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Title Translational stroke research : from target selection to clinical trials / Paul A. Lapchak, John H Zhang, editors
Published New York : Springer, ©2012

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Description 1 online resource (xxiv, 923 pages) : illustrations (some color)
Series Springer series in translational stroke research
Springer series in translational stroke research.
Contents pt. 1. Theoretical Overview -- Vascular Targets for Ischemic Stroke Treatment / Sara Morales Palomares and Marilyn J. Cipolla -- Identifying Vascular Targets to Treat Hemorrhagic Stroke / Paul A. Lapchak -- Experimental Platforms for Assessing White Matter Pathophysiology in Stroke / Ken Arai, Loc-Duyen D. Pham and Eng H. Lo -- Neuroprotection in Stroke / Aarti Sarwal, Muhammad Shazam Hussain and Ashfaq Shuaib
pt. 2. Mechanisms & Targets -- Protein Aggregation and Multiple Organelle Damage After Brain Ischemia / Chunli H. Liu, Fan Zhang, Tibor Krisrian, Brian Polster and Gary M. Fiskum, et al. -- Antioxidants and Stroke: Success and Pitfalls / Fernanda M.F. Roleira, Elisiário J. Tavares-da-Silva, Jorge Garrido and Fernanda Borges -- Caspase-Independent Stroke Targets / Ruoyang Shi, Jiequn Weng, Paul Szelemej and Jiming Kong -- Hypoxia-Inducible Factor: A New Hope to Counteract Stroke / Chunhua Chen and Changman Zhou -- Thrombin in Ischemic Stroke Targeting / Bo Chen -- Toll-Like Receptor Agonists as Antecedent Therapy for Ischemic Brain Injury: Advancing Preclinical Studies to the Nonhuman Primate / Frances Rena Bahjat, Keri B. Vartanian, G. Alexander West and Mary P. Stenzel-Poore -- Angiogenesis and Arteriogenesis as Stroke Targets / Jieli Chen and Michael Chopp -- Hematopoietic Growth Factor Family for Stroke Drug Development / Ihsan Solaroglu and Murat Digicaylioglu -- Soluble Epoxide Hydrolase as a Stroke Target / Jonathan W. Nelson and Nabil J. Alkayed -- Membrane Potential as Stroke Target / Jens P. Dreier, Maren Winkler, Dirk Wiesenthal, Michael Scheel and Clemens Reiffurth -- Hypothermia to Identify Therapeutic Targets for Stroke Treatment / Masaaki Hokari and Midori A. Yenari -- Stroke Preconditioning to Identify Endogenous Protective or Regenerative Mechanisms / Liren Qian, Prativa Sherchan and Xuejun Sun -- microRNAs in Ischemic Brain: The Fine-Tuning Specialists and Novel Therapeutic Targets / Ashutosh Dharap, Venkata P. Nakka and Raghu Vemuganti -- Neuroglobin: A Novel Target for Endogenous Neuroprotection / Zhanyang Yu, Ning Liu and Xiaoying Wang -- Characterization of Novel Neuroprotective Lipid Analogues for the Treatment of Stroke / Pamela Maher, Alain César Biraboneye and Jean-Louis Kraus -- Na+/H+ Exchangers as Therapeutic Targets for Cerebral Ischemia / Yejie Shi and Dandan Sun -- Iron as a Therapeutic Target in Intracerebral Hemorrhage: Preclinical Testing of Deferoxamine / Ya Hua, Richard F. Keep, Yuxiang Gu and Guohua Xi -- Potential Therapeutic Targets for Cerebral Resuscitation After Global Ischemia / Yan Xu -- The Splenic Response to Ischemic Stroke: Neuroinflammation, Immune Cell Migration, and Experimental Approaches to Defining Cellular Mechanisms / Christopher C. Leonardo, Hilary Seifert and Keith R. Pennypacker
pt. 3. Translational Models -- Overcoming Barriers to Translation from Experimental Stroke Models / Ludmila Belayev -- Animal Models of Stroke for Preclinical Drug Development: A Comparative Study of Flavonols for Cytoprotection / Carli L. Roulston, Sarah McCann, Robert M. Weston and Bevyn Jarrott -- Clinical Relevance in a Translational Rodent Model of Acute Ischemic Stroke: Incorporating the Biological Variability of Spontaneous Recanalization / Kama Guluma -- A Clinically Relevant Rabbit Embolic Stroke Model for Acute Ischemic Stroke Therapy Development: Mechanisms and Targets / Paul A. Lapchak -- Animal Models of Intracranial Aneurysms / Elena I. Liang, Hiroshi Makino, Yoshiteru Tada, Kosuke Wada and Tomoki Hashimoto -- Animal Models of SAH and Their Translation to Clinical SAH / Tommaso Zoerle and R. Loch Macdonald
pt. 4. De-risking of Drug Candidates -- ADME (Absorption, Distribution, Metabolism, Excretion): The Real Meaning-Avoiding Disaster and Maintaining Efficacy for Preclinical Candidates / Katya Tsaioun and Steven A. Kates -- CeeTox Analysis to De-risk Drug Development: The Three Antioxidants (NXY-059, Radicut, and STAZN) / Paul A. Lapchak
pt. 5. Therapy Delivery -- Site-Specific, Sustained-Release Drug Delivery for Subarachnoid Hemorrhage / R. Loch Macdonald -- Therapeutic Potential of Intranasal Delivery of Drugs and Cells for Stroke and Other Neurological Diseases / Heyu Chen, Caibin Sheng, Weiliang Xia and Weihai Ying
pt. 6. Therapy Development -- High-Dose Albumin for Neuroprotection in Acute Ischemic Stroke: From Basic Investigations to Multicenter Clinical Trial / Myron D. Ginsberg -- The Translation Procedure of Low-Level Laser Therapy in Acute Ischemic Stroke: A Nonpharmaceutics Noninvasive Method / Yair Lampl -- Use of Microbubbles in Acute Stroke / Marta Rubiera and Carlos A. Molina -- Transcranial High-Intensity Focused Ultrasound for Sonothrombolysis in Stroke / Thilo Hölscher, Golnaz Ahadi, Daniel Lotz, Cheryl Schendel and David Fisher, et al. -- Cellular Therapy for Ischemic Stroke / Todd Deveau, Shan Ping Yu and Ling Wei
pt. 7. Clinical Trial Design -- Repair-Based Therapies After Stroke / Steven C. Cramer -- A Critical Review of Stroke Trial Analytical Methodology: Outcome Measures, Study Design, and Correction for Imbalances / Pitchaiah Mandava, Chase S. Krumpelman, Santosh B. Murthy and Thomas A. Kent -- Metabolic Imaging in Translational Stroke Research / Krishna A. Dani and Keith W. Muir -- Computational Analysis: A Bridge to Translational Stroke Treatment / Nirmalya Ghosh, Yu Sun, Christine Turenius, Bir Bhanu and Andre Obenaus, et al. -- Innovations in Stroke Clinical Trial Design / Karen L. Furie, Michael K. Parides and Michael K. Parides
pt. 1. Theoretical overview -- pt. 2. Mechanisms and targets -- pt. 3. Translational models -- pt. 4. De-risking of drug candidates -- pt. 5. Therapy delivery -- pt. 6. Therapy development -- pt. 7. Clinical trial design
Summary Translational Stroke Research: From Target Selection to Clinical Trials is part of "Springer Series in Translational Stroke Research." Forty-three chapters from leading stroke research groups around the world select future targets and methods for stroke management such as the vasculature and white matter, protein aggregation, neuroglobin, microRNAs, oxidation, soluble epoxide hydrolase, apoptosis, hypoxia-inducible factors, thrombin, toll-like receptor, angiogenesis, membrane potentials and pumps. The book discusses methods to regulate brain temperature and the use of preconditioning in stroke. It also presents new areas of research emphasizing restoration of function with growth factors and stem cells. It provides multiple animal models of both ischemic and hemorrhagic stroke in order to translate basic preclinical findings to clinical trials with de-risking issues, therapy delivery methods such as sustained-release and intranasal delivery, and potential therapies including cell therapies, albumin, transcranial laser, microbubbles, and ultrasound. Finally, it debates clinical trial design for analytical methodology, imaging, computation, and innovations
Analysis Medicine
Neurosciences
Neurobiology
Biomedicine
biomedische wetenschappen
neurowetenschap
neuroscience
neurobiologie
Medicine (General)
Geneeskunde (algemeen)
Bibliography Includes bibliographical references and index
Notes English
Subject Cerebrovascular disease -- Research
Brain -- Congestion.
Cerebrovascular disease.
Blood-vessels -- Diseases.
Brain -- Diseases.
Cardiovascular system -- Diseases.
Central nervous system -- Diseases.
Diseases.
Nervous system -- Diseases.
Cerebrovascular Disorders
Vascular Diseases
Brain Diseases
Cardiovascular Diseases
Central Nervous System Diseases
Disease
Nervous System Diseases
Stroke
disease.
illness.
MEDICAL -- Neurology.
Nervous system -- Diseases
Diseases
Cerebrovascular disease
Central nervous system -- Diseases
Cardiovascular system -- Diseases
Brain -- Diseases
Brain -- Congestion
Blood-vessels -- Diseases
Cerebrovascular disease -- Research
Form Electronic book
Author Lapchak, Paul A
Zhang, J. H. (John H.)
ISBN 9781441995308
1441995307
1441995293
9781441995292
1280786388
9781280786389