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Book Cover
E-book
Author Earnest, Arul

Title Essentials of a Successful Biostatistical Collaboration
Published Milton : CRC Press, 2016

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Description 1 online resource (309 pages)
Series Chapman & Hall/CRC Biostatistics Series
Chapman & Hall/CRC biostatistics series.
Contents Cover; Half Title; Title Page; Copyright Page; Dedication; Table of Contents; Preface; Acknowledgement; Author; 1: Observational Study Designs; 1.1 Introduction; 1.2 Comparative Features between Cohort, Case-Control and Cross-Sectional Studies; 1.2.1 Cross-Sectional Study Design; 1.2.2 Case-Control Study Design; 1.2.3 Cohort Study Design; 1.2.4 Ecological Study Design; 1.3 Selecting the Appropriate Study Design; 1.4 Key Questions to Ask a Clinician; 1.5 Common Mistakes; 1.6 Online Tools and Resources; 1.7 A Collaborative Case Study; Study Summary; Alternative Study Designs
Key Learning PointsReferences; 2: Randomised Controlled Trials; 2.1 Introduction; 2.2 Phases and Types of Trials; 2.3 Types and Features of Randomisation; 2.4 Controls and Blinding; 2.5 Other Types of RCTs; 2.5.1 Cluster RCT; 2.5.2 Crossover Trials; 2.5.3 Stepped Wedge Cluster RCT; 2.5.4 Equivalence Trials; 2.6 Data and Safety Monitoring Board; 2.7 Choosing Outcome Measures for a Trial; 2.8 Key Questions to Ask a Clinician; 2.9 Tools and Resources; 2.10 A Collaborative Case Study; Study Summary; Alternate Method of Randomisation; Significance of Trial; Rigorous and Appropriate Analysis
Key Learning PointsReferences; 3: Form Design and Database Management; 3.1 Introduction; 3.2 Principles of Questionnaire Design; 3.2.1 Open-Ended versus Closed-Ended Questions; 3.2.2 Multiple-Response Questions; 3.2.3 Double-Barrelled Questions; 3.2.4 Wording of Questions; 3.2.5 Ordinal Scales; 3.2.6 Validation; 3.2.7 Translation; 3.3 Types of Variables and Scales of Measurement; 3.4 Finding a Suitable Database Software for Your Study; 3.5 Efficient Ways to Create and Manage an Excel Database; 3.5.1 Multiple-Response Questions; 3.5.2 Repeated Measurements; 3.5.3 Missing Data
3.5.4 Data Validation in Excel3.5.5 Limitations to Excel; 3.6 Key Questions to Ask a Clinician; 3.7 Common Mistakes to Avoid; 3.7.1 Questionnaire Design; 3.7.2 Database Design; 3.8 Tools and Resources; 3.9 A Collaborative Case Study; Key Learning Points; References; 4: Sample Size and Power Calculations; 4.1 Introduction; 4.2 Linking Hypothesis Testing and Sample Size; 4.3 Ingredients in a Sample Size Calculation; 4.3.1 Objective of the Study; 4.3.2 Type 1 Error (Level of Significance); 4.3.3 Type 2 Error (1 -- Power); 4.3.4 Variability; 4.3.5 The Effect Size
4.3.6 Two-Sided versus One-Sided Tests4.3.7 Other Considerations; 4.4 Commonly Performed Sample Size Calculations; 4.4.1 Comparing Proportions between Two Independent Groups; 4.4.2 Comparing Means between Two Independent Groups; 4.4.3 Estimating Hazard Ratios in a Survival (Time to Event) Analysis; 4.4.4 Estimating Coefficients in a Linear Regression Model; 4.4.5 Estimating Odds Ratios in a Logistic Regression Model; 4.4.6 Estimating a Kappa Coefficient in an Agreement Study; 4.4.7 Repeated Measures Analysis; 4.4.8 Cluster Randomised Trials; 4.5 Key Questions to Ask a Clinician
Notes 4.6 Common Mistakes
Bibliography Includes bibliographical references and index
Notes Print version record
Subject Clinical medicine -- Research -- Statistical methods
Sampling (Statistics)
Statistics.
Statistics as Topic
MEDICAL -- Biostatistics.
MEDICAL -- Pharmacology.
Statistics.
Clinical medicine -- Research -- Statistical methods.
Sampling (Statistics)
Form Electronic book
ISBN 9781482226997
1482226995