| Description |
1 online resource (ix, 372 pages) : illustrations (some color) |
| Contents |
Contributors; Part I: Chronic Hepatitis C; Natural History of Chronic Hepatitis C; 1 Introduction; 2 Outcome of Acute Hepatitis C; 2.1 Clinical Course; 3 Outcome of Chronic Infection; 3.1 Retrospective Studies; 3.2 Prospective Studies; 3.3 Retrospective-Prospective Studies; 3.3.1 Studies Among Young Women; 3.3.2 Studies Among Young Children; 3.3.3 Studies of Post-Transfusion Hepatitis C; 3.3.4 Studies of Community Acquired HCV Infection; 4 Fibrosis Progression; 5 Natural History of HCV-Related Cirrhosis |
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6 Factors that Affect the Rate of Disease Progression and Outcome of Chronic Hepatitis C6.1 Host Factors; 6.1.1 Age at Infection; 6.1.2 Gender; 6.1.3 Race/Ethnicity; 6.1.4 Steatosis; 6.1.5 Non-alcoholic Steatohepatitis; 6.1.6 Insulin Resistance/Diabetes; 6.1.7 Obesity; 6.1.8 Genetics; 6.1.9 Exercise; 6.1.10 ALT; 6.2 Viral Factors; 6.2.1 Co-infection with HBV; 6.2.2 HIV; 6.2.3 HCV Genotype; 6.2.4 Viral Load; 6.3 Environmental Factors; 6.3.1 Alcohol; 6.3.2 Smoking; 6.3.3 Cannabis; 6.3.4 Caffeine; 7 Summary; References; The Multifaceted Features of HCV Infection Beyond the Liver; 1 Introduction |
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2 Manifestations Associated with HCV Infection2.1 Cryoglobulinemia; 2.2 Renal Impairments and Glomerulonephritis; 2.3 Porphyria Cutanea Tarda; 2.4 Sjögrenś Syndrome; 2.5 Diabetes and Insulin Resistance; 2.6 Lipid Metabolism Disturbances and Steatosis; 2.7 Lichen Planus; 2.8 Oral Cancer; 2.9 Malignant Lymphoma; 2.10 Autoimmune Thyroid Disease; 2.11 Idiopathic Interstitial Pneumonitis; 2.12 Myocardial Impairments; 2.13 Moorenś Ulcer; 2.14 Cognitive and Mental Disorders; 2.15 All-Cause Mortality in HCV-Seropositives; 3 Conclusion; References; Hepatic Fibrosis in Hepatitis C; 1 Introduction |
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2 Pathogenesis of Fibrosis3 Perpetuation of Liver Injury; 4 Intrahepatic Blood Flow and Fibrosis; 5 Effects of HCV Proteins on Fibrosis; 6 MicroRNAs and Fibrosis; 7 Innate Immune Response and Fibrosis; 8 Contribution of Adaptive Immunity; 9 Histologic Fibrosis; 10 Fibrosis Imaging; 11 Serum Markers of Fibrosis; 12 HCV and HIV Co-infection; 13 Contribution of Other Factors to Fibrosis; 14 Post-Transplantation Fibrosis; 15 Fibrosis Resolution; 16 Effects of HCV Treatment; 17 Anti-fibrotic Therapy; References; Hepatocellular Carcinoma and Hepatitis C Virus; 1 Epidemiology of HCV-Related HCC |
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2 The Role of HCV in Hepatocarcinogenesis2.1 Direct Role of HCV in HCC Development; 2.2 HCV Variants and HCC; 2.3 Alcohol and HCV-Related HCC; 3 Genetics of HCV-Related HCC; 3.1 Genetic Mutation and Polymorphism for HCC Susceptibility; 3.2 Profiles of Epigenetic Alterations in HCV-Related HCC; 4 Identified Mechanisms of HCV Proteins in Hepatocarcinogenesis; 4.1 HCV and Oxidative Stress; 4.2 HCV and Hepatocyte Cell Growth; 4.3 HCV and Insulin Resistance; 5 Role of Sex Hormones in HCV-Induced HCC Development; 5.1 Estrogen Axis and HCV-Related HCC; 5.2 Androgen Axis and HCV-Related HCC |
| Summary |
This book helps scientists, clinicians and other interested individuals understand recent clinical advances and challenges for the future. It covers many basic aspects of the pathogenesis of chronic hepatitis C, HCV infections in particular populations, approaches to therapy, and prevention and control of HCV Infection. The book provides a succinct review of the large amount of data generated by multiple groups over the past two decades that has revealed the natural history of HCV infection. Similarly, it summarizes current understanding of the origins of HCV-associated hepatocellular carcinoma, cirrhosis and hepatic fibrosis. Extra-hepatic manifestation and metabolic disorders related to HCV infection are described. In this volume, these clinically important aspects of HCV infection are comprehensively described. Highlights are description of newly developed direct- acting antivirals. The authors represent a worldwide distribution of leaders in the field reflecting the global nature of HCV infection. Based on recent data concerning the genetic- and geographical diversity of HCV, and increased global disease burden of HCV infection, challenges for global control of HCV infections are described |
| Notes |
Includes index |
| Bibliography |
Includes bibliographical references at the end of each chapters and index |
| Notes |
Online resource; title from PDF title page (SpringerLink, viewed November 3, 2016) |
| Subject |
Hepatitis C virus.
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Hepatitis C.
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Hepatitis C
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Hepatitis C, Chronic
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Hepacivirus
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HEALTH & FITNESS -- Diseases -- General.
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MEDICAL -- Clinical Medicine.
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MEDICAL -- Diseases.
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MEDICAL -- Evidence-Based Medicine.
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MEDICAL -- Internal Medicine.
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Hepatitis C
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Hepatitis C virus
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| Form |
Electronic book
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| Author |
Miyamura, Tatsuo, editor.
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Lemon, Stanley M., editor.
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Walker, Christopher M., editor.
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Wakita, Takaji, editor
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| ISBN |
9784431561019 |
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4431561013 |
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4431560998 |
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9784431560999 |
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