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Book Cover
Author Félétou, Michel, 1956-

Title EDHF : the complete story / Michel Félétou, Paul M. Vanhoutte
Published Boca Raton : CRC/Taylor & Francis Group, 2006


Description 1 online resource (298 pages) : illustrations
Contents Chapter 1 The Blood Vessel Wall -- chapter 2 Endothelium-Derived Mediators -- chapter 3 Endothelium-Dependent Hyperpolarizations -- chapter 4 EDHF and the Physiological Control of Blood Flow -- chapter 5 EDHF and Endothelial Dysfunction -- chapter 6 EDHF and Therapeutic Interventions -- chapter 7 Conclusions
Summary The advances made in vascular biology in the last 25 years have considerably changed the perception that one could have of the endothelial cells. Once considered as a diffusion barrier preventing the access of the blood cells to the vascular matrix, the endothelium is now recognized as playing a major role in the control of blood fluidity, platelet aggregation, and vascular tone, but also in immunology, inflammation, angiogenesis, and for serving as a metabolizing and an endocrine organ.-- from the prefaceCardiovascular diseases, so prevalent in the Western world during the twentieth century, could well become the scourge of the twenty-first century in emerging countries as well as the West. Endothelial dysfunction linked to an imbalance in the synthesis and/or release of contracting and relaxing factors is often evoked to explain the initiation of the cardiovascular pathology or its development and perpetuation. Two decades ago, when nitric oxide was demonstrated to mediate endothelium-dependent relaxations, the vascular world seemed convinced that nitric oxide was the ultimate and sole explanation for such relaxations. However not everyone agreed.EDHF: The Complete Story is the work of two leading researchers who did not accept that simple conclusion, but instead continued to search, along with others, for a deeper understanding of the ways in which endothelial cells communicate with the underlying smooth muscle to signal it to hyperpolarize. Now with most, if not all, of those ways, uncovered, the authors offer this summary as way of bringing closure to the quest.This monograph reports on the work of many researchers. It summarizes the significant recent discoveries concerning endothelium-dependent hyperpolarizations, which are likely to play a much more important role in cardiovascular physiology and pathology than was originally foreseenExtensively illustrated with original diagrams and schematics that su
Bibliography Includes bibliographical references (pages 177-277) and index
Notes Print version record
Subject Vascular endothelium.
Biological Factors -- pharmacology
Vasodilator Agents -- pharmacology
Biological Factors -- physiology
Endothelium, Vascular -- drug effects
Endothelium, Vascular -- physiopathology
Endothelium, Vascular
Vasodilator Agents
MEDICAL -- Physiology.
SCIENCE -- Life Sciences -- Human Anatomy & Physiology.
MEDICAL / Anatomy
MEDICAL / Cardiology
MEDICAL / Pharmacology
Vascular endothelium
Form Electronic book
Author Vanhoutte, Paul M
ISBN 1420023314