| Description |
1 online resource (xii, 272 pages) : illustrations (some color) |
| Contents |
Historical Perspective: The Seven Ages of Cell Death Research / David L. Vaux -- The Intrinsic Apoptotic Pathway / Xuejun Jiang -- Molecular Basis of Cell Death Programs in Mature T Cell Homeostasis / Carrie L. Lucas and Michael J. Lenardo -- Bcl-2 Family and Their Therapeutic Potential / Qian Liu, Xiaoke Chi, Brian Leber and David W. Andrews -- IAP Proteins and Their Therapeutic Potential / Domagoj Vucic -- Cell Death and Cancer / David L. Vaux -- The DNA Damage Response Mediates Apoptosis and Tumor Suppression / Katherine Baran, Diego Rodriguez and Douglas Green -- Neuronal Death Mechanisms in Development and Disease / Corey L. Cusack, Ryan P. Annis, Adam J. Kole and Mohanish Deshmukh -- The Complex Interplay Between Metabolism and Apoptosis / Kelly Lindblom and Sally Kornbluth -- Programmed Necrosis/Necroptosis: An Inflammatory Form of Cell Death / Francis Ka-Ming Chan -- Structural Perspectives on BCL-2 Family of Proteins / Evripidis Gavathiotis -- Structural Basis of Death Receptor Signaling / Jixi Li and Hao Wu |
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1. Historical Perspective : the Seven Ages of Cell Death Research -- 2. The Intrinsic Apoptotic Pathway -- 3. Molecular Basis of Cell Death Programs in Mature T Cell Homeostasis -- 4. Bcl-2 family and their therapeutic potential -- 5. IAP proteins and their therapeutic potential -- 6. Cell Death and Cancer -- 7. The DNA damage response mediates apoptosis and tumor suppression -- 8. Neuronal Death Mechanisms in Development and Disease -- 9. The Complex Interplay Between Metabolism and Apoptosis -- 10. Programmed Necrosis/Necroptosis: An Inflammatory Form of Cell Death -- 11. Structural Perspectives on BCL-2 Family of Proteins -- 12. Structural basis of death receptor signaling |
| Summary |
Beginning from centuries of anecdotal descriptions of cell death, such as those on the development of the midwife toad in 1842 by Carl Vogt, to modern-day investigations of cell death as a biological discipline, it has become accepted that cell death in multicellular organisms is a normal part of life. This book provides a comprehensive view of cell death, from its mechanisms of initiation and execution, to its implication in human disease and therapy. Physiological cell death plays critical roles in almost all aspects of biology, and the book details its roles in lymphocyte homeostasis, neuronal function, metabolism, and the DNA damage response.?When physiological cell death goes awry, diseases can arise, and cancer is presented as a central paradigm for the consequences of derangements in the interplay between cell survival and cell death. At the same time, the potential promise of targeted therapies aimed at interdicting cell death machineries are also discussed extensively. The molecular mechanisms that underlie apoptotic cell death are illustrated from the perspectives of both the intrinsic, mitochondrial apoptotic pathway and the extrinsic, death receptor pathway. Key players in these pathways, such as the Bcl2 family proteins, cytochrome c, Apaf-1, caspases, death receptor adapter proteins, and inhibitor of apoptosis proteins, are presented from both functional and structural angles. Until only a few years ago, programmed cell death has been considered essentially synonymous with apoptosis. However, we now know that programmed cell death can also take other forms such as necrosis or necroptosis, and to this end, the mechanisms that underlie programmed necrosis in development and host defense are illustrated. The past twenty plus years have seen an incredible growth of research in cell death, with one breakthrough after another, and the legacy still goes on with constant new surprises and findings. Long live cell death! |
| Notes |
Includes index |
| Bibliography |
Includes bibliographical references and index |
| Notes |
English |
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Online resource; title from PDF title page (SpringerLink, viewed November 18, 2013) |
| In |
Springer eBooks |
| Subject |
Cell death.
|
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Cell Death
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SCIENCE -- Life Sciences -- Anatomy & Physiology.
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Cell death
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| Form |
Electronic book
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| Author |
Wu, Hao, Dr., editor.
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| ISBN |
9781461493020 |
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1461493021 |
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1461493013 |
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9781461493013 |
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