| Description |
1 online resource (xviii, 296 pages) : illustrations (some color) |
| Series |
2012-2013 Springer E-Books - Biomedical & Life Sciences
|
| Contents |
Clues to Morphological Diagnosis and Prognosis Evaluation. Update on Diagnostic Criteria, on Biopsy and Surgical Specimen: Preinvasive Lesions, from Epithelial Cell Hyperplasia to Carcinoma In Situ and Invasive Carcinoma -- First-Line Immuno-Phenotyping of Prostate Diseases / Massimo Mascolo, Daniela Russo and Gaetano De Rosa -- Molecular Pathology. Molecular Determinants of Cancer-Related Inflammation / Stefania Staibano -- Apoptosis and Autophagy / Francesco Merolla -- Androgen Receptor and Steroidogenesis Pathway Control / Simona Romano, Rita Bisogni and Maria Fiammetta Romano -- Neuroendocrine Differentiation in Prostate Cancer / Renato Franco, Paolo Chieffi, Sisto Perdonà, Gaetano Facchini and Michele Caraglia -- Metastatic Dissemination / Stefania Staibano -- Resistance to Castration -- Resistance to Drugs / Stefania Staibano -- Crossroads of Signaling Pathways / Stefania Staibano -- Genetic and Epigenetic Events in Prostate Cancer. Gene Polymorphisms / Maria Siano, MariaLuisa Vecchione and Gennaro Ilardi -- Expression Signature / Stefania Staibano and Angela Celetti -- Mapping Prostate Cancer Aggressiveness Loci / Maria Siano, Silvia Varricchio and Gennaro Ilardi -- Epigenetic Mechanisms: Histone Acetylation, DNA Methylation, miRNA, Chromatin Modifiers / Angela Celetti -- A Modern Approach to Therapy of Prostate Cancer: Targeting the Deadly Subset. Molecular Markers for Patient Selection and Stratification: Personalized Prognostic Predictive Models / Stefania Staibano -- Targeting Tumor Angiogenesis / Stefania Staibano and Paolo Antonio Ascierto -- Efficacy of Signal Transduction Inhibition in Advanced Prostate Cancer / Stefania Staibano -- Therapeutic Targeting of the Bone Pre-metastatic Niche / Ester Simeone, Antonio Maria Grimaldi, Paolo Antonio Ascierto and Francesco Merolla -- Counteracting Hypoxia in Radio-Resistant Metastatic Lesions / Stefania Staibano -- "Synthetic Lethality": Molecular Co-targeting to Restore the DNA Repair Mechanisms in Prostate Cancer Cells / Gennaro Ilardi and Stefania Staibano |
| Summary |
The aim of this book will be to contribute to the education of a new generation of experts in urology, molecular biology, pathology and oncology, offering them sufficient knowledge in basic and translational research to be fluency in the web of interacting networks playing a role in prostate cancer development, progression, metastasis and drug-resistance. The volume will cover the latest innovative researches in prostate cancer, with particular emphasis to the state-of-the-art analysis technologies that are essential for the accurate identification of molecular targets for disease diagnosis, molecular mechanisms of tumorigenesis, markers for susceptibility, molecular-based prognostic prevision, characterization of biomarkers of drug efficacy and drug resistance, validation of new therapeutics and diagnostics. Current advancements on the intersecting data concerning transcriptomes, proteomes, and the molecular techniques referred as "omes, will be reported and discussed |
| Notes |
Includes index |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Online resource; title from PDF title page (SpringerLink, viewed September 16, 2013) |
| Subject |
Prostate -- Cancer -- Molecular aspects
|
|
Prostatic Neoplasms
|
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HEALTH & FITNESS -- Diseases -- General.
|
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MEDICAL -- Clinical Medicine.
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MEDICAL -- Diseases.
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MEDICAL -- Evidence-Based Medicine.
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MEDICAL -- Internal Medicine.
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Prostate -- Cancer -- Molecular aspects
|
| Form |
Electronic book
|
| Author |
Staibano, Stefania, editor
|
| ISBN |
9789400771499 |
|
9400771495 |
|
9400771487 |
|
9789400771482 |
|
