| Description |
1 online resource (viii, 311 pages) : illustrations |
| Series |
Current directions in autoimmunity, 1422-2132 ; v. 8 |
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Current directions in autoimmunity ; v. 8. 1422-2132
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| Contents |
Determinations of B cell fate in immunity and autoimmunity / Noelle, R.J.; Erickson, L.D. -- Regulatory roles for cytokine-producing B cells in infection and autoimmune disease / Lund, F.E. [and others] -- The CD19-CD21 signal transduction complex of B lymphocytes regulates the balance between health and autoimmune disease / Tedder, T.F. [and others] -- Marginal zone B cell physiology and disease / Lopes-Carvalho, T.; Kearney, J.F. -- Dendritic cells control B cell growth and differentiation / Jego, G. [and others] -- The biology of CD20 and its potential as a target for mAb therapy / Cragg, M.S. [and others] -- B lymphocyte depletion in rheumatoid arthritis / Edwards, J.C.W.; Leandro, M.J.; Cambridge, G. -- Treatment of SLE with anti-CD20 monoclonal antibody / Looney, R.J.; Anolik, J.; Sanz, I. -- The biochemistry and biology of BAFF, APRIL and their receptors / Kalled, S.L.; Ambrose, C.; Hsu, Y.-M. -- The BAFF/APRIL system / Mackay, F. [and others] -- Human B lymphocyte malignancies / Jelinek, D.F.; Darce, J.R. -- BlySfulness does not equal blissfulness in systemic lupus erythematosus / Stohl, W |
| Summary |
The understanding of B cell biology has increased and expanded enormously in the last three decades. It is now known that B cells, in addition to just differentiating into antibody-secreting cells, serve many other vital functions. For example, their roles as antigen-presenting cells and cytokine-producing cells as well as effector cells and regulatory cells are well appreciated now. Indeed, the pathologic role of B cells in many autoimmune disorders may be largely autoantibody-independent. Today, the B cell is of considerable interest not only to immunologists but also to mainstream clinicians and scientists. The current volume covers the latest information on the functions of B cells in normal and disease states, and their therapeutic antagonism. Chapters cover cutting-edge topics from the basic to the clinical, including B cells in infection and autoimmunity, CD19-CD21 signal transduction complex, marginal zone B cell physiology and disease, B cell growth and differentiation, their role in rheumatoid arthritis, SLE treatment, the BAFF/APRIL system and B lymphocyte malignancies. This book is recommended reading for cellular and molecular immunologists as well as for rheumatologists, hematologists and clinical immunologists, and all those interested in human diseases in which B cells play an important contributory role |
| Bibliography |
Includes bibliographical references and indexes |
| Notes |
Master and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002. http://purl.oclc.org/DLF/benchrepro0212 MiAaHDL |
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Print version record |
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digitized 2010 HathiTrust Digital Library committed to preserve pda MiAaHDL |
| Subject |
Autoimmunity.
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B cells.
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Autoimmune diseases.
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B-Lymphocytes -- immunology
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Autoimmunity
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B-Lymphocytes
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Autoimmune Diseases
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Autoimmune Diseases -- physiopathology
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Autoimmunity -- physiology
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Autoimmune diseases
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Autoimmunity
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B cells
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B-Lymphozyt -- Autoaggressionskrankheit.
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Autoaggressionskrankheit -- B-Lymphozyt.
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| Form |
Electronic book
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| Author |
Stohl, William
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S. Karger (Firm)
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| ISBN |
9783318011654 |
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3318011657 |
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