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E-book

Title New frontiers in chemical biology : enabling drug discovery / [edited by] Mark Bunnage, David Thurston, David Fox
Published Cambridge : Royal Society of Chemistry, ©2010

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Description 1 online resource
Series RSC drug discovery ; 5
RSC drug discovery series ; 5.
Contents The chemical genetic approach : the interrogation of biological mechanisms with small molecule probes / Martin Fisher and Adam Nelson -- Applications for activity-based probes in drug discovery / L.E. Edgington and M. Bogyo -- Targeted intracellular protein degradation as a potential therapeutic strategy / A.R. Schneekloth and C.M. Crews -- Chemical biology of stem cell modulation / Stephen G. Davies and Angela J. Russell -- Chemical biology of histone modifications / Nathan R. Rose, Christopher J. Schofield and Tom D. Heightman -- Chemologics / Lyn H. Jones -- Antibody-drug conjugates in oncology / Philip R. Hamann and Russell G. Dushin -- Drug discovery by DNA-encoded libraries / Yizhou Li, Zheng Zhu and Xiaoyu Li
Summary Annotation Despite ever-increasing investment in biomedical research, there has been a significant decline in the number of new drug approvals in recent years. In an effort to improve productivity, the drug discovery community has increasingly looked to biotherapeutics such as antibodies, vaccines, nucleic acids, and peptides. Chemical biology is an emerging field at the interface between chemistry and biology. It utilises the tools and techniques of chemical synthesis to study and influence biological systems. Recent developments in this area have great potential in addressing the productivity challenges expressed above. For example, chemical biology studies have already led to the identification of novel targets with exciting therapeutic potential and it is clear that the field will prove a key enabler of target discovery in the future. Moreover, the precise synthetic manipulation of biological molecules involved in many chemical biology approaches is now fuelling a new wave of chemically-modified biologics, 'chemologics', with unique properties. In these, and many other ways, chemical biology is a key discipline within 21st century drug discovery and the purpose of this book is to highlight the most important developments. It provides a valuable resource for scientists in academia and industry who are looking to build their knowledge of this hot topic. The individual chapters cover crucial areas including chemical proteomics, chemical genetics, post-translational modifications, epigenetics, RNA interference, PROTACS, antibody-drug conjugates, and chemologics
Bibliography Includes bibliographical references and index
Notes English
Subject Drugs -- Design.
Pharmaceutical chemistry.
Pharmacology.
Chemistry.
Physical sciences.
Life sciences.
Structure-activity relationships (Biochemistry)
Laboratory Chemicals
Chemistry, Pharmaceutical
Genetic Phenomena
Investigative Techniques
Biochemical Phenomena
Pharmacological Phenomena
Phenomena and Processes
Analytical, Diagnostic and Therapeutic Techniques and Equipment
Specialty Uses of Chemicals
Pharmacology
Chemistry
Chemical Phenomena
Physiological Phenomena
Chemical Actions and Uses
Natural Science Disciplines
Biological Science Disciplines
Chemicals and Drugs
Disciplines and Occupations
Structure-Activity Relationship
Small Molecule Libraries
Drug Discovery
Genetic Structures
Drug Design
pharmacology.
chemistry.
physical sciences.
biological sciences.
MEDICAL -- Drug Guides.
MEDICAL -- Nursing -- Pharmacology.
MEDICAL -- Pharmacology.
MEDICAL -- Pharmacy.
Structure-activity relationships (Biochemistry)
Physical sciences
Pharmacology
Life sciences
Chemistry
Drugs -- Design
Pharmaceutical chemistry
Form Electronic book
Author Bunnage, Mark E.
Thurston, David E.
Fox, David
ISBN 9781849732178
1849732175