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Title Cell biology of herpes viruses / Klaus Osterrieder, editor
Published Cham, Switzerland : Springer, 2017
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Description 1 online resource : illustrations
Series Advances in anatomy, embryology and cell biology, 0301-5556 ; 223
Advances in anatomy, embryology, and cell biology ; 223
Contents Preface; References; Contents; Chapter 1: Initial Contact: The First Steps in Herpesvirus Entry; 1.1 Introduction; 1.2 Attachment to Cells; 1.3 Receptor Binding; 1.3.1 gD-Binding Receptors; Herpes Simplex Viruses; Equine Herpesviruses; 1.3.2 gB-Binding Receptors; 1.3.3 gH/gL-Binding Receptors; 1.3.4 gE-Binding Receptors; 1.4 Signaling Triggered by Alphaherpesvirus Binding to Cellular Receptors; 1.5 Calcium-Signaling Pathways; 1.6 Small GTPases; 1.7 Model of Entry: Refinement; 1.8 Conclusion and Remarks; References; Chapter 2: Herpes simplex virus Membrane Fusion
2.1 Introduction2.2 Types of Fusion Mediated by HSV Glycoproteins; 2.2.1 Virus-Cell Fusion During Entry; 2.2.2 Fusion of Primary Enveloped HSV-1 with the Outer Nuclear Membrane; 2.2.3 HSV Syncytium Formation; 2.2.4 Fusion from Without; 2.2.5 Transfected Cell Fusion; 2.3 Summary and Future Directions; References; Chapter 3: Innate Immune Mechanisms and Herpes Simplex Virus Infection and Disease; 3.1 Introduction; 3.1.1 Pattern Recognition Receptors, Signaling, and Effector Pathways; 3.2 Sensing and Signaling Pathways; 3.2.1 Sensing of Virion and Infected Cell Proteins; 3.2.2 Sensing of HSV DNA
3.2.3 PYHIN (PYRIN and HIN Domain) Family Proteins3.2.4 Sensing of HSV RNA; 3.2.5 Sensing of Viral Fusion; 3.3 Cellular Effector Mechanisms; 3.4 Viral Evasion; 3.5 Mechanisms in Animal Models; 3.6 Manifestations in Humans; 3.6.1 Perspective; References; Chapter 4: The Human CMV IE1 Protein: An Offender of PML Nuclear Bodies; 4.1 Introduction; 4.2 PML-NBs and Intrinsic Immunity; 4.2.1 Architecture of PML-NBs; 4.2.2 Repression of HCMV Transcription by PML-NB Components; 4.3 PML-NBs as Co-regulatory Structures of Innate Immune Responses
4.4 IE1 as an Antagonist of Intrinsic and Innate Immune Responses4.4.1 Expression and Importance of IE1 During Lytic Infection; 4.4.2 Structure of IE1; 4.4.3 Molecular Mechanism of IE1-Mediated PML-NB Antagonization; 4.5 Summary and Outlook; References; Chapter 5: Herpesvirus Latency: On the Importance of Positioning Oneself; 5.1 Introduction; 5.2 Interaction Between Latent Viral Genomes and Chromosomal Regions; 5.2.1 Integration in the Host Cell Genome; 5.2.2 Chromosome Anchoring; 5.2.3 Centromere/Pericentromere Deposition; 5.3 Viral Genomes and PML-NBs: Janus-Faced Nuclear Bodies
5.4 PML-NB Entrapment of HSV-1 Genomes During Latency/Quiescence5.5 Conclusion; References; Chapter 6: Herpesvirus Capsid Assembly and DNA Packaging; 6.1 The Herpesvirus Virion; 6.2 Capsid Assembly; 6.3 DNA Packaging; 6.4 Model of HSV DNA Packaging; 6.5 Conclusions and Outlook; References; Chapter 7: Herpesvirus Nuclear Egress; 7.1 Overview of the Nuclear Egress Process; 7.2 The Nuclear Egress Complex (NEC); 7.3 Interaction of pUL31 and pUL34 and Localization of the Nuclear Egress Complex; 7.4 Changes in Overall Nuclear Architecture
Summary Herpes viruses are widely distributed in nature, causing disease in organisms as diverse as bivalves and primates, including humans. Each virus appears to have established a long-standing relationship with its host, and the viruses have the ability to manipulate and control the metabolism of host cells, as well as innate and adaptive antiviral immune responses. Herpes viruses maintain themselves within hosts in a latent state resulting in virus persistence for years? usually for the life span of the hosts. Herpes viruses comprise a large number of pathogens with diverse cellular targets and biological consequences of infection. What they have in common is their structure and the fact that they establish a dormant (latent) infection in their hosts that usually persists for life. The reviews here will highlight the general principles of herpes virus infection, with equal attention to overall principle and important difference. Also, the cell type- and life-style dependent differences in the establishment and maintenance of virus persistence will be covered
Bibliography Includes bibliographical references
Notes Online resource; title from PDF title page (SpringerLink, viewed May 31, 2017)
Subject Herpesviruses.
Form Electronic book
Author Osterrieder, Klaus, editor
ISBN 3319531689 (electronic bk.)
9783319531687 (electronic bk.)