Description |
1 online resource (x, 191 pages) |
Series |
Current topics in microbiology and immunology, 0070-217X ; v. 356 |
|
Current topics in microbiology and immunology ; v. 356.
|
Contents |
Introduction -- Transcription Factors Co-Localize in a Cell Type-Specific Manner -- Transcription Factors Collaborate to Gain Access to Chromatinized DNA on a Genome-Wide Scale -- Ternary Complex Formation Plays a Minor Role in Defining Genome-Wide Transcription Factor Binding Patterns -- A Case for Chromatin -- Pioneer Factors Collaborate to Access the Chromatinized Genome -- Genome-Wide Data Supports a Collaborative Mechanism of Transcription Factor Binding Patterning -- Transcription Factor Concentrations Define the Joint Binding Pattern -- Lineage-Determining Transcription Factors Prime Lineage-Specific Cis-Regulatory Modules -- A Two-Tiered System of Transcription Factors? -- Lineage-Determining Factors Induce Histone H3K4 Mono-and Di-Methylation Surrounding Their Binding Sites -- Mechanistic Notes -- Signal-Dependent Transcription Factors Act on Primed CREs -- Implications for Cellular Development and Reprogramming -- Putting it All Together -- Epigenomics as a Means to Identify the Factors Necessary for Cellular Reprogramming? -- Outlook -- References -- B Lymphocyte Lineage Specification, Commitment and Epigenetic Control of Transcription by Early B Cell Factor 1 -- Abstract -- Prologue -- Introduction -- Early B Cell Factor 1: Protein Structure and Function -- Early Studies of EBF1 -- X-ray Crystallographic Analysis of EBF1 Structure -- Structures of Other Domains in EBF1 -- Control of B Lymphopoiesis Requires a Network of Proteins Including EBF1 -- EBF1 and the Basis of B Lineage Fate Decisions -- Effects of Changes in Ebf1 Gene Dosage on B Cell Development -- EBF1 and B Cell Lineage Commitment -- Identification of EBF1 Target Genes Using Genome-Wide Analysis -- Binding of EBF1 to a Vast Array of Sites in Pro-B Cells -- Co-occupancy of Genes by EBF1 and E2A -- Epigenetic Regulation of Genes by EBF1 -- Multiple Mechanisms Activate Cd79a Transcription in Early B Cells -- Conclusions -- Acknowledgments -- References -- Epigenetic Features that Regulate IgH Locus Recombination and Expression -- Abstract -- Overview of the Immunoglobulin Heavy Chain Genomic Organization -- The First Step of IgH Gene Assembly: DH to JH Recombination -- Features of DH to JH Recombination -- Regulation of DH Recombination -- Epigenetic Features of the DH -- C mu Domain -- Chromosome Conformation of the DH -- C mu Domain -- Functional Implications of the Structure of the 3vprime IgH Domain -- The Second Step of IgH Gene Assembly: VH to DJH Recombination -- Chromatin Structural Changes that Accompany DH to JH Recombination -- How does DJH Recombination Activate VH Recombination? -- Regulation of VH Gene Recombination -- Differential Regulation of Proximal and Distal VH Recombination -- Epigenetic Features that Could Mediate Differential VH Gene Recombination -- Spatial Configuration of Distal and Proximal VH Genes -- Distinct Histone Modifications may Regulate Proximal and Distal VH Recombination -- Coordinating Locus Compaction and Histone Modification of VH Genes -- Conclusions -- Acknowledgments -- References -- Local and Global Epigenetic Regulation of V(D)J Recombination -- Abstract -- Introduction -- Epigenetic Mechanisms at the Level of the Igh Locus -- Histone Modifications -- Non-Coding RNA Transcription -- Intergenic Transcription -- Antisense and Intergenic Transcription in the Igh Locus V Region |
|
Antisense and Intergenic Transcription in the Igh D Region -- In vivo Function for Intergenic Transcription in V(D)J Recombination -- Rag Binding -- Do ncRNA Transcripts Play a Role in V(D)J Recombination? -- Regulatory Elements Governing the Igh Locus -- Nuclear Organization of V(D)J Recombination -- The Role of Transcription in Nuclear Organization of V(D)J Recombination -- Concluding Summary -- Acknowledgments -- References -- Genetic and Epigenetic Regulation of Tcrb Gene Assembly -- Abstract -- Introduction -- Tcr Gene Assembly During Thymocyte Development -- Genetic Determinants of Recombination Efficiency -- RSSs and Ordered Tcrb Assembly -- Transcriptional Promoters and Enhancers -- Epigenetic Determinants: Regulating RSS Chromatin Accessibility -- The Epigenetic Landscape -- Promoter-mediated D beta J beta Recombination -- Promoter-Mediated Accessibility of V beta -to-D beta J beta Recombination -- Regulating Locus Assembly Beyond 12/23 -- Long-range Changes in Locus Conformation -- Tcrb Allelic Exclusion -- Conclusions -- Acknowledgments -- References -- T-Cell Identity and Epigenetic Memory -- Abstract -- The Problem of T-Cell Identity -- Combinatoriality -- Epigenetics and Hit-and-Run Gene Regulation -- Interplay Between Cellular History and Current Activation State: Examples from Cytokine Gene Control -- Reversibility and Plasticity of Histone Marks -- Combinatorial Transcription Factor Action and Epigenetic Modification -- A Problem of Repression -- Epigenetic Marking Events in T-Lineage Gene Activation from Stem-Cell Precursors -- Epigenetic Repression of Non-T-Cell Genes During T-Lineage Commitment -- Concluding Remarks: Open Prospects -- Acknowledgments -- References -- Encoding Stability Versus Flexibility: Lessons Learned From Examining Epigenetics in T Helper Cell Differentiation -- Abstract -- T Helper Cell Lineages -- Lineage-Defining Transcription Factors in Helper T Cell Development -- Chromatin and Gene Expression -- Chromatin Structure at Key Cytokine and Lineage-Defining Factor Loci -- Simultaneous Expression of Lineage-Defining Factors: Friend or Foe? -- The Role for T-bet in Th1 Cells -- T-bet Regulates Prototypic Th1 Genes -- T-bet Interacts with Chromatin-Modifying Complexes -- Chromatin-Dependent Mechanisms for Other T Helper Cell Lineage-Defining Factors -- Chromatin-Independent Activities for T-bet -- Mechanisms for Antagonism Between Lineage-Defining Factors -- Functional Cooperation Between Lineage-Defining Factors -- Predicting the Functional Significance for the Co-Expression of Lineage-Defining Transcription Factors in T Helper Cells -- Acknowledgments -- References -- The Epigenetic Landscape of Lineage Choice: Lessons From the Heritability of Cd4 and Cd8 Expression -- Abstract -- Introduction -- The T cell Helper versus Cytotoxic Lineage Choice as a Model for Bi-potential Fate Decisions -- Molecular Mechanism of Transcriptional Regulation and Epigenetic Propagation -- Epigenetic Regulation of Co-Receptor Loci -- Epigenetic Regulation of the Cd4 Locus -- Epigenetic Regulation of the Cd8 Locus -- Long Distance Interactions between Cd4 and Cd8 Co-Receptor Loci During Lineage Choice -- Concluding Remarks |
Summary |
Previous observations, generated by many in the field, have provided a first glimpse into the epigenetic mechanisms that underpin lymphocyte and myeloid development. We are only now beginning to merge the multitude of observations into a common framework. At the same time it has become more difficult for the individual mind to comprehend more than a tiny focused fraction of it. The studies described in this volume serve as a starting point to familiarize one self with the multifarious differences in epigenetic designs that orchestrate the progression of developing blood cells. They also may serve as a general paradigm for the mechanisms that underpin the control of eukaryotic gene expression |
Analysis |
Medicine |
|
Gene expression |
|
Immunology |
|
Biomedicine |
|
biomedische wetenschappen |
|
immunologie |
|
genexpressie |
|
Medicine (General) |
|
Geneeskunde (algemeen) |
Bibliography |
Includes bibliographical references and index |
Notes |
English |
Subject |
Lymphocytes.
|
|
Epigenetics.
|
|
Genetic regulation.
|
|
Lymphocytes
|
|
Epigenesis, Genetic
|
|
Gene Expression Regulation
|
|
MEDICAL -- Physiology.
|
|
SCIENCE -- Life Sciences -- Human Anatomy & Physiology.
|
|
Epigenetics
|
|
Genetic regulation
|
|
Lymphocytes
|
Form |
Electronic book
|
Author |
Murre, Cornelis.
|
ISBN |
9783642241031 |
|
3642241034 |
|
3642241026 |
|
9783642241024 |
|
3642447678 |
|
9783642447679 |
|