| Description |
1 online resource (306 pages) |
| Series |
Energy Balance and Cancer ; v. 12 |
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Energy balance and cancer ; v. 12.
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| Contents |
Preface; Contents; Contributors; Chapter 1: Adipocytes, Adipocytokines, and€Cancer; Adipose Tissue; Adipocytokines and€Cancer; Leptin; Adiponectin; Visfatin; Resistin; Apelin; Chemerin; Omentin; Nesfatin; Vaspin; Retinol-Binding Protein-4; Cytokines; Adipocytes and Tumor Metabolism; Conclusion; References; Chapter 2: Adiponectin, Obesity, and€Cancer; Introduction; Adiponectin; Adiponectin Isoforms: Structural Considerations; Adiponectin Receptors; Adiponectin Modifications: Implication for€Cancer; Adiponectin Signaling Pathways Related to€Cancer |
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Role of€Adiponectin in Tumor Initiation and€Progression Types of€Cancer Associated with€Obesity and€Decreased Adiponectin; Colorectal Cancer; Endometrial Cancer; Prostate Cancer; Breast Cancer; Gastric Cancer; Hematological Malignancies; The L/A Ratio; Adiponectin Chemopreventatives; Concluding Remarks; References; Chapter 3: Leptin in€Cancer: Epidemiology and Mechanisms; An Overview of€the€Early Studies of€Leptin and Breast Cancer; Epidemiological Studies of€Leptin and€Breast Cancer; Recent In Vitro Studies |
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Preclinical Rodent Studies Evaluating Leptin's Effects on€Mammary Tumor Development/Progression Leptin/Adiponectin Ratio; Leptin Antagonists; Leptin Advances Malignancy in€Tumor Cells via€Additional Intrinsic Mechanisms; Leptin Effects on€the€Tumor Microenvironment also Contributes to€Tumor Progression; Leptin's Role in€Inflammation, Chemotaxis, and€Adaptive Immunity Impacts the€Cancer Host's Immune Responses; Leptin and Non-breast Malignancies; Conclusions; References; Chapter 4: Leptin-Signaling Pathways as€Therapeutic Targets in€Cancer |
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Connection Between Dysregulated Leptin Levels and€Cancer Effect of€Leptin on€Cancer Progression and€Metastasis; Leptin as€a€Regulator or an€Important Participant of€Various Oncogenic Pathways; Canonical Signaling Pathways of€Leptin; Noncanonical Signaling-Functional Interactions of€Leptin with€Multiple Pathways; Leptin, Estrogen, and€Aromatase; Leptin, IGF1, Insulin, and€EGFR; Leptin, Notch, and€Wnt/Catenin Pathway; Strategies to€Inhibit Leptin Signaling; Direct Inhibition of€Leptin Signaling Using Small Molecule Inhibitors |
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Activation of€Adiponectin as€an€Indirect Strategy to€Inhibit Leptin Conclusion; References; Chapter 5: Retinol Binding Protein 4: Role in€Diabetes and€Cancer; Vitamin A: Absorption and€Metabolism; Retinoid-Binding Proteins; RBP4 and€Transport of€Retinol in€the€Circulation; Cellular Retinol-Binding Proteins; Vitamin A Uptake by Extrahepatic Tissues: RBP4 and€STRA6; RBP4 Level Is Correlated with€Obesity and€Insulin Resistance; RBP4 and€STRA6 in€Insulin Resistance: A€Mechanism of€Action; Alternative Models for€Understanding How RBP4 Induces Insulin Resistance |
| Summary |
Adipocytokines provide the circuitry by which adipose tissue communicates among its component cells which include adipocytes, stromal cells, immune cells and vascular elements, with adipose tissue depots in other locations throughout the body and with other tissues in order to regulate physiologic processes of energy intake, utilization, and distribution. Since disturbances, both qualitative and quantitative, in adipocytokine function contribute significantly to many of the comorbidities associated with obesity, including diabetes, cardiovascular disease and cancer, this volume, which discusses most of the major adipocytokines independently and collectively and their roles in normal and pathologic processes, should be useful to all individuals seeking a deeper understanding of these processes. Moreover, it provides a valuable complement to the series on Energy Balance and Cancer, in which each volume is focused on a specific aspect of this process, which now constitutes an expanding problem as the obesity pandemic continues and more of the population reaches the age where cancer is most prevalent. This volume should provide a valuable resource to all clinicians and scientists engaged in caring for susceptible patients and in exploring the relation between energy balance and cancer as well as an important platform to providing the background for research development |
| Notes |
Involvement of€RBP4 and€STRA6 in Cancer Cell Biology |
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Includes index |
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Print version record |
| Subject |
Cancer -- Molecular aspects.
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Adipose tissues.
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Bioenergetics.
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Adipose Tissue
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Oncology.
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HEALTH & FITNESS -- Diseases -- General.
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MEDICAL -- Clinical Medicine.
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MEDICAL -- Diseases.
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MEDICAL -- Evidence-Based Medicine.
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MEDICAL -- Internal Medicine.
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Adipose tissues
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Bioenergetics
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Cancer -- Molecular aspects
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| Form |
Electronic book
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| Author |
Reizes, Ofer
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Berger, Nathan A.
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| ISBN |
9783319416779 |
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3319416774 |
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