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Book Cover
Book
Author Kohane, Isaac S.

Title Microarrays for an integrative genomics / Isaac S. Kohane, Alvin T. Kho, and Atul J. Butte
Published Cambridge, Mass. ; London : MIT Press, [2003]
©2003

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Location Call no. Vol. Availability
 W'PONDS  572.86 Koh/Mfa  AVAILABLE
Description xviii, 306 pages : illustrations ; 24 cm
Series Computational molecular biology
Computational molecular biology.
Contents 1. Introduction -- 1.1. The Future Is So Bright ... -- 1.2. Functional Genomics -- 1.3. Missing the Forest for the Dendrograms -- 1.4. Functional Genomics, Not Genetics -- 1.5. Basic Biology -- 2. Experimental Design -- 2.1. The Safe Conception of a Functional Genomic Experiment -- 2.2. Gene-Clustering Dogma -- 3. Microarray Measurements to Analyses -- 3.1. Generic Features of Microarray Technologies -- 3.2. Replicate Experiments, Reproducibility, and Noise -- 3.3. Prototypical Objectives and Questions -- 3.4. Preprocessing: Filters and Normalization -- 3.5. Background on Fold -- 3.6. Dissimilarity and Similarity Measures -- 4. Genomic Data-Mining Techniques -- 4.1. Introduction -- 4.2. What Can Be Clustered in Functional Genomics? -- 4.3. What Does it Mean to Cluster? -- 4.4. Hierarchy of Bioinformatics Algorithms -- 4.5. Data Reduction and Filtering -- 4.6. Self-Organizing Maps -- 4.7. Finding Genes That Split Sets -- 4.8. Phylogenetic-Type Trees -- 4.9. Relevance Networks -- 4.10. Other Methods -- 4.11. Which Technique Should I Use? -- 4.12. Determining the Significance of Findings -- 4.13. Genetic Networks -- 5. Bio-Ontologies, Data Models, Nomenclature -- 5.1. Ontologies -- 5.2. Expressivity versus Computability -- 5.3. Ontology versus Data Model versus Nomenclature -- 5.4. Data Model Introduction -- 5.5. Nomenclature -- 5.6. Postanalysis Challenges -- 6. From Functional Genomics to Clinical Relevance -- 6.1. Electronic Medical Records -- 6.2. Standardized Vocabularies for Clinical Phenotypes -- 6.3. Privacy of Clinical Data -- 6.4. Costs of Clinical Data Acquisition -- 7. The Near Future -- 7.1. New Methods for Gene Expression Profiling -- 7.2. Respecting the Older Generation -- 7.3. Selecting Software -- 7.4. Investing in the Future of the Genomic Enterprise
Notes "Bradford book."
Bibliography Includes bibliographical references and index
Subject Gene expression -- Analysis -- Automation.
DNA.
Bioinformatics.
DNA microarrays.
Genomics -- Automation.
Author Kho, Alvin
Butte, Atul J.
LC no. 2002022663
ISBN 0262612100 paperback
026211271X :