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E-book

Title Molecular mechanisms of xeroderma pigmentosum / edited by Shamim I. Ahmad, Fumio Hanaoka
Published New York, N.Y. : Springer Science+Business Media ; Austin, Tex. : Landes Bioscience, ©2008

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Description 1 online resource (xxvii, 166 pages) : illustrations (some color)
Series Advances in experimental medicine and biology ; v. 637
Advances in experimental medicine and biology ; v. 637.
Contents Historical aspects of xeroderma pigmentosum and nucleotide excision repair / James E. Cleaver -- Clinical features of xeroderma pigmentosum / Ulrich R. Hengge and Steffen Emmert -- Xeroderma pigmentosum and skin cancer / Leela Daya-Grosjean -- XPA gene, its product and biological roles / Ulrike Camenisch and Hanspeter Nogeli -- XPB and XPD between transcription and DNA repair / Brian D. Beck, Dae-Sik Hah, and Suk-Hee Lee -- XPC: its product and biological roles / Kaoru Sugasawa -- The XPE gene of xeroderma pigmentosum : its product and biological roles / Drew Bennett and Toshiki Itoh -- XPF/ERCC4 and ERCC1 : their products and biological roles / Lisa D. McDaniel and Roger A. Schultz -- XPG: its products and biological roles / Orlando D. Schorer -- Xeroderma pigmentosum variant, XPV: its product and biological roles / Chikahide Masutani, Fumio Hanaoka, and Shamim I. Ahmad
Other proteins interacting with XP proteins / Steven M. Shell and Yue Zou -- The nucleotide excision repair of DNA in human cells and its association with xeroderma pigmentosum / Alexei Gratchev -- Roles of oxidative stress in xeroderma pigmentosum / Masaharu Hayashi -- Xeroderma pigmentosum : its overlap with trichothiodystrophy, Cockayne syndrome, and other progeroid syndromes / W. Clark Lambert, Claude E. Gagna, and Muriel W. Lambert -- Population distribution of xeroderma pigmentosum / Abdul Manan Bhutto and Sandra H. Kirk -- Progress and prospects of xeroderma pigmentosum therapy / Alain Sarasin -- Animal models of xeroderma pigmentosum / Xue-Zhi Sun [and others]
Summary To understand the molecular mechanisms of XP, XP mouse models have been used, and mice deficient in XPA, XPC, XPD, XPG, XPF, and XPA/CSB have been produced and analysed. This title includes a chapter that analyzes the world distribution of XP and shows that Japan has the highest incidence of XP and of varying complementation groups
Analysis geneeskunde
medicine
biomedische wetenschappen
biomedicine
Medicine (General)
Geneeskunde (algemeen)
Bibliography Includes bibliographical references and index
Notes Print version record
Subject Xeroderma pigmentosum -- Molecular aspects
DNA repair.
Xeroderma Pigmentosum -- genetics
DNA Repair
DNA Repair Enzymes -- genetics
DNA Repair-Deficiency Disorders -- genetics
Xeroderma Pigmentosum -- therapy
MEDICAL -- Dermatology.
Xeroderma pigmentosum -- Molecular aspects.
DNA repair.
Xeroderma Pigmentosum -- genetics.
DNA Repair Enzymes -- genetics.
DNA Repair-Deficiency Disorders -- genetics.
Xeroderma Pigmentosum -- therapy.
Sciences de la vie.
Biomédecine.
DNA repair
Form Electronic book
Author Ahmad, Shamim I.
Hanaoka, Fumio, 1946-
ISBN 9780387095998
0387095993