PCA-LDA, PLS-LDA, PLS-LR, etc. -- Soft independent modeling of class analogies -- Nonlinear models -- k nearest neighbors -- Support vector machines -- Artificial neural networks -- Verification of results -- Bias and variance in verification |
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Verification schemes -- Validation studies and assessing ruggedness -- Hold out/independent test sets -- Autoprediction (training error) -- Resampling: cross validation and out-of-bootstrap -- Figures of merit -- Regression -- Diagnostic plots -- Diagnostic plots -- Classification -- Sensitivity, specificity, predictive values, and similar proportions -- Sensitivity, specificity, predictive values, and similar proportions -- Model stability and overfitting -- Hyperparameter optimization -- Concluding remarks -- References -- 2 -- Label-free SERS techniques in biomedical applications |
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Introduction -- Oncological diseases -- Neurological diseases -- Infectious diseases -- Future challenges and perspectives -- References -- 3 -- SERS probes and tags for biomedical applications -- Introduction -- Surface-enhanced Raman scattering -- Design considerations -- Particle type -- Raman reporter -- Surface coating -- Targeting -- Sensing mechanism -- References -- 4 -- SERS biosensors for point-of-care infectious disease diagnostics -- Introduction -- Antibody-based SERS biosensors -- Aptamer-based SERS biosensors -- Nucleic acid-based SERS biosensors |
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SERS biosensors without bioreceptor -- Conclusion -- References -- 5 -- SERS-based molecular sentinel nanoprobes for nucleic acid biomarker detection -- Introduction -- Development of the iMS nanoprobe for label-free homogenous biosensing -- Silver-coated gold nanostars for SERS detection -- Detection scheme of the SERS iMS nanoprobe -- Development of iMS for detection of microRNA biomarkers -- Detection of miRNA biomarkers within biological samples -- RNA extracted from cancer cell lines -- Clinical evaluation of miRNA cancer biomarker detection using iMS nanoprobes |
| Notes |
Description based upon print version of record |
|
Multiplexed detection of miRNA biomarkers |
| Form |
Electronic book
|
| ISBN |
9780128209103 |
|
0128209100 |
|
