| Description |
1 online resource (xii, 439 pages) : illustrations (some color) |
| Series |
Cancer drug discovery and development, 2196-9906 |
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Cancer drug discovery and development.
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| Contents |
Part I. Gene Regulation and Cancer. Steroid Receptor Coactivators (SRCs) as Integrators of Multiple Signaling Pathways in Cancer Progression / Weiwen Long and Bert W. O'Malley -- Role of Alteration/Deficiency in Activation (ADA) Complex in Cell Cycle, Genomic Instability and Cancer / Shakur Mohibi, Shashank Srivastava, Hamid Band and Vimla Band -- RUNX2 Transcriptional Regulation in Development and Disease / Jessica L. Brusgard Student and Antonino Passaniti -- Epigenetic Mechanisms of Cancer Metastasis / Jing Liang, Yongfeng Shang -- Part II. Signaling Pathway and Cancer. Regulatory Effects of Arsenic on Cellular Signaling Pathways: Biological Effects and Therapeutic Implications / Elspeth M. Beauchamp, Ruth Serrano and Leonidas C. Platanias. -- Nuclear Factors Linking Cancer and Inflammation / Kunzang Chosdol, Mohita Bhagat, Bhawana Dikshit, Evanka Madan, Parthaprasad Chattopadhyay and Subrata Sinha -- Regulation of the Jak/STATs Pathways by Histone Deacetylases / David M. Woods, Maritza Lienlaf-Moreno Eduardo Sotomayor, Edward Seto and Alejandro Villagra -- Receptor Tyrosine Kinases in the Nucleus: Nuclear Functions and Therapeutic Implications in Cancers / Longfei Huo, Jennifer L. Hsu and Mien-Chie Hung -- Nucleolar Signaling Determines Cell Fate: The RP-Mdm2-p53 Axis Fine-Tunes Cellular Homeostasis / Yong Liu and Yanping Zhang -- Transcriptional Regulation of Lipogenesis as a Therapeutic Target for Cancer Treatment / Chenguang Wang, Jun-Yuan Ji, Lifeng Tian and Richard G. Pestell -- Part III. Protein Domains and Cancer Therapeutics. Selective Inhibition of Acetyl-Lysine Effector Domains of the Bromodomain Family in Oncology / Susanne Müller, Hannah Lingard and Stefan Knapp -- Domain Specific Targeting of Cancer / Pratik Chandrani and Amit Dutt -- Part IV. Targeted Cancer Therapy. The Potential of Targeting Splicing for Cancer Therapy / Ana Rita Grosso and Maria Carmo-Fonseca. -- Exploiting Cell Cycle Pathways in Cancer Therapy: New (and Old) Targets and Potential Strategies / Angela Alexander and Khandan Keyomarsi -- Histone Demethylases in Prostate Cancer / Ling-Yu Wang, Wenchang Guo, Kevin Kim, Mamata Pochampalli, Chiu-Lien Hung, Yoshiro Izumiya and Hsing-Jien Kung -- Therapeutic Significance of Chromatin Remodeling Complexes in Cancer / Da-Qiang Li and Rakesh Kumar |
| Summary |
At the moment, there is no dedicated book to summarize the roles, the significance, and potential therapeutic targeting of transcriptional factors from the perspective of signaling cascade, and thus, directly impacting the functionality of transcriptional factors in cancer. In addition, this book will offer a comprehensive basic and clinical science behind the functions of representative core transcriptional factors. These chapters will serve as a treasure for all those who have an interest in the basis, progression, and targeting of human cancer |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Print version record |
| Subject |
Transcription factors.
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Cancer -- Genetic aspects.
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Cancer -- Treatment.
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Neoplasms -- genetics
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Neoplasms -- therapy
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Signal Transduction -- physiology
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Transcription Factors
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HEALTH & FITNESS -- Diseases -- General.
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MEDICAL -- Clinical Medicine.
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MEDICAL -- Diseases.
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MEDICAL -- Evidence-Based Medicine.
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MEDICAL -- Internal Medicine.
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Cancer -- Genetic aspects
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Cancer -- Treatment
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Transcription factors
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| Form |
Electronic book
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| Author |
Kumar, Rakesh (Professor of Biotechnology)
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| ISBN |
9781461480396 |
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1461480396 |
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1461480388 |
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9781461480389 |
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