| Description |
1 online resource |
| Series |
Contemporary endocrinology |
|
Contemporary endocrinology (Totowa, N.J.)
|
| Contents |
Intro; Series Editor Foreword; Preface; Contents; Contributors; Chapter 1: Vitamin D Biochemistry and Physiology; Introduction; Vitamin D Production; Vitamin D Metabolism; Transport of Vitamin D Metabolites in the Blood and Their Cellular Uptake; Vitamin D Mechanism of Action; Vitamin D Regulation of Cellular Function; Classic Vitamin D Target Tissues; Nonclassic Vitamin D Target Tissues; Regulation of Proliferation and Differentiation; Regulation of Hormone Secretion; Regulation of the Immune System; References; Chapter 2: Vitamin D and Autoimmune Diseases; Introduction; Vitamin D Deficiency |
|
Systemic Lupus ErythematosusType 1 Diabetes Mellitus; Multiple Sclerosis; Inflammatory Bowel Diseases; Rheumatoid Arthritis; Psoriasis; Other Autoimmune Diseases; Possible Underlying Mechanism; Conclusion; References; Chapter 3: Vitamin D and Infectious Diseases; Why Would Vitamin D Have an Impact on Infectious Diseases?; Historical Aspects; Cod Liver Oil; Light on Mycobacteria; Vitamin D Used in Treatment; Infections Where VD Has Been Hypothesized to Play a Role; Tuberculosis; TB Immunopathology in Relation to Vitamin D-Mediated Immunology |
|
Epidemiological Aspects: Vitamin D Status Among Patients with Active TB InfectionGenetic Aspects: Vitamin D Receptor and Susceptibility Toward TB; Intervention Studies Supplementing Patients with TB with Vitamin D; Other Respiratory Tract Infections; Intervention Studies on Respiratory Tract Infections; Methicillin-Resistant Staphylococcus aureus (MRSA) Carriage in Airways; Sepsis; Observational Studies on Vitamin D and Sepsis; Vitamin D Supplementation Trials; Human Immunodeficiency Virus; Association of Anti-retroviral Treatment (ART) and Vitamin D; Vitamin D Supplementation to HIV Infected |
|
Hepatitis C VirusAssociation of Vitamin D Deficiency with Disease Severity and Sustained Viral Response; Vitamin D Supplementation and Hepatitis; Hepatitis C and HIV Coinfection; Vitamin D as Risk Marker for Infection and Role in Antimicrobial Treatment and Prevention; References; Chapter 4: Vitamin D Hormone Action in the Endocrine Tissue: Implications for Prostate and Breast Carcinoma; Introduction; Vitamin D Metabolism; Synthesis, Degradation, and Roles and Regulation of Key Enzymes; Vitamin D Metabolism in the Prostate |
|
Transcription Regulation by VDR: Domain Structure and Roles for Ligands, DNA Response Elements, and CoregulatorsFunctional Domains of VDR and Inter-domain Allostery; Naturally Occurring VDR Ligands; Calcitriol, Calcidiol, and Secondary Bile Acids; Agonist Actions of Calcitriol and Calcidiol on VDR: Analysis by Molecular Docking; Gene Regulation by VDR: Roles for Coregulators and DNA Response Elements; Interplay of Androgen and Vitamin D in Prostate: Impacts on Cell Proliferation, Vitamin D Metabolism, and the AR Pathway; Effects on Cell Cycle Regulation and E2F1, a Key Cell Cycle Regulator |
| Summary |
While the skeletal effects of vitamin D are well-documented, the role and importance of vitamin D outside of bone health has not been well-established. Vitamin D receptors are located in nearly every tissue of the body, and low levels of vitamin D are associated with a range of various diseases. This book provides an in-depth examination of these extraskeletal effects of vitamin D and the associations between vitamin D deficiency and various disease states. Beginning with a review of the biochemistry and physiology of vitamin D, subsequent chapters investigate its relationship to autoimmune and infectious diseases, various forms of cancer, endocrine issues such as diabetes, obesity and reproductive function, cardiovascular disease and muscle weakness. Concluding chapters discuss the role of vitamin D in neurological disorders, including Alzheimer's Disease, and cognitive function. Focusing on extraskeletal effects only across a range of conditions, Extraskeletal Effects of Vitamin D will be an important resource for clinical endocrinologists and primary care physicians |
| Notes |
Includes index |
|
Online resource; title from PDF title page (SpringerLink, viewed May 2, 2018) |
| Subject |
Vitamin D.
|
|
Vitamin D in the body.
|
|
Vitamin D Deficiency -- physiopathology
|
|
Vitamin D -- physiology
|
|
Vitamin D
|
|
Dietetics & nutrition.
|
|
Endocrinology.
|
|
MEDICAL -- Physiology.
|
|
SCIENCE -- Life Sciences -- Human Anatomy & Physiology.
|
|
Vitamin D
|
|
Vitamin D in the body
|
| Form |
Electronic book
|
| Author |
Liao, Emilia Pauline, editor
|
| ISBN |
9783319737423 |
|
3319737422 |
|
