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E-book

Title Ion channel drug discovery / edited by Brian Cox, Martin Gosling
Published Cambridge : Royal Society of Chemistry, 2015

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Description 1 online resource
Series RSC drug discovery ; no. 39
RSC drug discovery series ; 39.
Contents Ion channel drug discovery: a historical perspective / Brian Cox -- High-throughput screening / Alexander Böcker, Sabine Schaertl and Stephen D. Hess -- Automated electrophysiology in ion channel drug discovery / John Dunlop -- Structural understanding of ion channels in atomic detail / Phillip J. Stansfeld -- Voltage-gated sodium channels: structure, function, and molecular pharmacology / William A. Catterall -- AMPA receptor positive allosteric modulators: a case history / Simon E Ward -- The discovery of novel inhaled ENaC blockers for the treatment of cystic fibrosis lung disease / Catherine Howsham and Henry Danahay -- The therapeutic potential of small-molecule modulators of the cystic fibrosis transmembrane conductance regulator (CFTR) Cl-channel / Jia Liu, Gerta Cami-Kobeci, Yiting Wang, Pissared Khuituan, Zhiwei Cai, Hongyu Li, Stephen M. Husbands and David N. Sheppard -- TRPV1 antagonism: from research to clinic / Mark S. Nash, J. Martin Verkuyl and Gurdip Bhalay -- Open access to the KCNQ channel: retigabine and second generation M-current openers / Johannes Krupp, Anthony M. Rush, Britt-Marie Swahn and Martin Main -- The therapeutic potential of hERG1 K+ channels for treating cancer and cardiac arrhythmias / John Mitcheson and Annarosa Arcangeli -- Does nature do ion channel drug discovery better than us? / Richard J. Lewis, Irina Vetter, Fernanda C. Cardoso, Marco Inserra and Glenn King -- Antibodies as ion channel modulators / Wilson Edwards and Alan D. Wickenden -- Ion channel drug discovery: future perspectives / Martin Gosling
Notes Includes index
Bibliography Includes bibliographical references and index
Notes Print version record
Subject Pharmaceutical chemistry.
Drug development.
Ion channels.
Drug Discovery -- methods
Ion Channels
Chemistry, Pharmaceutical
Chemistry.
Biochemistry.
MEDICAL -- Pharmacology.
Drug development.
Ion channels.
Pharmaceutical chemistry.
Form Electronic book
Author Cox, Brian, contributing editor
Gosling, Martin, contributing editor
ISBN 9781849735087
1849735085
9781782623076
1782623078