| Description |
1 online resource (xiii, 167 pages) : illustrations |
| Series |
Advances in experimental medicine and biology ; v. 703 |
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Advances in experimental medicine and biology ; v. 703.
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| Contents |
The case for complement and inflammation in AMD : open questions / Natalia Karagianni and Anthony P. Adamis -- The role of complement in AMD / Peter F. Zipfel, Nadine Lauer, and Christine Skerka -- Multiple interactions of complement factor H with its ligands in solution : a progress report / Stephen J. Perkins [and others] -- Genetic control of complement activation in humans and age related macular degeneration / Laura A. Hecker and Albert O. Edwards -- Bisretinoids of RPE lipofuscin : trigger for complement activation in age-related macular degeneration / Janet R. Sparrow -- The role of the classical complement cascade in synapse loss during development and glaucoma / Allison M. Rosen and Beth Stevens -- A role for complement in glaucoma? / Lizhen Ren and John Danias -- The ATP-binding cassette transporter ABCA4 : structural and functional properties and role in retinal disease / Yaroslav Tsybovsky, Robert S. Molday, and Krzysztof Palczewski -- Suppression of drusen formatino by compstatin, a peptide inhibitor of complement C3 activation, on cynomolgus monkey with early-onset macular degereration / Zai-Long Chi [and others] -- A targeted inhibitor of the complement alternative pathway reduces RPE injury and angiogenesis in models of age-related macular degeneration / Bärbel Rohrer [and others] -- Complement depletion with humanized cobra venom factor in a mouse model of age-related macular degeneration / David C. Fritzinger [and others] |
| Summary |
Numerous studies have pointed to the key role of complement in the pathogenesis of retinal disease, particularly age-related macular degeneration (AMD). Reports about new gene associations and links to other physiological pathways are emerging almost on a weekly base. Several promising clinical candidates covering a wide area of potential treatment applications are in the pipelines of both industrial and academic groups. This indicates an increasing interest in complement as a therapeutic target. In view of these exciting discoveries, scientists from around the world convened at the 1st Aegean Conferences Conference on Inflammation and Retinal Disease: Complement Biology and Pathology (June 10-17, 2007) in Crete, Greece, to discuss recent advances in this rapidly-evolving field. This volume represents a collection of topics on the functions of complement in eye diseases, pathophysiology, protein structures, and complement therapeutics discussed during the conference |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Print version record |
| In |
Springer eBooks |
| Subject |
Complement (Immunology) -- Congresses
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Inflammation -- Congresses
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Retina -- Diseases -- Congresses
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Eye -- Inflammation -- Congresses
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Eye -- Diseases.
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Complement (Immunology)
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Inflammation.
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Macular Degeneration -- physiopathology
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Eye Diseases
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Complement System Proteins
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Complement System Proteins -- therapeutic use
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Glaucoma -- physiopathology
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Inflammation
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Retinal Diseases -- physiopathology
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MEDICAL -- Ophthalmology.
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HEALTH & FITNESS -- Vision.
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Biomédecine.
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Sciences de la vie.
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Eye -- Diseases
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Complement (Immunology)
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Eye -- Inflammation
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Inflammation
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Retina -- Diseases
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| Genre/Form |
proceedings (reports)
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Conference papers and proceedings
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Conference papers and proceedings.
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Actes de congrès.
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| Form |
Electronic book
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| Author |
Lambris, J. D. (John D.)
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Adamis, Anthony P. (Anthony Peter), 1958-
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Conference on Inflammation and Retinal Disease: Complement Biology and Pathology (1st : 2007 : Crete, Greece)
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| ISBN |
9781441956354 |
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1441956352 |
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