| Description |
1 online resource |
| Contents |
Intro -- Drug Delivery Aspects: Volume 4: Expectations and Realities of Multifunctional Drug Delivery Systems -- Copyright -- Contents -- Contributors -- Preface -- Chapter 1: Versatile hyaluronic acid nanoparticles for improved drug delivery -- 1. Introduction -- 2. Hyaluronic acid -- 2.1. Chemistry -- 2.2. Sources -- 2.3. Physiological role -- 2.4. Turnover and elimination pathways -- 3. Preparation of hyaluronic acid nanoparticles -- 3.1. Conjugate formation -- 3.2. Self-assemblies formation -- 3.3. Ionic nanocomplexes formation -- 3.4. Nanogels formation |
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4. Applications of HA nanoparticles -- 4.1. Skin applications -- 4.2. Osteoarthritis -- 4.3. Tissue engineering -- 4.4. Cancer targeting -- 4.5. Atherosclerosis -- 4.6. Ocular drug delivery -- 4.7. Insulin sensitivity and diabetes -- 4.8. Theranostic and imaging -- 5. Clinical status -- 6. Conclusion -- References -- Chapter 2: Preclinical testing-Understanding the basics first -- 1. Introduction -- 2. Preclinical studies -- 3. Regulatory aspects of preclinical studies -- 4. Preclinical testing and models used -- 4.1. In vitro assays/cell line assays -- 5. Animal models and type of tests |
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5.1. In vivo evaluation -- 5.2. Pharmacodynamics -- 5.3. Pharmacokinetic -- 5.4. Toxicology -- 5.5. Advances in the field -- 5.6. Databases -- 6. Conclusion -- References -- Chapter 3: Aqueous polymeric coatings: New opportunities in drug delivery systems -- 1. Introduction -- 2. Coating types and polymers used -- 2.1. Aqueous-based coatings for sustained drug release (cellulosic type) -- 2.1.1. Ethylcellulose -- 2.2. Aqueous-based coatings for enteric drug release -- 2.2.1. Cellulose acetate phthalate -- 2.2.2. Hydroxypropyl methylcellulose acetate -- 2.3. Acrylate-type aqueous-based coatings |
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2.3.1. Ammonio methacrylate copolymers -- 2.3.2. Ethyacrylate methylmethacrylate -- 2.3.3. Methacrylic acid copolymers for enteric drug release -- 2.4. Aqueous-based flexible polymer coatings for sustained drug release -- 2.4.1. Polyvinyl acetate -- 3. Strategies to improve storage stability -- 3.1. Optimization of curing conditions -- 3.2. Plasticizer type and content -- 3.3. Addition of high Tg polymers -- 3.4. Addition of hydrophilic excipients -- 3.5. High solids content -- 4. Solidification of self-nanoemulsifying drug delivery systems by fluid bed coating -- 5. Conclusion -- References |
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Chapter 4: Large-scale manufacturing of nanoparticles-An industrial outlook -- 1. Introduction -- 2. Nanosuspensions -- 2.1. Top-down approach -- 2.2. Bottom-up approach -- 2.3. Considerations on scale-up from lab to industrial scale -- 2.4. Large-scale manufacturing unit operation -- 3. Lipid nanoparticles -- 4. Nanoparticle characterization and analytical techniques used -- 4.1. Other characterizations -- 5. Conclusion -- References -- Chapter 5: The role of polymers and excipients in developing amorphous solid dispersions: An industrial perspective -- 1. Introduction |
| Notes |
Includes index |
| Subject |
Drug delivery systems.
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Drug Delivery Systems
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Drug delivery systems
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| Form |
Electronic book
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| Author |
Shegokar, Ranjita
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| ISBN |
9780128218501 |
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0128218509 |
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