Title Polymers in nanomedicine / volume editors, Shigeru Kunugi, Tetsuji Yamaoka ; with contributions by T. Akagi [and others]

Published Berlin : Springer, ©2012

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Description 1 online resource (xi, 281 pages) : illustrations (some color) Series Advances in polymer science, 1436-5030 ; 247 Advances in polymer science ; 247. Contents Machine generated contents note: Functional Polymer Conjugates for Medicinal Nucleic Acid Delivery / Ernst Wagner -- 1. Introduction -- 2. Functions Required Within Polyplexes for Overcoming Delivery Barriers -- 2.1. Extracellular Transport -- 2.2. Cell Targeting and Intracellular Uptake -- 2.3. Intracellular Transport -- 3. Polymer Design for Bioresponsive Activity -- 3.1. Bioresponsive Polyplex Shielding -- 3.2. Bioresponsive Lipid Bilayer Interaction -- 3.3. Bioresponsive Polyplex Stability -- 4. Therapeutic Strategies -- 4.1. Ex Vivo and Localized Therapies -- 4.2. Systemic Therapies -- 5. Conclusions -- References -- Biodegradable Nanoparticles as Vaccine Adjuvants and Delivery Systems: Regulation of Immune Responses by Nanoparticle-Based Vaccine / Mitsuru Akashi -- 1. Introduction -- 2. Preparation of Biodegradable Polymeric Nanoparticles -- 2.1. PLGA Nanoparticles -- 2.2. Amphiphilic Poly(amino acid) Nanoparticles -- 2.3. Amphiphilic Polysaccharide Nanoparticles -- 2.4. Polyion Complex Nanoparticles -- 3. Polymeric Nanoparticles for Antigen Delivery and Adjuvant -- 3.1. Preparation of Antigen-Loaded Nanoparticles -- 3.2. Delivery of Antigens Using Nanoparticles -- 3.3. Activation of Dendritic Cells by Nanoparticles -- 3.4. Gene Delivery by Polyion Complex Nanoparticles -- 4. Control of Intracellular Distribution of Nanoparticles -- 4.1. pH-Responsive Nanoparticles -- 4.2. Amphiphilic Polymers for Cytosolic Delivery -- 5. Regulation of Immune Responses by Nanoparticle-Based Vaccines -- 5.1. Induction of Immune Responses Using Amphiphilic Poly(amino acid) Nanoparticles -- 5.2. Vaccination Using Antigen-Loaded PLGA Nanoparticles -- 5.3. Effect of Particle Size on Nanoparticle-Based Vaccines -- 6. Concluding Remarks and Future Perspectives -- References -- ̂ Biodegradable Polymeric Assemblies for Biomedical Materials / Koji Nagahama Note continued: 1. Introduction -- 2. Synthesis of Biodegradable Amphiphilic Polyesters -- 2.1. Homopolymers and Random Copolymers -- 2.2. Block Copolymers -- 2.3. Graft Copolymers and Branched Polymers -- 3. Microspheres and Nanospheres -- 4. Polymer Micelles -- 5. Polymersomes -- 6. Nanogels -- 7. Supramolecular Biodegradable Systems -- 8. Biodegradable Stimuli-Responsive Systems -- 8.1. Biodegradable Temperature Responsive Systems -- 8.2. Biodegradable Injectable Polymers -- 8.3. Biodegradable Shape-Memory Polymers -- 9. Conclusion -- References -- PEGylation Technology in Nanomedicine / Yukio Nagasaki -- 1. Introduction -- 2. PEGylation Chemistry -- 2.1. Site-Specific PEGylation -- 2.2. Enzymatic PEGylation -- 2.3. Heterobifunctional PEG -- 2.4. Linear and Branched PEGs -- 2.5. Releasable PEGylation -- 3. Effect of PEGylation on Pharmaceuticals -- ̂ 3.1. Reduction of Renal Clearance -- 3.2. Molecular Recognition of PEGylated Molecules -- 3.3. PEGylation on the Surface -- 4. PEGylated Drugs -- 4.1. Small Molecules -- 4.2. Peptides, Proteins, Antibodies, and Antibody Fragments -- 4.3. Oligonucleotide-PEG Conjugates -- 4.4. PEGylated Nanoparticles -- 5. Conclusions and Future Prospects -- References -- Cytocompatible Hydrogel Composed of Phospholipid Polymers for Regulation of Cell Functions / Tomohiro Konno -- 1. Polymer Hydrogels in Cell Engineering and Tissue Engineering -- 2. Spontaneously Forming Reversible Hydrogels -- 3. Cytocompatible Polymer Hydrogels Composed of Water-Soluble Phospholipid Polymers -- 3.1. Polymer Design and Fundamental Properties -- 4. Cells in PMBV/PVA Hydrogels -- 4.1. Encapsulation Technique -- 4.2. Morphology of Cells in the Hydrogels -- 4.3. Proliferation of Encapsulated Cells -- 4.4. Control of Cell Cycle in the Hydrogel -- 5. Cell Functions in the PMBV/PVA Hydrogel Note continued: 6. Gene Expression of Cells Encapsulated in PMBV/PVA Hydrogel -- 7. Encapsulation of Stem Cells and Their Undifferentiated Character -- 8. Cell-Based Biochips Fabricated Using a PMBV/PVA Hydrogel -- 8.1. Microfluidics for Miniaturized Cell Operation -- 8.2. Fabrication and Operation of Cell-Based Biochips -- 8.3. Long-Term Viability of Cells in the Cell-Based Chip -- 8.4. Cytotoxicity Assay in the Cell-Based Chip -- 9. Conclusion and Future Perspectives -- References -- Design of Biointerfaces for Regenerative Medicine / Hiroo Iwata -- 1. Introduction -- 2. Cell Adhesion to a Model Biomaterial Surface -- 2.1. Self-Assembled Monolayer as a Model Surface -- 2.2. Cell Adhesion on Material Surfaces -- 2.3. Effect of Protein Adsorption on Cell Adhesion -- 3. Cell Culture Substrates for Specific Cell Proliferation -- 3.1. Strategy for Adherent Cultures of Neural Stem Cells -- ̂ 3.2. Oriented Immobilization of Engineered EGF -- 3.3. Proliferation of Rat NSCs on EGF-His-Immobilized Surface -- 3.4. Structural Integrity and Stability of Immobilized EGF-His -- 3.5. Spontaneous Dimerization of EGF -- 3.6. Modules for Culturing NSCs in a Closed System -- 4. Cell Surface Modifications -- 4.1. Cell Surface Modifications with Amphiphilic Polymers -- 4.2. Immobilization of Bioactive Substances on an Islet Surface -- 4.3. Encapsulation of Islets with Living Cells -- 5. Summary -- References -- Advances in Tissue Engineering Approaches to Treatment of Intervertebral Disc Degeneration: Cells and Polymeric Scaffolds for Nucleus Pulposus Regeneration / Dan T. Simionescu -- 1. Introduction -- 2. Anatomy of the Intervertebral Disc -- 3. Intervertebral Disc Biochemistry and Cell Biology -- 4. Intervertebral Disc Function and Mechanical Loading -- 5. Intervertebral Disc Degeneration -- 6. Functional Consequences of IDD Note continued: 7. Nucleus Pulposus Replacement with Polymeric Materials: A Potential Treatment Option for Symptomatic IDD -- 8. Tissue Engineering -- 8.1. Cell Sourcing for Tissue Engineering of the NP -- 8.2. Biopolymeric Scaffolds for Tissue Engineering of the NP -- 9. Animal Models of IDD -- 10. Conclusions -- References -- Functionalized Biocompatible Nanoparticles for Site-Specific Imaging and Therapeutics / Avinash C. Pandey -- 1. Introduction -- 2. Properties of Nanoparticles -- 3. Surface Modification -- 4. Surface Modifying Agents -- 4.1. Capping and Passivating Agents -- 4.2. Role of Surfactants -- 5. Synthesis of Colloidal Nanoparticles -- 6. Different Types of Nanoparticles -- 6.1. Functionalized Nanoparticles -- 6.2. Functionalized Carbon Nanotubes -- 6.3. Metal Nanoparticles -- 6.4. Semiconductor Nanoparticles -- 6.5. Magnetic Nanoparticles -- 6.6. MR Contrast Agents -- 6.7. Lanthanide-Based Nanoparticles -- 7. Targeted Drug Delivery Using Nanoparticles -- 7.1. Passive Targeting by Nanoparticles -- 7.2. Active Targeting by Nanoparticles -- 7.3. Drug-Infused Nanoparticles Stop Cancer from Spreading -- 7.4. Mechanism of Nanoparticle Internalization -- 8. Conclusion and Future Prospects -- References Summary Ernst Wagner Functional Polymer Conjugates for Medicinal Nucleic Acid Delivery Takami Akagi Masanori Baba Mitsuru Akashi Biodegradable Nanoparticles as Vaccine Adjuvants and Delivery Systems: Regulation of Immune Responses by Nanoparticle-Based Vaccine Yuichi Ohya Akihiro Takahashi Koji Nagahama Biodegradable Polymeric Assemblies for Biomedical Materials Yutaka Ikeda Yukio Nagasaki PEGylation Technology in Nanomedicine Kazuhiko Ishihara Yan Xu Tomohiro Konno Cytocompatible Hydrogel Composed of Phospholipid Polymers for Regulation of Cell Functions Yusuke Arima Koichi Kato Yuji Teramura Hiroo Iwata Design of Biointerfaces for Regenerative Medicine Jeremy J. Mercuri Dan T. Simionescu Advances in Tissue Engineering Approaches to Treatment of Intervertebral Disc Degeneration: Cells and Polymeric Scaffolds for Nucleus Pulposus Regeneration Ranu K. Dutta Prashant K. Sharma Hisatoshi Kobayashi Avinash C. Pandey Functionalized Biocompatible Nanoparticles for Site-Specific Imaging and Therapeutics Bibliography Includes bibliographical references and index Notes English Online resource; title from PDF title page (SpringerLink, viewed February 6, 2012) Subject Nanomedicine. Nanotechnology. Polymers -- therapeutic use Nanomedicine -- methods Nanomedicine Nanotechnology Science des matériaux. Chimie. Nanomedicine Nanotechnology Form Electronic book Author Kunugi, Shigeru Yamaoka, Tetsuji Akagi, T. (Takami) ISBN 3642278566 9783642278563 9788364227851 8364227858

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