| Description |
1 online resource (256 pages) : illustrations |
| Contents |
Book Cover -- Half-Title -- Title -- Copyright -- Contents -- Contributors -- Preface -- 1 Innervation of senile plaques: A link between amyloid and neurofibrillary pathology? -- Introduction -- Which lesion occurs first? Which lesion causes symptoms? -- Hypotheses to explain the area selectivity of neurofibrillary pathology -- Studying connectivity of the senile plaques in Alzheimer�s disease -- Senile plaque innervation from subcortical nuclei -- Senile plaque innervation from cortical areas -- Methods -- Neuroanatomical tracing |
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Plaque disconnection induced by non-Alzheimer�s disease-related lesionsAlzheimer�s disease and connections: Animal models -- Methodology -- Results -- Corticocortical connections are disrupted -- Subcorticocortical connections are relatively preserved -- Discussion -- Deciphering the impact of Alzheimer�s disease on brain connectivity: What is the relation between dystrophic neurites and A b -- References -- 2 Vascular factors and Alzheimer�s disease -- Introduction -- Diagnosis of Alzheimer�s disease in relation to cerebrovascular disease |
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NeuropathologyClinical diagnosis -- Cardiovascular risk factors and Alzheimer�s disease -- Hypertension -- Treatment of hypertension -- Apolipoprotein E -- Blood cholesterol -- Treatment of hypercholesterolemia -- Diabetes mellitus -- Coronary heart disease and atherosclerosis -- Putative shared pathogenetic mechanisms in Alzheimer�s disease and vascular dementia -- Oxidative stress -- Ischemia -- Blood-brain barrier dysfunction -- The renin-angiotensin system -- Lifestyle and psychological stress -- Alzheimer�s disease stimulating vascular disease |
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ConclusionAcknowledgments -- References -- 3 The role of white-matter lesions in dementia -- Introduction -- Do white-matter lesions cause or contribute to the occurrence of dementia? -- What are the contributions of white-matter lesions in specific types of mental impairment such as Alzheimer�s disease and vas -- Is there a role for white-matter lesions in mild cognitive impairment and in predicting dementia onset? -- Can white-matter lesions be considered a surrogate marker of a specific form of dementia or cognitive impairment? |
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Limitations and future directionsLocation and extension of white-matter lesions -- Role of concurrent brain lesions -- Assessment of noncognitive dysfunction linked to white-matter lesions -- Role of new magnetic resonance techniques -- Conclusions -- References -- 4 Subclassification of mild cognitive impairment in research and in clinical practice -- Introduction -- Mild cognitive impairment in population-based epidemiologic studies -- Mild cognitive impairment in specialty clinic-based observational studies |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Print version record |
| Subject |
Alzheimer's disease.
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Senile dementia.
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Alzheimer Disease
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Dementia
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HEALTH & FITNESS -- Diseases -- Alzheimer's & Dementia.
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MEDICAL -- Neurology.
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Alzheimer's disease.
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Senile dementia.
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Alzheimer's disease
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Senile dementia
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| Form |
Electronic book
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| Author |
Gauthier, Serge, 1950-
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Scheltens, Philip.
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Cummings, Jeffrey L., 1948-
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| ISBN |
0203492854 |
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9780203492857 |
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