| Description |
1 online resource (ix, 541 pages) : illustrations |
| Series |
Basic and clinical oncology ; 36 |
|
Basic and clinical oncology ; 36.
|
| Contents |
The myelodysplastic syndromes : history and classification / Steensma, Bennett -- Epidemiology of MDS / Hamblin -- The cytogenetics and molecular biology of MDS / Olney, Le Beau -- Genomic approaches to MDS / Pellagatti -- The role of apoptosis in MDS / Yoshida -- The role of mitochondria in MDS / Gattermann -- Defects in iron metabolism and iron overload in MDS / Malcovati -- Therapy-related MDS and myeloid leukemia / Godley, Larson -- Diagnosis of MDS : criteria and challenges / Orazi -- Hypocellular MDS : relationship to aplastic anemia and hypocellulcar acute myeloid leukemia / Tomonaga, Hata -- Diagnostic and prognostic utility of flow cytometry in MDS / Wells, Loken -- Molecular pathogenesis of the 5q-syndrome / Boultwood, Wainscoat -- CMML and MDS-MPD overlap syndromes / Nguyen, Hanson -- MDS in children / Hasle, Niemeyer -- Prognostic factors in the assessment of patients with MDS / Aul, Giagounidis, Germing -- Therapeutic strategies : the approach to care of patients w/MDS, and criteria for treatment response / Gardin, Ades, Fenaux -- Management of cytopenias in MDS / Malcovati, Hellstroem-Lindberg, Bowen -- Immune dysregulation and the role for immunotherapy in myelodysplastic syndrome (MDS) / Hussein, Steensma -- Lenalidomide therapy in MDS / Komrokji, Giagounidis, List -- DNA methyltransferase inhibitor therapy in the treatment of MDS / Gore -- Intensive chemotherapy and stem cell transplantation in MDS / De Witte, Sanz |
| Summary |
"Written by a team of leading authorities in pathogenesis, diagnostic techniques, and clinical management strategies in myelodysplastic syndrome (MDS), this text provides a concise, easy-to-follow review of the advances in the science, classification, diagnosis, and management of the condition. An ideal source for hematologists, oncologists, and cancer researchers, this Second Edition features: a new eight-page color insert: 200 color and black-and-white illustrations: and reworked content organized into three sections: MDS epidemiology and biology; diagnosis, classification, and prognosis; and MDS therapy thoroughly updated chapters reflecting a shift from the topical focus as dictated by the evolution of the field." "New topics in the Myelodysplastic Syndrome include: del(5q) and 5q-syndrome, CMML, and MDS-MPD overlap syndrome: the reborn DNA methyltransferase inhibiting nucleoside analogs : the diagnosis of chronic myelomonocytic leukemia and other MDS cases with myeloproliferative features: the role of mitochondria and the potential importance of iron overload in MDS: global genomics approaches, such as cDNA expression arrays, array-based comparative genomic hybridization, and single nucleotide polymorphism array:s the role of abnormal mitochondrial ferritin accumulation and other mitochondrial metabolic anomalies in MDS: other disease-associated alterations, such as abnormalities of B lymphocyte populations in MDS: and three recently approved drugs: azacitidine, lenalidomide, and decitabine"--Jacket |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Print version record |
| Subject |
Myelodysplastic syndromes.
|
|
Myelodysplastic Syndromes -- physiopathology
|
|
Myelodysplastic Syndromes -- therapy
|
|
Myelodysplastic Syndromes
|
|
MEDICAL -- Endocrinology & Metabolism.
|
|
Myelodysplastic syndromes
|
| Form |
Electronic book
|
| Author |
Steensma, David P.
|
| ISBN |
1420074407 |
|
9781420074406 |
|
