| Description |
1 online resource (x, 245 pages) : illustrations (some color) |
| Series |
Molecular and integrative toxicology |
|
Molecular and integrative toxicology.
|
| Contents |
1. History of TCE / Richard E. Doherty -- 2. Trichloroethylene and Autoimmunity in Human and Animal Models / Kathleen M. Gilbert -- 3. Hypersensitivity Dermatitis and Hepatitis / Tamie Nakajima -- 4. Trichloroethylene-Induced Oxidative Stress and Autoimmunity / Gangduo Wang -- 5. Brain and Behavioral Changes in Rodent Models / Ambuja S. Bale -- 6. Role of Trichloroethylene in Parkinson's Disease / Stephanie Whisnant Cash -- 7. Neuroimmune Effects of Developmental TCE Exposure / Sarah J. Blossom -- 8. Environmental Sensitivity to Trichloroethylene (TCE) in the Developing Heart / Raymond B. Runyan -- 9. Trichloroethylene and Cancer / Kathleen M. Gilbert -- 10. Epigenetic Alterations due to Trichloroethylene / Craig A. Cooney -- 11. Mathematical Modeling and Trichloroethylene / Jaime H. Ivy |
| Summary |
A comprehensive overview of the effects of trichloroethylene toxicity caused by real-life exposure levels highlighting how exposure to trichloroethylene may contribute to the etiology of several idiopathic human diseases. Discussion will focus on different kinds of modeling and how they may be used to predict functional consequences and to dissect the contribution of different mechanistic pathways, including potential mechanisms of action for trichloroethylene toxicity in different organ systems. It will explore the role of epigenetic alterations in trichloroethylene toxicity, this provides important mechanistic information and may also provide the basis for intervention therapy. Chapters will also explain how the risks from trichloroethylene exposure may be greater in certain populations based on genetic predisposition, age of exposure and co-exposure to other chemicals With contributions from international experts in the field, Trichloroethylene: Toxicity and Health Risks is an essential resource for researchers and clinicians in toxicology, immunology, medicine and public health as well as industry and government regulatory scientists involved in safety and health protection and epidemiologists, highlighting the need for interdisciplinary cooperation in solving issues of environmental toxicity |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Online resource; title from pdf information screen (Ebsco, viewed Feb. 27, 2014) |
| In |
Springer eBooks |
| Subject |
Trichloroethylene -- Toxicology
|
|
Trichloroethylene -- Physiological effect.
|
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Trichloroethylene -- Environmental aspects
|
|
Toxicology.
|
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Biochemistry.
|
|
Trichloroethylene -- toxicity
|
|
Toxicology
|
|
Biochemistry
|
|
toxicology.
|
|
medicines (material)
|
|
biochemistry.
|
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BUSINESS & ECONOMICS -- Infrastructure.
|
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SOCIAL SCIENCE -- General.
|
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Trichloroethylene -- Environmental aspects
|
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Trichloroethylene -- Physiological effect
|
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Trichloroethylene -- Toxicology
|
| Form |
Electronic book
|
| Author |
Gilbert, Kathleen M., editor
|
|
Blossom, Sarah J., editor
|
| LC no. |
2014931978 |
| ISBN |
9781447163114 |
|
1447163117 |
|
1447163109 |
|
9781447163107 |
|
