| Description |
1 online resource (xx, 450 pages) : illustrations |
| Contents |
Cover -- Half Title -- Title Page -- Copyright Page -- Table of Contents -- Contributors -- Preface -- Part I: DERMAL TOXICITY -- CHAPTER 1 Pseudo-Epidermis: An In Vitro Surrogate for the Study of Cutaneous Sulfur Mustard Toxicity -- CHAPTER 2 Refinement of an Endpoint for Measuring Skin Decontaminant Efficacy -- CHAPTER 3 An In Vitro Model for Skin Reconstruction -- CHAPTER 4 Critique of Cell Culture Methods in Skin Permeability Assessment -- CHAPTER 5 The Local Lymph Node Assay and Other Approaches to the Evaluation of Skin Sensitizing Potential -- CHAPTER 6 The Alternative to Animals for Assessing Topical Irritants Is Humans -- CHAPTER 7 Hexose Monophosphate Shunt Activity in Human Epidermal Keratinocytes Exposed to Sulfur Mustard -- CHAPTER 8 What Is Irritant Dermatitis? A Biological Approach -- CHAPTER 9 Skin[sup(2)]: An In Vitro Tissue Model for Assessment of Cutaneous Safety and Efficacy Needs -- CHAPTER 10 Biochemical and Flow Cytometric Studies of the Mechanism of Action of Sulfur Mustard Using Human Cells In Culture -- CHAPTER 11 A Multiphase Screen for the Evaluation of Topical Skin Protectants Against Chemical Warfare Agents -- Part II: DEVELOPMENTAL/REPRODUCTIVE TOXICITY -- CHAPTER 12 Induction of Low-Molecular-Weight Heat-Shock Proteins in Drosophila and Human Embryonic Lineage Cells After Teratogen Exposure -- CHAPTER 13 Using Invariants of Swimming Motion in Biotoxicity Testing via Computerized Microscopy -- CHAPTER 14 Computation of Developmental Toxicity Potential by QSTR Models in the TOPKAT Program -- CHAPTER 15 Activity Profiles of Developmental Toxicity -- CHAPTER 16 Screening of Populations of Women at Risk for Reproductive Failure Using Cultured Rodent Embryos -- CHAPTER 17 Continued Evaluation and Application of a Bioluminescent Bacterial Genotoxicity Test -- Part III: IMMUNOTOXICITY |
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CHAPTER 18 Cytokine Gene Expression and Allergic Contact Dermatitis -- CHAPTER 19 Strategies for Developing Alternative Methods to Assess Contact Allergens -- Part IV: NEUROTOXICITY -- CHAPTER 20 Astrocytes as Target Site for Neurotoxicity -- CHAPTER 21 Altered Angiotensin-Induced Drinking as a Noninvasive Behavioral Biomarker of Neonatal Glutamic Acid Neurotoxicity in the Rat -- CHAPTER 22 Cell Cultures for Screening of Antiesterase Compounds -- CHAPTER 23 Mechanistic Neurotoxicity Studies Using PC12 Cells -- CHAPTER 24 MDCK: An Epithelial Cell Line Model of the Blood-Brain Barrier and Its Response to Cholinesterase Inhibitors -- Part V: ORAL/DERMAL/OCULAR VALIDATION -- CHAPTER 25 The Blood-Perfused Pig Ear: A Potential In Vitro Alternative for Dermal Permeation and Toxicity Studies -- CHAPTER 26 Bovine Comeal Opacity and Permeability Test Validation as an Alternative to the Draize Eye Irritation Assay -- CHAPTER 27 Metabolism of Humans and Animals Compared by Organ Cultures -- CHAPTER 28 Sulfur Mustard-Increased Proteolysis in Cultured Human Cells -- CHAPTER 29 Evaluation of Two In Vitro Human Skin Equivalents (Epiderm™ and Skin[sup(2)]™ Model ZK1300) for Assessing the Skin Irritation Potential of Personal Care Products and Chemicals -- CHAPTER 30 Strategies of Applications of In Vitro Methods to the Development of Pharmaceuticals and Devices -- CHAPTER 31 A Modular Approach to Validation-A Work in Progress -- CHAPTER 32 Evaluation of the CORROSITEX Method to Determine the Corrosivity Potential of Surfactants, Surfactant-Based Formulations, Chemicals, and Mixtures -- CHAPTER 33 Comparison Study of In Vitro and In Vivo Results on Textile Fabric Extracts for Assessing Dermal Irritancy Potential to Industrial Workers -- CHAPTER 34 Validation Issues for Alternatives Testing |
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CHAPTER 35 Intra- and Interlaboratory Reproducibility of EpiDerm, an In Vitro Model for Dermal Irritancy Testing -- CHAPTER 36 Primary Human Hepatocytes as an In Vitro Toxicology System -- CHAPTER 37 Review of the Up-and-Down Method for Acute Toxicity Determination -- CHAPTER 38 Skin Partitions as a Screen for Dermal Permeability -- CHAPTER 39 Reduction of Animal Utilization in Dermal Toxicologic Studies -- CHAPTER 40 Computerized In Vitro Test for Chemical Toxicity Based on Tetrahymena Swimming Patterns -- CHAPTER 41 Renal Alterations Following Sublethal Mercury Toxicity: A Fish Model for Aquatic Environmental Contamination -- CHAPTER 42 A Nonlethal, Anesthetized Canine Model Used to Reduce the Number of Animals Required to Evaluate the Effectiveness of Pretreatment Compounds Challenged with Toxic Concentrations of Cyanide -- CHAPTER 43 Confocal Microscopy and Calcium Images of Keratinocytes Exposed to Sulfur Mustard -- CHAPTER 44 Inherited and Acquired Enzyme Defects in Multiple Chemical Sensitivity -- CHAPTER 45 An In Vitro Method for Detecting Toxicants by Changes in the Pattern of Polarized Light Scattered from Bacteria -- CHAPTER 46 Attaining a Rational Refinement and Reduction in the Use of Live Animals: Studies on Cyanide Toxicity -- CHAPTER 47 Integration of Alternative Tests into a Toxicology Research Program -- Index |
| Notes |
Expanded ed. of: Animal test alternatives. New York : M. Dekker, ©1995 |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Online resource; title from PDF title page (EBSCO, viewed July 9, 2018) |
| Subject |
Toxicity testing -- In vitro.
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MEDICAL -- Pharmacology.
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Toxicity testing -- In vitro.
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| Form |
Electronic book
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| Author |
Salem, Harry, 1929- editor.
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Katz, Sidney A., 1935- editor.
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| ISBN |
9781439805817 |
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1439805814 |
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