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Title Heme peroxidases / edited by Emma Raven and Brian Dunford
Published Cambridge : Royal Society of Chemistry, [2016?]
©2016

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Description 1 online resource (xxii, 366 pages) : illustrations
Series RSC metallobiology ; 4
RSC metallobiology series ; 4
Contents Cover; Contents; Preface; References; Author Biographies; Section 1 Structure and Reactivity of Heme Peroxidases; Chapter 1 Self-processing of Peroxidases; 1.1 Introduction; 1.2 Protein Modifications; 1.2.1 Lignin Peroxidases; 1.2.2 KatG Peroxidases; 1.3 Heme-Protein Crosslinking; 1.3.1 Mammalian Peroxidase Ester Links; 1.3.2 Bacterial Peroxidase Ester Links; 1.3.3 MPO Methionine-Vinyl Crosslink; 1.3.4 Model Reactions; 1.3.5 Role of Methionine-Vinyl Crosslink; 1.3.6 Role of Ester Crosslinks; 1.4 Conclusions; References; Chapter 2 Cytochrome c Peroxidase-Cytochrome c Complexes
2.1 Initial Studies2.2 CCP-cytc Structure; 2.3 One Site or Two?; 2.4 Electron Transfer; 2.5 The CCP Trp Radical; 2.6 Other CCPs; 2.7 LmP-cytc Crystal Structure; 2.8 Summary and Conclusion; References; Chapter 3 Understanding the Reactivity and Interactions of Peroxidases with Substrates; 3.1 Introduction and Early Studies; 3.2 Development of a Framework for Substrate Binding across the Peroxidase Family; 3.3 Binding of Mn(ii) to Peroxidases; 3.4 Binding of Ascorbate to Peroxidases; 3.5 Binding of Hydroxamic Acids to Peroxidases; 3.6 Binding of Isoniazid to Peroxidases
3.7 Binding of Guaiacol and Other Phenolic Substrates to Peroxidases3.8 Summary; References; Chapter 4 Structural and Functional Properties of Heme-containing Peroxidases: a Resonance Raman Perspective for the Superfamily of Plant, Fungal and Bacterial Peroxidases; 4.1 Introduction; 4.2 Superfamily of Plant, Fungal and Bacterial Peroxidases; 4.3 An Overview of the Resonance Raman Spectroscopy of Heme Proteins; 4.3.1 Coordination and Spin States of Heme Proteins; 4.4 Distal Fe-Ligand Modes as a Probe of Heme Cavity Structure; 4.4.1 The Hydroxo Ligand; 4.4.2 The Fluoride Ligand
4.4.3 The CO Ligand4.5 The Proximal Iron-Histidine Stretching Mode: a Sensitive Probe of Proximal Properties; 4.5.1 Status of the Fe-proximal Histidine Bond in Peroxidases; 4.6 Effect of Mutation; 4.6.1 Proximal Mutation-induced Effects in the Distal Cavity; 4.6.2 Distal Mutation-induced Effects in the Proximal Cavity; 4.6.3 Control of Water Binding by Distal Mutation; 4.7 Raman Microscopy Combined with X-ray Crystallography; 4.8 Conclusions; Acknowledgments; References; Chapter 5 Heme Peroxidase Kinetics; 5.1 Introduction; 5.2 Kinetics: from the Steady State to Transient State
5.3 Oxidation States Six to Two5.4 Mechanism of Compound I Formation; 5.5 Neutron Diffraction Experiments on Yeast Cytochrome c Peroxidase; 5.6 Mechanism of Compound I Reduction; 5.6.1 Two-electron Reductions of Compound I; 5.7 Mechanism of Compound II Reduction; 5.8 Steady State Reactions; References; Chapter 6 Multiheme Peroxidases; 6.1 Biological Significance; 6.2 Structural Information; 6.2.1 Architecture of Bacterial Diheme Peroxidases; 6.2.2 Redox-dependent Structural Changes in bCCPs; 6.3 The Mechanism of Peroxide Reduction; 6.3.1 Reductive Activation of the Enzyme
Summary Heme peroxidases are widely distributed in biological systems and are involved in a wide range of processes essential for life. This book provides a comprehensive single source of information on the various aspects of heme peroxidase structure, function and mechanism of action. Chapters written and edited by worldwide experts span a range of heme peroxidases from plants, yeast, bacteria and mammals. Discussed functions of peroxidases range from cell wall synthesis, synthesis of prostaglandins, role in drug suppression of tuberculosis, and antibacterial activity. Included is a discussion of peroxidases that also act as catalases and oxygenases. Heme Peroxidases serves as an essential text for those working in industry and academia in biochemistry and metallobiology
Bibliography Includes bibliographical references and index
Notes Print version record
Subject Peroxidase.
Peroxidase
Form Electronic book
Author Raven, Emma L., editor.
Dunford, Brian, editor
Royal Society of Chemistry (Great Britain)
ISBN 9781782622628
1782622624
1849739110
9781849739115