| Description |
1 online resource (ix, 104 pages) : illustrations |
| Contents |
Anti-aging mechanisms of peptides -- Estimation of peptides effect on gene expression in mouse heart using DNA-microarray technology -- Effect of peptides on IL-2 gene expression -- Effect of peptides on c-fos gene expression in stress -- Effect of peptides on carcinogenesis in transgenic mice -- Effect of peptides on chromosomes -- Effect of epitalon on telomerase activity, telomere |
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Elongation and proliferative potential in human somatic cells -- Effect of peptides on DNA synthesis -- Interaction between small peptides and DNA double helix -- From anti-aging peptide regulation to pharmacogenomics |
| Summary |
This monograph highlights the gerontological aspects of the peptide regulation of gene expression. It focuses on the mechanisms of the geroprotective action of peptides related to chromatin activation, increase in telomerase enzyme activity, and elongation of telomeres in different cells. A key role in the initiation of the biological activity of peptide is its interaction with DNA which provides genetic stability and a normalization of the age-related metabolic shifts. Study of the genetic mechanisms of peptide action suggests a new concept which most comprehensively reflects on the evolutionary biological role peptide plays in the organism. The impact of peptides on the expression and structure of genes opens a new gate for the prevention of premature aging and age-related pathology which appears to be most promising in pharmacogenomics. This monograph narrates not only the theoretical aspects and experimental data, but also outlines new approaches to the prevention of aging and age-related pathology, thus addressing a wide readership of gerontologists, geneticists, molecular biologists, biochemists, and pharmacologists alike |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Master and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002. http://purl.oclc.org/DLF/benchrepro0212 MiAaHDL |
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Print version record |
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digitized 2010 HathiTrust Digital Library committed to preserve pda MiAaHDL |
| Subject |
Peptides -- Physiological effect
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Genetic regulation.
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Aging -- Molecular aspects.
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Aging.
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Gene Expression Regulation -- physiology
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Aging
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Peptides -- physiology
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Gene Expression Regulation
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Aging
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Aging -- Molecular aspects
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Genetic regulation
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Peptides -- Physiological effect
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Altern
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Peptide
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Regulation
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Genexpression
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| Form |
Electronic book
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| Author |
Malinin, Vladimir V
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S. Karger (Firm)
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| ISBN |
9783318011937 |
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3318011932 |
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