| Description |
1 online resource (ix, 291 pages) : illustrations (some color) |
| Series |
Endocrine development, 1421-7082 ; v. 6 |
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Endocrine development ; v. 6. 1421-7082
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| Contents |
Foreword -- Preface -- Introduction -- Normal Mineral Homeostasis -- Maternal, Fetal and Neonatal Vitamin D and Calcium Metabolism during Pregnancy and Lactation -- Vitamin D Receptor -- The Rachitic Bone -- Imaging of Rachitic Bone -- Vitamin D Deficiency Rickets -- Calcium-Deficiency Rickets -- Hypophosphatemic Rickets -- Vitamin D Biosynthesis and Vitamin D 1 -Hydroxylase Deficiency -- Hereditary 1,25-Dihydroxyvitamin D-Resistant Rickets -- Rickets in Transgenic Animals -- Rickets in Developing Countries -- Prophylactic Vitamin D Supplementation |
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Consensus Development for the Supplementation of Vitamin D in Childhood and Adolescence -- Abbreviations -- Subject Index |
| Summary |
Centuries ago, during the industrial revolution, rickets, also called 'the English disease', spread rapidly among city-dwelling poor children and became endemic due to vitamin D deficiency and insufficient access to sunlight. Nowadays it appears to be endemic again as the increase of vitamin D deficiency is paralleling the primacy of breast-feeding in Western societies. Breastfeeding, nutritional status and dark skin are the main risk factors for rickets or 'rachitis' as is the correct medical term. Rickets is a childhood disorder and the basis for understanding the disease is rooted in the concept of mineral metabolism and its control mechanisms in the growing fetus, infant and child. As it is now understood that rickets is not only caused by vitamin D deficiency, it has to be kept in mind that vitamin D and calcium deficiency is prevalent in developing countries as well as in affluent societies, where children and their mothers are not exposed to as much sunlight as they need. The rapid growth in molecular biology has been exemplified in the application of subcellular technologies to study vitamin D in human and animal models. In this volume the latest research on vitamin D and rickets is presented from different perspectives such as the interesting historical overview to bone metabolism, molecular genetics of vitamin D and conclusions for disease prevention. It will be of special interest to pediatricians, endocrinologists and health care specialists who work with children at risk for the disease |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Master and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002. http://purl.oclc.org/DLF/benchrepro0212 MiAaHDL |
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digitized 2010 HathiTrust Digital Library committed to preserve pda MiAaHDL |
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Print version record |
| Subject |
Rickets.
|
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Vitamin D -- Metabolism -- Disorders
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Vitamin D.
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Rickets
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Vitamin D
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Vitamin D
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Rickets
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Vitamin D -- Metabolism -- Disorders
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Rachitis.
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Vitamine D.
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Vitamin-D-Mangel -- Rachitis -- Aufsatzsammlung.
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Rachitis -- Vitamin-D-Mangel -- Aufsatzsammlung.
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| Form |
Electronic book
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| Author |
Hochberg, Z
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| LC no. |
2003047691 |
| ISBN |
9783318009750 |
|
331800975X |
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