| Description |
1 online resource (274 pages) |
| Contents |
Intro -- Foreword -- Acknowledgments -- Contents -- Contributors -- 1: An Update on the Molecular Pillars of Aging -- Introduction -- DNA: A Central Molecule of the Aging Process -- Mutations Accumulate in Nuclear and Mitochondrial DNA During Aging -- Telomere Attrition: More Than a Consequence of Cellular Replication -- The Epigenome and Its Architectural Importance -- Transcriptome Deregulation in Aging -- Proteome Findings in Aging Research -- Altered Proteostasis -- Conserved Metabolic Pathways Offer Clues to the Factors of Aging and Longevity -- mTOR -- Sirtuins -- IGF -- AMPK |
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Ischemic Stroke -- Microbiome and Age-Related Neurodegenerative Diseases -- Conclusions -- References -- 3: Molecular Aspects of Hippocampal Aging -- Introduction -- Neuronal Loss -- Gene Expression and Regulation -- Electrophysiological Alterations Upon Aging -- Calcium Dynamics and Homeostasis -- Adenosine A2A Receptors (A2AR) -- Caffeine Effects in Aging and Alzheimer's Disease -- The Neuroimmune System Upon Aging -- Conclusion -- References -- 4: Mitochondrial Function in Aging -- Introduction -- Mitochondrial Physiology -- Mitochondrial DNA (mtDNA) Role in Aging -- Mitochondrial Dynamics |
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Mitochondrial Fission -- Mitochondrial Fusion -- Mitochondrial Turnover -- Mitochondrial Biogenesis -- Mitochondrial Dynamics in Age-Related Neurodegenerative Diseases -- Mitochondrial Dynamics in Parkinson's Disease (PD) -- Mitochondrial Dynamics in Alzheimer's Disease (AD) -- Mitochondrial Dynamics in Heart and Skeletal Muscle -- Mitochondrial Metabolism in Aging -- Mitochondrial Metabolism in Aged Skeletal Muscle -- Mitochondrial Metabolism in the Aged Heart -- Mitochondrial Metabolism in the Aged Brain -- Concluding Remarks -- References |
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5: Genomic Tools Used in Molecular Clinical Aging Research -- Introduction -- Exome and Whole-Genome Sequencing -- Transcriptome Sequencing -- Single-Cell Whole-Genome Sequencing -- Sequencing the Mitochondrial Genome and the Discovery of Age-Related Alterations -- DNA Methylation Sequencing -- Analysis of Protein-DNA Interaction Genome Wide, Chip-Seq -- References -- 6: Molecular Biomarkers of Aging Studies in Humans -- Introduction -- Molecular Biomarkers for Inflammation in Aging -- Molecular Biomarkers for Oxidative Stress -- Molecular Biomarkers for Hormones in Aging -- Growth Hormone |
| Summary |
The world population is rapidly aging--it is estimated that by 1950, around 17% of the population will be elderly. In this context, aging involves several physiological, psychological and highly complex social processes that vary from one person to another. For a long time, medical care for older adults has focused on treating chronic, age-related diseases and their associated consequences. Recently, biomedical research brings a novel point of view to develop more effective interventions by targeting the aging process itself rather than separate conditions. There is a growing number of reports indicating that aging is driven by several interconnected mechanisms and biological components referred to as the molecular pillars of aging. Interfering with these mechanisms could help to treat, prevent, and understand the development of age-related diseases and associated syndromes. This book provides a clinical perspective and general update on biomedical and genetic research in aging, moving from an update in the molecular pillars of aging to a perspective of the most recent pharmacological, clinical, and diagnostic applications using genomic approaches and techniques. While this book focuses on the specifics of genetics and genomics, it also adopts a clinical perspective of geroscience, which seeks to understand the genetic, molecular and cellular mechanisms that make aging an important risk factor and, sometimes, a determining factor in the diseases and common chronic conditions of older people. Additionally, Clinical Genetics and Genomics of Aging is a significant contribution to support aging research, as it shows that collaboration across disciplines is relevant to progress in the field. As more and more people benefit from increased longevity, clinician and researchers will be empowered by this knowledge to contribute to the progress of aging research |
| Notes |
Insulin-Like Growth Factor 1 |
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Print version record |
| Subject |
Aging -- Genetic aspects.
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Medical genetics.
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Medical -- Genetics.
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Aging -- Genetic aspects
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| Form |
Electronic book
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| Author |
Gomez-Verjan, Juan Carlos
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Rivero-Segura, Nadia Alejandra
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| ISBN |
3030409554 |
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9783030409555 |
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