Title Chembiomolecular science : at the frontier of chemistry and biology / Masakatsu Shibasaki, Masamitsu Iino, Hiroyuki Osada, editors

Published Tokyo : Springer, [2013] ©2013

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Description 1 online resource (341 pages) : illustrations (some color) Contents Part 1. Chembiomolecular chemistry -- Chemistry of mycolactones, the causative toxins of Buruli ulcer / Yoshito Kishi -- Practical synthesis of Tamiflu and beyond / Motomu Kanai -- An approach toward identification of target proteins of maitotoxin based on organic synthesis / Tohru Oishi, Keiichi Konoki, Rie Tamate, Kohei Torikai and Futoshi Hasegawa, et al. -- Inhibitors of fatty acid amide hydrolase / Dale L. Boger -- Small molecule tools for cell biology and cell therapy / Motonari Uesugi -- Toward the discovery of small molecules affecting rna function / Shiori Umemoto, Changfeng Hong, Jinhua Zhang, Takeo Fukuzumi and Asako Murata, et al. -- New insights from a focused library approach aiming at development of inhibitors of dual-specificity protein phosphatases / Go Hirai, Ayako Tsuchiya and Mikiko Sodeoka -- The deep oceans as a source for new treatments for cancer / William Fenical, James J. La Clair, Chambers C. Hughes, Paul R. Jensen and Susana P. Gaudêncio, et al. -- Search for new medicinal seeds from marine organisms / Motomasa Kobayashi, Naoyuki Kotoku and Masayoshi Arai -- Identification of protein-small molecule interactions by chemical array / Hiroyuki Osada and Siro Simizu Part 2. Chembiomolecular biology -- Small molecule-induced proximity / Fu-Sen Liang and Gerald R. Crabtree -- High-throughput screening for small molecule modulators of FGFR2-IIIb rre-mRNA Splicing / Erik S. Anderson, Peter Stoilov, Robert Damoiseaux and Douglas L. Black -- Identification of signaling pathways that mediate dietary restriction-induced longevity in Caenorhabditis elegans / Masaharu Uno, Sakiko Honjoh and Eisuke Nishida -- Roles for the stress-responsive kinases ASK1 and ASK2 in Tumorigenesis / Miki Kamiyama, Takehiro Sato, Kohsuke Takeda and Hidenori Ichijo -- Tailored synthetic surfaces to control human pluripotent stem cell self-renewal / Laura L. Kiessling -- Cell-surface glycoconjugates controlling human T-Lymphocyte homing: implications for bronchial asthma and atopic dermatitis / Reiji Kannagi, Keiichiro Sakuma and Katsuyuki Ohmori -- Establishment of a novel system for studying the Syk function in B cells / Tomohiro Kurosaki and Clifford A. Lowell -- Visual screening for the natural compounds that affect the formation of nuclear structures / Kaya Shigaki, Kazuaki Tokunaga, Yuki Mihara, Yota Matsuo and Yamato Kojimoto, et al. -- Versatile orphan nuclear receptor NR4A2 As a promising molecular target for multiple sclerosis and other autoimmune diseases / Shinji Oki, Benjamin J.E. Raveney, Yoshimitsu Doi and Takashi Yamamura -- Antiviral microRNA / Ryota Ouda and Takashi Fujita -- Synaptic function monitored using chemobiomolecular indicators / Masamitsu Iino Part 3. Chembiomolecular medicinal chemistry -- Practical catalytic asymmetric synthesis of a promising drug candidate / Masakatsu Shibasaki -- Hunting the targets of natural product-inspired compounds / Slava Ziegler and Herbert Waldmann -- Chemical approaches for understanding and controlling infectious diseases / Hirokazu Arimoto -- Nongenomic mechanism-mediated renal fibrosis-decreasing activity of a series of PPAR-[gamma] agonists / Hiroyuki Miyachi -- Novel carbohydrate-based inhibitors that target influenza a virus sialidase / Mark von Itzstein -- Multidrug efflux pumps and development of therapeutic strategies to control infectious diseases / Kunihiko Nishino -- Enzymes as chemotherapeutic agents / Ronald T. Raines -- Mechanism of action of new antiinfectious agents from microorganisms / Nobuhiro Koyama and Hiroshi Tomoda -- Correction of RNA splicing with antisense oligonucleotides as a therapeutic strategy for a neurodegenerative disease / Yimin Hua, Kentaro Sahashi, Frank Rigo, Gene Hung and C. Frank Bennett, et al. -- Modulation of pre-mRNA splicing patterns with synthetic chemicals and their clinical applications / Masatoshi Hagiwara Summary At the forefront of life sciences today is the emerging discipline of chembiomolecular science. This new term describes the integration of the frontier fields of chemical biology, chemistry, and pharmacology. Chembiomolecular science aims to elucidate new biological mechanisms as potential drug targets and enhance the creation of new drug therapies. This book comprises the proceedings of the Uehara Memorial Foundation Symposium 2011, which focused on the most recent advances in chembiomolecular science made by leading experts in the field. The book is divided into three main topics. The first is the chemical approach to understanding complex biological systems on a molecular level using chemical compounds as a probe. The second describes the biological approach used to develop new lead drug compounds. The third focuses on the biological system that serves as the potential drug target, the beginning step in the process of developing new drugs. Replete with the latest research, the book will draw the attention of all scientists interested in the synergies between chemistry and biology to elucidate life on a molecular level and to promote drug discovery. Ultimately, the book helps promote the understanding of biological functions at the molecular level and create new pharmaceuticals that can contribute to improving human health Analysis Life sciences Medicine Biochemistry Cytology Cell Biology Molecular Medicine Bibliography Includes bibliographical references and index Notes Online resource; title from digital title page (SpringerLink, viewed on November 11, 2014) Subject Biochemistry -- Congresses Pharmaceutical chemistry -- Congresses Biochemistry. Pharmaceutical chemistry. Biochemistry Chemistry, Pharmaceutical biochemistry. SCIENCE -- Life Sciences -- Biochemistry. Biochemistry Pharmaceutical chemistry Genre/Form proceedings (reports) Conference papers and proceedings Conference papers and proceedings. Actes de congrès. Form Electronic book Author Shibasaki, Masakatsu, editor. Iino, Masamitsu, editor Osada, H. (Hiroyuki), 1954- editor. LC no. 2012948879 ISBN 9784431540380 4431540385

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