Section A, Basic machinery of transcription. RNA polymerase II transcription machinery -- Regulatory transcription factors and cis-regulatory regions -- Chromatin structure and regulation of transcription -- DNA binding by transcription factors -- Section B, Cell regulatory systems. Regulation of transcription during the cell cycle -- Regulation of transcription by extracellular signals -- Section C, Systemic regulation. Transcriptional regulation of early lymphohocyte development -- Transcriptional integration of hormone and metabolic signals by nuclear receptors -- Developmental control by Hox transcriptional regulators and their cofactors -- Tissue-specific regulation by transcription factors -- Neural transcription factors -- Abnormal transcription factors produced by chromosome translocations in human cancer
Summary
Transcription factors are important in regulating gene expression, and their analysis is of paramount interest to molecular biologists studying this area. This book looks at the basic machinery of the cell involved in transcription in eukaryotes and the f
