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Title Epigenetic regulation of lymphocyte development / Cornelis Murre, editor
Published Berlin ; New York : Springer, ©2012

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Description 1 online resource (x, 191 pages)
Series Current topics in microbiology and immunology, 0070-217X ; v. 356
Current topics in microbiology and immunology ; v. 356.
Contents Introduction -- Transcription Factors Co-Localize in a Cell Type-Specific Manner -- Transcription Factors Collaborate to Gain Access to Chromatinized DNA on a Genome-Wide Scale -- Ternary Complex Formation Plays a Minor Role in Defining Genome-Wide Transcription Factor Binding Patterns -- A Case for Chromatin -- Pioneer Factors Collaborate to Access the Chromatinized Genome -- Genome-Wide Data Supports a Collaborative Mechanism of Transcription Factor Binding Patterning -- Transcription Factor Concentrations Define the Joint Binding Pattern -- Lineage-Determining Transcription Factors Prime Lineage-Specific Cis-Regulatory Modules -- A Two-Tiered System of Transcription Factors? -- Lineage-Determining Factors Induce Histone H3K4 Mono-and Di-Methylation Surrounding Their Binding Sites -- Mechanistic Notes -- Signal-Dependent Transcription Factors Act on Primed CREs -- Implications for Cellular Development and Reprogramming -- Putting it All Together -- Epigenomics as a Means to Identify the Factors Necessary for Cellular Reprogramming? -- Outlook -- References -- B Lymphocyte Lineage Specification, Commitment and Epigenetic Control of Transcription by Early B Cell Factor 1 -- Abstract -- Prologue -- Introduction -- Early B Cell Factor 1: Protein Structure and Function -- Early Studies of EBF1 -- X-ray Crystallographic Analysis of EBF1 Structure -- Structures of Other Domains in EBF1 -- Control of B Lymphopoiesis Requires a Network of Proteins Including EBF1 -- EBF1 and the Basis of B Lineage Fate Decisions -- Effects of Changes in Ebf1 Gene Dosage on B Cell Development -- EBF1 and B Cell Lineage Commitment -- Identification of EBF1 Target Genes Using Genome-Wide Analysis -- Binding of EBF1 to a Vast Array of Sites in Pro-B Cells -- Co-occupancy of Genes by EBF1 and E2A -- Epigenetic Regulation of Genes by EBF1 -- Multiple Mechanisms Activate Cd79a Transcription in Early B Cells -- Conclusions -- Acknowledgments -- References -- Epigenetic Features that Regulate IgH Locus Recombination and Expression -- Abstract -- Overview of the Immunoglobulin Heavy Chain Genomic Organization -- The First Step of IgH Gene Assembly: DH to JH Recombination -- Features of DH to JH Recombination -- Regulation of DH Recombination -- Epigenetic Features of the DH -- C mu Domain -- Chromosome Conformation of the DH -- C mu Domain -- Functional Implications of the Structure of the 3vprime IgH Domain -- The Second Step of IgH Gene Assembly: VH to DJH Recombination -- Chromatin Structural Changes that Accompany DH to JH Recombination -- How does DJH Recombination Activate VH Recombination? -- Regulation of VH Gene Recombination -- Differential Regulation of Proximal and Distal VH Recombination -- Epigenetic Features that Could Mediate Differential VH Gene Recombination -- Spatial Configuration of Distal and Proximal VH Genes -- Distinct Histone Modifications may Regulate Proximal and Distal VH Recombination -- Coordinating Locus Compaction and Histone Modification of VH Genes -- Conclusions -- Acknowledgments -- References -- Local and Global Epigenetic Regulation of V(D)J Recombination -- Abstract -- Introduction -- Epigenetic Mechanisms at the Level of the Igh Locus -- Histone Modifications -- Non-Coding RNA Transcription -- Intergenic Transcription -- Antisense and Intergenic Transcription in the Igh Locus V Region
Antisense and Intergenic Transcription in the Igh D Region -- In vivo Function for Intergenic Transcription in V(D)J Recombination -- Rag Binding -- Do ncRNA Transcripts Play a Role in V(D)J Recombination? -- Regulatory Elements Governing the Igh Locus -- Nuclear Organization of V(D)J Recombination -- The Role of Transcription in Nuclear Organization of V(D)J Recombination -- Concluding Summary -- Acknowledgments -- References -- Genetic and Epigenetic Regulation of Tcrb Gene Assembly -- Abstract -- Introduction -- Tcr Gene Assembly During Thymocyte Development -- Genetic Determinants of Recombination Efficiency -- RSSs and Ordered Tcrb Assembly -- Transcriptional Promoters and Enhancers -- Epigenetic Determinants: Regulating RSS Chromatin Accessibility -- The Epigenetic Landscape -- Promoter-mediated D beta J beta Recombination -- Promoter-Mediated Accessibility of V beta -to-D beta J beta Recombination -- Regulating Locus Assembly Beyond 12/23 -- Long-range Changes in Locus Conformation -- Tcrb Allelic Exclusion -- Conclusions -- Acknowledgments -- References -- T-Cell Identity and Epigenetic Memory -- Abstract -- The Problem of T-Cell Identity -- Combinatoriality -- Epigenetics and Hit-and-Run Gene Regulation -- Interplay Between Cellular History and Current Activation State: Examples from Cytokine Gene Control -- Reversibility and Plasticity of Histone Marks -- Combinatorial Transcription Factor Action and Epigenetic Modification -- A Problem of Repression -- Epigenetic Marking Events in T-Lineage Gene Activation from Stem-Cell Precursors -- Epigenetic Repression of Non-T-Cell Genes During T-Lineage Commitment -- Concluding Remarks: Open Prospects -- Acknowledgments -- References -- Encoding Stability Versus Flexibility: Lessons Learned From Examining Epigenetics in T Helper Cell Differentiation -- Abstract -- T Helper Cell Lineages -- Lineage-Defining Transcription Factors in Helper T Cell Development -- Chromatin and Gene Expression -- Chromatin Structure at Key Cytokine and Lineage-Defining Factor Loci -- Simultaneous Expression of Lineage-Defining Factors: Friend or Foe? -- The Role for T-bet in Th1 Cells -- T-bet Regulates Prototypic Th1 Genes -- T-bet Interacts with Chromatin-Modifying Complexes -- Chromatin-Dependent Mechanisms for Other T Helper Cell Lineage-Defining Factors -- Chromatin-Independent Activities for T-bet -- Mechanisms for Antagonism Between Lineage-Defining Factors -- Functional Cooperation Between Lineage-Defining Factors -- Predicting the Functional Significance for the Co-Expression of Lineage-Defining Transcription Factors in T Helper Cells -- Acknowledgments -- References -- The Epigenetic Landscape of Lineage Choice: Lessons From the Heritability of Cd4 and Cd8 Expression -- Abstract -- Introduction -- The T cell Helper versus Cytotoxic Lineage Choice as a Model for Bi-potential Fate Decisions -- Molecular Mechanism of Transcriptional Regulation and Epigenetic Propagation -- Epigenetic Regulation of Co-Receptor Loci -- Epigenetic Regulation of the Cd4 Locus -- Epigenetic Regulation of the Cd8 Locus -- Long Distance Interactions between Cd4 and Cd8 Co-Receptor Loci During Lineage Choice -- Concluding Remarks
Summary Previous observations, generated by many in the field, have provided a first glimpse into the epigenetic mechanisms that underpin lymphocyte and myeloid development. We are only now beginning to merge the multitude of observations into a common framework. At the same time it has become more difficult for the individual mind to comprehend more than a tiny focused fraction of it. The studies described in this volume serve as a starting point to familiarize one self with the multifarious differences in epigenetic designs that orchestrate the progression of developing blood cells. They also may serve as a general paradigm for the mechanisms that underpin the control of eukaryotic gene expression
Analysis Medicine
Gene expression
Immunology
Biomedicine
biomedische wetenschappen
immunologie
genexpressie
Medicine (General)
Geneeskunde (algemeen)
Bibliography Includes bibliographical references and index
Notes English
Subject Lymphocytes.
Epigenetics.
Genetic regulation.
Lymphocytes
Epigenesis, Genetic
Gene Expression Regulation
MEDICAL -- Physiology.
SCIENCE -- Life Sciences -- Human Anatomy & Physiology.
Epigenetics
Genetic regulation
Lymphocytes
Form Electronic book
Author Murre, Cornelis.
ISBN 9783642241031
3642241034
3642241026
9783642241024
3642447678
9783642447679