Title Self-perpetuating structural states in biology, disease, and genetics / edited by Susan Lindquist, Steve Henikoff

Published Washington, DC : National Academy of Sciences, [2002]

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Description 1 online resource : illustrations Series Sackler Colloquium series Arthur M. Sackler Colloquia of the National Academy of Sciences. Sackler Colloquium series. Summary Over the past half-century, the central dogma, in which DNA makes RNA makes protein, has dominated thinking in biology, with continuing refinements in understanding of DNA inheritance, gene expression, and macromolecular interactions. However, we have also witnessed the elucidation of epigenetic phenomena that violate conventional notions of inheritance. Protein-only inheritance involves the transmission of phenotypes by self-perpetuating changes in protein conformation. Proteins that constitute chromatin can also transmit heritable information, for example, via posttranslational modifications of histones. Both the transmission of phenotypes via the formation of protein conformations and the inheritance of chromatin states involve self-perpetuating assemblies of proteins, and there is evidence for some common structural features and conceptual frameworks between them. To foster interactions between researchers in these two fields, the National Academy of Sciences convened an Arthur M. Sackler Colloquium entitled "Self-Perpetuating Structural States in Biology, Disease, and Genetics" in Washington, DC, on March 22-24, 2002. Participants described new phenomenology and provided insights into fundamental mechanisms of protein and chromatin inheritance. Perhaps most surprising to attendees was emerging evidence that these unconventional modes of inheritance may be common Analysis Andre fag (naturvidenskab og teknik) Andre fag Notes Title from title screen Bibliography Includes bibliographical references Notes Version viewed January 12, 2015 Subject Cellular control mechanisms -- Congresses Biology -- Congresses DNA -- Congresses Prions -- Congresses Chromatin -- Congresses Proteins -- Conformation -- Congresses Proteins -- Conformation. Chromatin -- genetics Epigenesis, Genetic Histones -- genetics Protein Conformation SCIENCE -- Essays. SCIENCE -- Nanoscience. SCIENCE -- Reference. Biology Cellular control mechanisms Chromatin DNA Prions Proteins -- Conformation Genre/Form proceedings (reports) Conference papers and proceedings Conference papers and proceedings. Actes de congrès. Form Electronic book Author Lindquist, Susan, editor Henikoff, Steve, editor National Academy of Sciences (U.S.), sponsoring body. ISBN 0309084458 9780309084451 030957045X 9780309570459

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