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Title Chemotherapy and immunotherapy in urologic oncology : a guide for the advanced practice provider / Edouard J. Trabulsi, Costas D. Lallas, Anne E. Lizardi-Calvaresi, editors
Published Cham, Switzerland : Springer, [2021]


Description 1 online resource
Contents Intro -- Foreword -- Contents -- Contributors -- Chapter 1: Introduction: Integration of APP into Urologic Oncology Practice -- Part I: Prostate Cancer -- Chapter 2: Overview and Active Surveillance of Prostate Cancer -- Introduction -- Epidemiology -- Risk Factors -- Signs and Symptoms -- PSA and Screening -- Diagnostic Evaluation -- Pathology -- Staging -- Risk Stratification -- Active Surveillance -- Bibliography -- Chapter 3: Monitoring and Managing Men Following Initial Treatment of Prostate Cancer -- Introduction -- Monitoring Categories -- Monitoring for Biochemical Recurrence
Risk Stratification and Additional Testing -- Evidence of Recurrence -- Conclusion -- References -- Chapter 4: Radical Prostatectomy and Survivorship After Radical Prostatectomy -- Radical Prostatectomy -- Survivorship after Radical Prostatectomy -- Urinary Recovery -- Sexual Recovery -- Works Cited -- Chapter 5: Multimodal Treatment Plans in Prostate Cancer -- Introduction -- Postoperative Radiation Therapy -- Genomics -- Bibliography -- Chapter 6: Radiotherapy for Prostate Cancer -- Radiotherapy Techniques -- External Beam Radiation Therapy -- Brachytherapy
Radiation Therapy Based on Prostate Cancer Staging -- Fractionation Schedules and Dosing -- Moderate Hypofractionation -- Ultrahypofractionated Regimens -- Accuracy -- Palliative Radiation Therapy -- Use of Androgen Deprivation Therapy (ADT) with Radiotherapy -- Unfavorable Intermediate-Risk Disease -- High-Risk and Very-High-Risk Disease -- Possible Side Effects -- Unique Toxicities: Recognition, Treatment, and Management -- Fatigue -- Urinary Toxicities -- Gastrointestinal Toxicities -- Sexual Dysfunction -- Stress Fractures -- Methods of Minimizing Adverse Effects
Survivorship after Radiotherapy -- Urinary Recovery -- Sexual Recovery -- Bowel Toxicity -- Secondary Malignancies -- Other Survivorship Considerations -- Assessing for Recurrence -- Conclusion -- References -- Chapter 7: Androgen Deprivation Therapy -- Introduction -- Mechanism of Action -- Regulation of Androgen Production -- Agents of Treatment -- Removal of Sources of Androgens -- Use of LHRH Agonists and GnRH Antagonists -- Antiandrogens: Nonsteroidal and Steroidal Antiandrogens -- Antiandrogen Withdrawal -- Side Effects Management -- Healthy Lifestyle -- Patient Counseling
Second-Line Hormone Manipulation -- Ketoconazole -- References -- Chapter 8: Second-Generation Androgen-Targeted Agents -- Second-Generation Androgen-Targeted Agents -- Usage, Indications, and Side Effects of Abiraterone, Enzalutamide, Apalutamide, and Darolutamide -- Abiraterone (ZYTIGA™, YONSA™) -- Enzalutamide (XTANDI™) -- Apalutamide (ERLEADA™) -- Darolutamide (NUBEQA™) -- Conclusion -- References -- Chapter 9: Chemotherapy and Prostate Cancer -- Introduction -- Metastatic Hormone-Sensitive Prostate Cancer (mHSPC) -- Metastatic Castration-Resistant Prostate Cancer (mCRPC)
Summary This book is designed to familiarize clinical practitioners in systemic therapy options and medical management of urologic malignancies including prostate cancer, bladder and upper tract urothelial carcinoma, and renal cell carcinoma. Organized by organ system, the text highlights new therapies such as novel forms of androgen deprivation, cytotoxic chemotherapy, immune check point and immunomodulatory agents, and targeted therapies. Written by experts in the field, the book also reviews current chemotherapy and immunotherapy regimens for genitourinary malignancies and discusses indications, outcomes, and toxicities, as well as clinical trial concepts. Each of the book's chapters offers a bulleted box of clinical pearls on the particular role of the APP. Chemotherapy and Immunotherapy in Urologic Oncology: A Guide for the Advanced Practice Provider is a resource for urologists, uro-radiologists, medical clinicians and family practitioners alike, familiarizing its audiences with systemic therapy regimens for urologic malignancies, as well as their expected outcomes and side effects
Notes Metastatic Neuroendocrine Carcinoma
Includes index
Subject Urinary organs -- Cancer -- Treatment
Urologic Neoplasms -- therapy
Urinary organs -- Cancer -- Treatment
Form Electronic book
Author Trabulsi, Edouard J.
Lallas, Costas D
Lizardi-Calvaresi, Anne E
ISBN 9783030520212