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Title Prominin-1 (CD133) : new insights on stem & cancer stem cell biology / Denis Corbeil, editor
Published New York : Springer, ©2013

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Description 1 online resource
Series Advances in experimental medicine and biology ; 777
Advances in experimental medicine and biology ; 777.
Contents Part 1. Biology of Prominins -- Prominin-1 (CD133): Molecular and Cellular Features Across Species / Denis Corbeil, Jana Karbanová, Christine A. Fargeas and József Jászai -- Prominin-2 and Other Relatives of CD133 / Christine A. Fargeas -- Prominin-1-Containing Membrane Vesicles: Origins, Formation, and Utility / Anne-Marie Marzesco -- Prominent Role of Prominin in the Retina / Nagananda Gurudev, Mareike Florek, Denis Corbeil and Elisabeth Knust -- Gene Regulation of Prominin-1 (CD133) in Normal and Cancerous Tissues / Kouichi Tabu, Norihisa Bizen, Tetsuya Taga and Shinya Tanaka
Part 2. Prominin-1/CD133 And Stem Cells -- Prominin-1 (CD133) and the Cell Biology of Neural Progenitors and Their Progeny / Alex M. Sykes and Wieland B. Huttner -- CD133-Positive Hematopoietic Stem Cells: From Biology to Medicine / Rupert Handgretinger and Selim Kuçi -- New Insights into the Renal Progenitor Cells and Kidney Diseases by Studying CD133 / Benedetta Bussolati and Giovanni Camussi -- CD133 Expression Strongly Correlates with the Phenotype of Very Small Embryonic-/Epiblast-Like Stem Cells / Mariusz Z. Ratajczak, Kasia Mierzejewska, Janina Ratajczak and Magda Kucia
Part 3. Prominin-1/CD133 And The Cancer Stem Cell Hypothesis -- New Insights into the CD133 (Prominin-1) Expression in Mouse and Human Colon Cancer Cells / Alessandro Sgambato, Maddalena Corbi, Maria Svelto, Emanuele Caredda and Achille Cittadini -- Prominin-1 (CD133) Expression in the Prostate and Prostate Cancer: A Marker for Quiescent Stem Cells / Davide Pellacani, Emma E. Oldridge, Anne T. Collins and Norman J. Maitland -- Prominin-1 (CD133) Reveals New Faces of Pancreatic Progenitor Cells and Cancer Stem Cells: Current Knowledge and Therapeutic Perspectives / Yuichi Hori -- Prominin-1 (CD133) and Metastatic Melanoma: Current Knowledge and Therapeutic Perspectives / Aurelio Lorico, Javier Mercapide and Germana Rappa
Part 4. Future perspectives -- from Basic Research to Medical Application -- CD133-Positive Cells for Cardiac Stem Cell Therapy: Current Status and Outlook / Peter Donndorf and Gustav Steinhoff -- CD133+ Cells for the Treatment of Degenerative Diseases: Update and Perspectives / Mirella Meregalli, Andrea Farini, Marzia Belicchi and Yvan Torrente
Summary Since its first description fifteen years ago as a novel antigen of neural and hematopoietic stem cells, prominin-1 (alias CD133) has emerged concomitantly with stem and cancer stem cell research as an essential cell surface marker allowing identification and isolation of cells with stem cell properties. Although the physiological function of prominin-1 and the other members of prominin family remains elusive, its study has revealed new biological features regarding stem cells, cancer stem cells and photoreceptors. The latter cell type is illustrated by the association of mutations in prominin-1 (PROM1) gene with retinal degenerations including Stargardt-like macular dystrophy and retinitis pigmentosa. This book discusses these issues with contributions from leading experts in molecular and cellular biology, stem cells and tissue engineering. It also covers the potential role of prominin-1- positive stem cells in regenerative medicine, and its use as a biomarker of cancers originating from various organ systems and/or molecular target in cancer stem cell therapy. This book is an essential concise guide to the latest discoveries on prominin-1 and the applications in various medical research fields such as stem and cancer stem cells. Denis Corbeil holds a PhD in Biochemistry (University of Montreal, Canada). He is head of Tissue Engineering Laboratories, Biotechnological Centre (BIOTEC), Technische Universität Dresden, Dresden, Germany
Bibliography Includes bibliographical references and index
Notes Online resource; title from digital title page (viewed on December 14, 2012)
In Springer eBooks
Subject Glycoproteins.
Stem cells.
Glycoproteins
Stem Cells
SCIENCE -- Life Sciences -- Biochemistry.
Glycoproteins
Stem cells
Form Electronic book
Author Corbeil, Denis
LC no. 2012952155
ISBN 9781461458944
1461458943
1461458935
9781461458937