| Description |
1 online resource (493 pages) : illustrations (chiefly color) |
| Contents |
The chemistry of thiol oxidation and detection / Mauro Lo Conte, Kate S. Carroll -- Radical scavenging by thiols and the fate of thiyl radicals / Christine C. Winterbourn -- Redox homeostasis / Joris Messens, Nicolas Rouhier, Jean-François Collet -- Sulfenic acids and peroxiredoxins in oxidant defense and signaling / Leslie B. Poole, Kimberly J. Nelson, P. Andrew Karplus -- Fluorescent imaging of redox species in multicellular organisms / Yuuta Fujikawa, Bruce Morgan, Tobias P. Dick -- Redox proteomics / Alexandra Müller, Lars I. Leichert -- Computational redox biology: methods and applications / Stefano M. Marino, Goedele Roos, Vadim N. Gladyshev -- Redox regulation in plants: glutathione and "redoxin" related families / J.P. Jacquot, K.J. Dietz, N. Rouhier, E. Meux, P.A. Lallement, B. Selles, A. Hecker -- Prokaryotic redox switches / John D. Helmann -- Combating oxidative/nitrosative stress with electrophilic counterattack strategies / Takumi Satoh, Mohd Waseem Akhtar, Stuart A. Lipton -- Reactive oxygen species, kinase signaling, and redox regulation of epigenetics / Isaac K. Sundar, Irfan Rahman -- Redox regulation of stem cell function / Heinrich Jasper, Dirk Bohmann -- Oxidative stress in infectious diseases / Esther Jortzik, Katja Becker -- Role of oxidative stress in aging / D. Knoefler, H.L. Tienson, U. Jakob -- Oxidative stress in cancer / Peter Storz -- Redox pathways as a platform in drug development / Danyelle M. Townsend, Kenneth D. Tew |
| Summary |
Many physiological conditions such as host defense or aging and pathological conditions such as neurodegenerative diseases, and diabetes are associated with the accumulation of high levels of reactive oxygen species and reactive nitrogen species. This generates a condition called oxidative stress. Low levels of reactive oxygen species, however, which are continuously produced during aerobic metabolism, function as important signaling molecules, setting the metabolic pace of cells and regulating processes ranging from gene expression to apoptosis. For this book we would like to recruit the experts in the field of redox chemistry, bioinformatics and proteomics, redox signaling and oxidative stress biology to discuss how organisms achieve the appropriate redox balance, the mechanisms that lead to oxidative stress conditions and the physiological consequences that contribute to aging and disease |
| Analysis |
Life sciences |
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Cytology |
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Oxidative Stress |
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Medical Biochemistry |
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Cell Physiology |
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Posttranslational Modification |
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Systems Biology |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Online resource; title from electronic title page (SpringerLink, viewed on February 19, 2015) |
| Subject |
Oxidative stress.
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Post-translational modification.
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Oxidation-reduction reaction.
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Active oxygen.
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Oxidative Stress -- physiology
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Oxidation-Reduction
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Oxidative Stress
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Protein Processing, Post-Translational
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Reactive Oxygen Species
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SCIENCE -- Life Sciences -- Anatomy & Physiology.
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Oxidation-reduction reaction
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Active oxygen
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Oxidative stress
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Post-translational modification
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| Form |
Electronic book
|
| Author |
Jakob, Ursula, editor
|
|
Reichmann, Dana, editor
|
| ISBN |
9789400757875 |
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9400757875 |
|
