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Title Tumor microenvironment / Peter P. Lee, Francesco M. Marincola, editors
Published Cham : Springer, [2020]


Description 1 online resource
Series Cancer treatment and research ; volume 180
Cancer treatment and research ; v. 180
Contents Preface -- Part I: Imaging of tumor microenvironment, In vivo Imaging -- New technologies to image tumors -- Part II: Immune landscapes and their biology, Systemic correlates of the tumor microenvironment -- Adaptive immunity and the tumor microenvironment -- The biology of immune active cancers and their regulatory mechanisms -- The biology of immune excluded cancers -- Immunoscore -- Part III: The tumor microenvironment and therapy, The Immune Landscape in Women Cancers -- Translational biomarkers, combination therapies and their relationship with immune landscapes -- Effects of radiation on the tumor microenvironment -- Challenges of CAR T cell therapy for solid tumors
Summary This book addresses the biological processes relevant to the immune phenotypes of cancer and their significance for immune responsiveness, based on the premise that malignant cells manipulate their surroundings through an evolutionary process that is controlled by interactions with innate immune sensors as well as the adaptive recognition of self/non-self. Checkpoint inhibitor therapy is now an accepted new form of cancer treatment. Other immuno-oncology approaches, such as adoptive cell therapy and metabolic inhibitors, have also shown promising results for specific indications. Immune resistance is common, however, limiting the efficacy of immunotherapy in many common cancer types. The reasons for such resistance are diverse and peculiar to the immune landscapes of individual cancers, and to the treatment modality used. Accordingly, approaches to circumvent resistance need to take into account context-specific genetic, biological and environmental factors that may affect the cancer immune cycle, and which can best be understood by studying the target tissue and correlated systemic immune markers. Understanding the major requirements for the evolutionary process governing human cancer growth in the immune-competent host will guide effective therapeutic choices that are tailored to the biology of individual cancers
Bibliography Includes bibliographical references
Notes Online resource; title from PDF title page (SpringerLink, viewed April 9, 2020)
Subject Tumors -- Immunological aspects.
Cancer -- Immunological aspects.
Tumor Microenvironment -- immunology
Neoplasms -- immunology
Medical -- Immunology.
Medical -- Oncology.
Cancer -- Immunological aspects
Tumors -- Immunological aspects
Form Electronic book
Author Lee, Peter P., editor
Marincola, Francesco M., editor.
ISBN 9783030388621