Title New horizons in predictive toxicology : current status and application / Alan G.E. Wilson, editor

Published Cambridge, U.K. : Royal Society of Chemistry, 2011

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Description 1 online resource (xxix, 702 pages) : illustrations (some color) Series RSC Drug Discovery ; 12 RSC drug discovery series ; 12. Contents Acknowledgements -- Chapter 1. Introduction and overview / Alan G.E. Wilson -- Chapter 2. In silico tools for toxicity prediction / Mark T.D. Cronin -- Chapter 3. Development of an evaluation support system for estimating repeated-dose toxicity of chemicals based on chemical structure / Makoto Hayashi and Yuki Sakuratani -- Chapter 4. Towards a common regulatory framework for computational toxicology: current status and future perspectives / Andrew P. Worth and Aleksandra Mostrag-Szlichtyng -- Chapter 5. Information, informatics and modeling in predictive toxicology / Scott Boyer, Daniel Muthas and Nigel Greene -- Chapter 6. Cellular stress and in vitro predictive toxicology / Xuemei Liu, Jeffrey A. Kramer and Alan G.E. Wilson -- Chapter 7. In vitro genotoxicity / John J. Nicolette [and others] -- Chapter 8. Cardiac toxicity prediction: to simplify, or to integrate, that is the question / Vivek J. Kadambi, Colleen Synan and Katherine Brewer -- Chapter 9. In vitro approaches for determining liver-specific toxicity of new drug candidates / James M. McKim Jr. -- Chapter 10. Human-based in vitro experimental systems for the assessment of human-specific adverse drug effects: scientific concepts, current applications and promising approaches / Albert P. Li -- Chapter 11. Pathways of organ injury to define human response in organotypic cultures / Alison E.M. Vickers -- Chapter 12. Predicting drug-induced mitochondrial dysfunction / Sashi Nadanaciva and Yvonne Will -- Chapter 13. Non-clinical models for the evaluation of mechanisms of toxicity / Jeffrey A. Kramer -- Chapter 14. In vivo approaches to predictive toxicology using zebrafish / Michael T. Simonich, Jill A. Franzosa and Robert L. Tanguay -- Chapter 15. In vivo genetic toxicology: application to cancer risk assessment / Michael J. Schlosser and Christopher S. Farabaugh -- Chapter 16. Predicting hepatotoxicity in vivo / Timothy Maziasz -- Chapter 17. Immunotoxicity testing / Thomas T. Kawabata [and others] -- Chapter 18. In vitro developmental models and their applications in teratology research / Karen Augustine-Rauch, Julieta M. Panzica-Kelly and Cindy X. Zhang -- Chapter 19. Role and status of bridging biomarkers in predictive toxicology / William B. Mattes -- Chapter 20. Renal toxicity / K. Nasir M. Khan, Gordon C. Hard and Zaher A. Radi -- Chapter 21. Metabolism-based toxicology prediction / F. Peter Guengerich -- Chapter 22. Impact of drug transporters in the pharmacological and adverse reactions of drugs / Hiroyuki Kusuhara, Kazuya Maeda and Yuichi Sugiyama -- Chapter 23. Toxicokinetics / Dennis A. Smith -- Chapter 24. The role of computational systems biology models in toxicity testing in the 21st century: an example with predictive multi-scale models of the liver / Sudin Bhattacharya [and others] -- Chapter 25. Animal models of idiosyncratic, drug-induced liver injury / Christine M. Dugan, Patricia E. Ganey and Robert A. Roth -- Subject index Summary The sophistication of modelling and simulation technologies have improved dramatically over the past decade and their applications in toxicity prediction and risk assessment are of critical importance. The integration of predictive toxicology approaches will become increasingly necessary as industrial chemicals advance and as new pharmaceuticals enter the market. In this comprehensive discussion of predictive toxicology and its applications, leading experts express their views on the technologies currently available and the potential for future developments. The book covers a wide range of topics including in silico, in vitro and in vivo approaches that are being used in the safety assessment of chemical substances. It reflects the growing and urgent need to strengthen and improve our ability to predict the safety and risks posed by industrial and pharmaceutical chemicals in humans. The reader will find extensive information on the use of current animal models used for various toxicities and target mediated toxicities. Also discussed are the recent regulatory initiatives to improve the safety assessment of chemicals. The book provides an expert and comprehensive discussion on the current status and future directions of predictive toxicology and its application. The various chapters in the book also reflect the growing need for improvements in our technologies and abilities to predict toxicities of pharmaceutical and industrial chemicals to ensure product safety and protect public health Bibliography Includes bibliographical references and index Subject Toxicology -- Simulation methods Toxicology -- Animal models. Risk. Social sciences. Risk management. Pharmacology. Probabilities. Medical personnel. Public health. Life sciences. Organization. Statistics. Health services administration. Physical sciences. Medical care. Mathematical models. Risk assessment. Forecasting. Toxicology. Risk Social Sciences Risk Management Investigative Techniques Pharmacology Epidemiologic Measurements Analytical, Diagnostic and Therapeutic Techniques and Equipment Probability Health Occupations Public Health Biological Science Disciplines Organization and Administration Anthropology, Education, Sociology and Social Phenomena Disciplines and Occupations Statistics as Topic Health Services Administration Environment and Public Health Natural Science Disciplines Delivery of Health Care Epidemiologic Methods Health Care Evaluation Mechanisms Quality of Health Care Health Care Quality, Access, and Evaluation Models, Theoretical Risk Assessment Forecasting Toxicology Toxicology -- methods Forecasting -- methods Risk Assessment -- methods Health Workforce Health Personnel Patient Care Management -- methods Patient Care Management Patient Care social sciences. risk management. pharmacology. probability. public health. biological sciences. physical sciences. mathematical models. risk assessment. toxicology. statistics. Chemistry. MEDICAL -- Toxicology. Toxicology Statistics Social sciences Risk management Risk assessment Risk Public health Probabilities Physical sciences Pharmacology Organization Medical personnel Medical care Mathematical models Life sciences Health services administration Forecasting Toxicology -- Animal models Form Electronic book Author Wilson, A. G. E., 1947- Royal Society of Chemistry (Great Britain) ISBN 9781849733045 184973304X

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