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Author International Diabetes Conference (5th : 1997 : Turin, Italy)

Title Molecular and cell biology of type 2 diabetes and its complications / volume editors, F. Belfiore [and others]
Published Basel ; New York : Karger, ©1998


Description 1 online resource (x, 260 pages) : illustrations
Series Frontiers in diabetes ; vol. 14
Frontiers in diabetes ; vol. 14
Contents Contents -- Preface -- Chapter I: Insulin Secretion -- Insulin Secretion in Type II Diabetes Therapeutic Approach by Novel Nutrients -- The Distinction between �Glucose Setpoint�, �Glucose Threshold� and �Glucose Sensor� Is Critical for Understanding the Role of the Pancreatic [beta]-Cell in Glucose Homeostasis -- Chapter II: Insulin Action -- The 6-Phosphofructo-2-Kinase/Fructose- 2,6-Bisphosphatase System: Regulation by Insulin and an Insulinomimetic Approach to Lowering Blood Glucose Levels
Metabolic Aspects of Glycogen Synthase Activation Its Role in the Pathogenesis of Insulin Resistance and HypoglycemiaRegulation of Glucose Oxidation and Pyruvate Dehydrogenase Activity in Human SkeletalMuscle -- Chapter III: Mechanisms of Diabetic Complications -- Glucose Phosphorylation in Non-Insulin-Sensitive Tissues -- Oxidative Stress and Cardiovascular Complications of Diabetes -- The Advanced Glycosylation End Products -- Lipoprotein Structure in Type II Diabetes -- Cellular Effects of Elevated Glucose Concentrations and Diabetic Retinopathy
A Cellular Approach to the Pathogenesis of Diabetic RetinopathyVascular Remodelling in Diabetic Retinopathy -- Advanced Glycation End Products and Loss of Pericytes in Early Diabetic Retinopathy -- Microalbuminuria and Cardiovascular Risk -- Chapter IV: Short Communications -- No Evidence of the Mitochondrial DNA(t-RNALeu(UUR)) Mutation in Unselected NIDDM Patients -- Evaluation of in vitro Function of Isolated Human Pancreatic Islets during Long-Term (4Weeks) Culture -- Genetic Approaches to the Mechanisms and Biology of Signal Transduction by Insulin and IGF-1 Receptors
Use of Recombinant Adenovirus- Mediated Gene Transfer to Study Insulin Action in 3T3L1 AdipocytesRegulation of Insulin Signaling in the Skeletal and CardiacMuscles of Diabetic Rats -- Effects of Metformin on Intestinal and Pancreatic Endocrine Secretion in Type 2 (Non-Insulin-Dependent) Diabetes -- Predictive Value of Fasting Plasma Glucose versus Post-Load Glucose in the Progression to Non-Insulin-Dependent Diabetesmellitus in Obese Subjects -- Non-Insulin-Dependent Diabetes mellitus and Liver Cirrhosis Effect of Treatment with Acarbose
High Glucose Effects on Endothelial Cell Replication in vitroIs Raised Blood Pressure during Postural Changes, Rather than Basal Hypertension, a Risk for Diabetic Retinopathy? -- Kinetic Characteristics of Glucose Phosphorylation in the Rabbit Lens -- Impaired Platelet Sensitivity to the Anti-Aggregating Effects of Adenosine in Obesity and Obese Non-Insulin-Dependent Diabetes mellitus -- Antioxidant Enzyme Activities in Retinal Microvascular Cells Are Altered by a Diabetic Environment
Summary The present volume summarizes current research on type 2 diabetes, its etiology, pathogenesis and long-term vascular and neurological consequences, with special emphasis on molecular and biochemical mechanisms. Alterations in insulin secretion are comprehensively treated, focusing on the role of glucokinase as glucose sensor. Moreover, insulin action is analyzed with regard to both nonoxidative glucose utilization and glucose oxidation. Concerning the complications in chronic diabetes, topics covered include the effects of high glucose concentration on cellular and endothelial functions and on the glucose phosphorylation rate in non-insulin-sensitive tissues. Furthermore, the role of oxidative stress and advanced glycation end products as well as the significance of alterations in lipoprotein structure are considered. Finally, the pericyte loss in retinopathy and microalbuminuria as related to cardiovascular risk are discussed. Taken as a whole, the contributions included in this book represent a large body of information that will be of great interest to diabetologists, endocrinologists and internists interested in both the basic and clinical aspects of diabetes and its complications
Bibliography Includes bibliographical references and indexes
Notes Master and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002. MiAaHDL
digitized 2010 HathiTrust Digital Library committed to preserve pda MiAaHDL
Print version record
Subject Type 2 diabetes -- Pathophysiology
Type 2 diabetes -- Molecular aspects
Type 2 diabetes -- Complications -- Pathophysiology
Type 2 diabetes -- Molecular aspects -- Complications
Diabetes Mellitus, Type 2 -- complications
Diabetes Mellitus, Type 2 -- metabolism
Insulin -- metabolism
Form Electronic book
Author Belfiore, Francesco
ISBN 9783318002720