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Title Current treatment options for Fuchs endothelial dystrophy / Claus Cursiefen, Albert S. Jun, editors
Published Cham, Switzerland : Springer, 2016

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Description 1 online resource
Contents Foreword; Contents; Chapter 1: Epidemiology and€Genetic Basis of€Fuchs Endothelial Corneal Dystrophy; 1.1 Introduction; 1.2 Epidemiology; 1.3 Genetic Basis of€FECD; 1.3.1 Causal Mutations; 1.3.1.1 TCF4; 1.3.1.2 AGBL1; 1.3.1.3 LOXHD1; 1.3.1.4 SLC4A11; 1.3.1.5 ZEB1; 1.3.2 FECD Loci Identified by Genetic Linkage Analysis; 1.3.3 COL8A2 Early Onset FECD; 1.4 Future Therapies; References; Chapter 2: MicroRNAs in€FECD: A€New Therapeutic Option?; 2.1 Introduction; 2.2 MicroRNAs: Biogenesis and€Function; 2.3 MicroRNAs in€Corneal Endothelial Disease; 2.3.1 miR-184; 2.3.2 miR-29
2.4 Clinical Potential of€miRNAs in€Corneal Endothelial Disease2.4.1 Biomarkers; 2.4.2 Therapeutic Potential; 2.5 Concluding Remarks; References; Chapter 3: Clinical Phenotypes of€Fuchs Endothelial Corneal Dystrophy (FECD), Disease Progression, Differential Diagnosis, and€Medical Therapy; 3.1 When to€Talk About€Fuchs Endothelial Corneal Dystrophy (FECD): A€Short Recourse to€History; 3.2 Clinical Phenotypes of€FECD; 3.3 Interpretation of€Morphological Examinations; 3.3.1 Noncontact Specular Microscopy; 3.3.2 Pachymetry; 3.3.3 Anterior Segment OCT; 3.3.4 In Vivo Confocal Microscopy (IVCM)
3.4 Clinical Stages and Disease Progression3.5 Differential Diagnosis; 3.5.1 Posterior Polymorphous Corneal Dystrophy (PPCD); 3.5.2 Congenital Hereditary Endothelial Dystrophy (CHED); 3.5.3 X-linked Endothelial Corneal Dystrophy (XECD); 3.5.4 PEX Keratopathy; 3.5.5 Melanin Dispersion Syndrome; 3.5.6 Pseudophakic Bullous Keratopathy; 3.5.7 Pseudoguttae; 3.6 Associations with Other Diseases; 3.6.1 Association with Anterior Basement Membrane Dystrophy; 3.6.2 Association with Keratoconus; 3.6.3 Association with Myotonic Dystrophy; 3.7 Medical Therapy; 3.7.1 Symptomatic Therapy
3.7.2 Causative Therapy3.7.2.1 Oxidative Stress; 3.7.2.2 Endoplasmic Reticulum (ER) Stress Response; 3.7.2.3 ROCK Inhibitor; 3.8 Conclusions; References; Chapter 4: Optical and Anatomic Changes in Fuchs Endothelial Dystrophy Corneas; 4.1 Introduction; 4.2 Anatomic Changes; 4.2.1 Anterior Cornea; 4.2.1.1 Epithelium; 4.2.1.2 Keratocytes and Extracellular Matrix; 4.2.1.3 Corneal Nerves and Sensation; 4.2.2 Posterior Cornea; 4.2.2.1 Descemet Membrane; 4.2.2.2 Endothelial Cells; 4.2.3 Corneal Thickness and Curvature; 4.3 Optical Changes; 4.3.1 Small-Angle Domain and High-Order Aberrations
4.3.2 Large-Angle Domain and Intraocular Forward Scatter4.4 Association Between Anatomy and Optics; 4.5 Implication on Clinical Decision-Making and Prospect; References; Chapter 5: Evolution of Posterior Lamellar Keratoplasty: PK -- DLEK -- DSEK/DSAEK -- DMEK -- DMET; 5.1 At the Start: Who Is Going to Win the Race-Lamellar or Penetrating Keratoplasty?; 5.2 After a Long Run: Penetrating Keratoplasty Takes the Lead; 5.3 At the Curve: Posterior Lamellar Techniques Trying to Catch Up; 5.4 Before the Finish: Lamellar Techniques' Relay on the Fast Track -- From DLEK to DSEK to DMEK
Summary This book provides state of the art information on modern minimally invasive lamellar transplant techniques for Fuchs endothelial dystrophy (FED), such as Descemet stripping automated endothelial keratoplasty (DSAEK) and Descemet membrane endothelial keratoplasty (DMEK). In addition to clear step-by-step descriptions of procedures, guidance is offered on donor tissue preparation, potential intra- and postoperative complications, and complication management. Future treatment options in the form of medical, cell-based approaches are also discussed. To complete the picture, relevant information is included on the pathophysiology, clinical features, and differential diagnosis of FED. This book will be of interest to all who wish to learn about the dramatic developments in corneal transplantation and medical treatment that are transforming the management of FED
Bibliography Includes bibliographical references
Notes Online resource; title from PDF title page (SpringerLink, viewed November 11, 2016)
Subject Cornea -- Diseases -- Treatment
Fuchs' Endothelial Dystrophy -- surgery
Corneal Transplantation -- methods
Minimally Invasive Surgical Procedures
MEDICAL -- Surgery -- General.
Form Electronic book
Author Cursiefen, Claus, editor
Jun, Albert S., editor
ISBN 9783319430218
3319430211