| Description |
1 online resource |
| Contents |
Volume 1 ; Title Page; Copyright Page; Contents; Contributors; Preface to the First Edition; Preface to the Fifth Edition; Tribute; List of Abbreviations; Section 1 History and Use of Hematopoietic Cell Transplantation; Chapter 1 A History of Allogeneic and Autologous HematopoieticCell Transplantation ; How it all began; History of allogeneic HCT; 1949-1956: The humoral versus the cellular hypotheses; 1956-1959: Early efforts in clinical marrow transplantation; 1955-1967: Progress in animal models of allogeneic HCT; 1968-1975: The beginning of the modern era of human marrow transplantation |
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1976-1989: Widening application of allogeneic marrow grafting for human patients1989-1999: Progress in the prevention and therapy of CMV disease. New sources of grafts for allogeneic HCT; 2000-present: Reduced intensity regimens (RIC) allow transplantation of elderly and medically infirm patients. Hematologic grafts induce tolerance for solid organ transplantation; History of autologous HCT; 1958-1964: From pre-clinical studies to first clinical transplant efforts ; 1978-1995: The beginning of an era of promising results in autologous HCT |
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1986-2004: Circulating stem cells and cloned hematopoietic growth factors1982-2001: Testing for minimal residual disease and efforts to "purge" grafts for autologous HCT; 1986-1999: High-dose chemotherapy and transplantation of autologous hematopoietic cells for patients with breast cancer ; 1993-present: Research to improve preparatory regimens and efforts to consolidate post-HCT remissions ; Conclusion; References; Chapter 2 Uses and Growth of Hematopoietic Cell Transplantation; Introduction; Changing indications for HCT; Changes in patient selection; Hematopoietic cell sources |
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Autologous transplantationAllogeneic transplantation; Transplantation regimens and supportive care; Long-term survivors; Addressing barriers to use of HCT; Assessing and improving results of HCT; References; Section 2 Scientific Basis or Hematopoietic Cell Transplantation; Section 2a Hematopoiesis and Stem Biology Transplantation; Chapter 3 Generation of Definitive Engraftable Hematopoietic Stem Cells from Human Pluripotent Stem Cells; Introduction; Generation of HSCs from ESCs; What have we learned from murine ESCs?; Derivation of HSCs from hPSCs; Derivation of hemangioblasts from hESCs |
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Derivation of blood-specific lineages from hPSCsT cells; B cells; NK cells; Macrophages; Dendritic cells; Erythroid cells; Megakaryocytes/platelets; Isolation and/or expansion of hPSC-derived HSCs; Are PSC-derived hematopoietic progenitors capable of engraftment and hematopoietic repopulation?; Transplantation of HSCs derived from mPSCs; Transplantation of HSCs derived from human PSCs; Can we generate immunologically compatible HSCs?; Creation of a global hPSC bank; Immune privileged?; Pluripotent stem cells tailor-made by reprogramming patients' somatic cells (iPS) |
| Summary |
Annotation -- Fully revised for the fifth edition, this outstanding reference on bone marrow transplantation is an essential, fieldleading resource. -- Extensive coverage of the field, from the scientific basis for stemcell transplantation to the future direction of research -- Combines the knowledge and expertise of over 170 international specialists across 106 chapters -- Includes new chapters addressing basic science experiments in stemcell biology, immunology, and tolerance -- Contains expanded content on the benefits and challenges of transplantation, and analysis of the impact of new therapies to help clinical decisionmaking -- Includes a fully searchable Wiley Digital Edition with downloadable figures, linked references, and more |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Print version record and CIP data provided by publisher |
| Subject |
Hematopoietic stem cells -- Transplantation
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Transplantation immunology.
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Hematopoietic Stem Cell Transplantation
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Transplantation Immunology
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MEDICAL -- Surgery -- Transplant.
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Transplantation immunology
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Hematopoietic stem cells -- Transplantation
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| Form |
Electronic book
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| Author |
Appelbaum, Frederick R., editor
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Forman, Stephen J., editor
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Negrin, Robert S., editor
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Antin, Joseph H., editor
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| LC no. |
2015005253 |
| ISBN |
9781118416426 |
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9781118416075 |
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1118416074 |
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1118416422 |
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