| Description |
1 online resource (158 pages) : illustrations (some color) |
| Series |
Molecular biology intelligence unit |
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Molecular biology intelligence unit (Unnumbered)
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| Contents |
Sonic hedgehog signalling in dorsal midline and neural development / Silvia L. López and Andrés E. Carrasco -- Role of hedgehog and Gli signalling in telencephalic development / Paulette A. Zaki, Ben Martynoga, and David J. Price -- Role of Shh and Gli signalling in oligodendroglial development / Min Tan, Yingchuan Qi, and Mengsheng Qiu -- The role of sonic hedgehog signalling in craniofacial development / Dwight Cordero, Minal Tapadia, and Jill A. Helms -- Multiple roles for hedgehog signalling in zebrafish eye development / Deborah L. Stenkamp -- Sonic hedgehog signalling during tooth morphogenesis / Martyn T. Cobourne, Isabelle Miletich, and Paul T. Sharpe |
|
Limb pattern formation: upstream and downstream of Shh signalling / Aimée Zuniga and Antonella Galli -- Sonic hedgehog signalling in the developing and regenerating fins of zebrafish / Fabien Avaron, Amanda Smith, and Marie-Andrée Akimenko -- Hedgehog signalling in T-lymphocyte development / Susan Outram, Ariadne L. Hager-Theodorides, and Tessa Crompton -- Hedgehog signalling in prostate morphogenesis / Marilyn L.G. Lamm and Wade Bushman -- Sonic hedgehog signalling in visceral organ development / Huimin Zhang, Ying Litingtung, and Chin Chiang -- Shh/Gli signalling during murine lung development / Martin Rutter and Martin Post -- New perspectives in Shh signalling? / Carolyn E. Fisher |
| Summary |
He hedgehog signalling pathway is highly conserved and seen in organisms ranging from Drosophila to humans. This pathway is Tcritical in determining cell fate decisions in a variety of different cell types. There are several vertebrate analogues of the Drosophila hedgehog protein of which the most widely studied is Sonic hedgehog (Shh). Shh signalling classically involves the Gli family of zinc-fmger transcription factors. The Shh signalling pathway is well characterised in the develop ment of a number of vertebrate organ systems. It could indeed be argued that the Shh and Gli signalling may well be involved at some stage in the development of all the major organ systems in vertebrates. This volume rep resents a concerted drive to bring together *state of the art' reviews by lead ing experts in the field of Shh and Gli signalling in development from all over the world. The chapters span vertebrate organisms from zebrafish to humans and cover development of the multiple organ systems in which the Shh signalling pathway is crucial for normal development. There are chap ters on the development of the central nervous system, skeletal struc tures, visceral organs, prostate, lung, immune system and the structures of the human face. The authors themselves span three major continents and multiple nationalities which admirably illustrates the worldwide nature of the science |
| Bibliography |
Includes bibliographical references and index |
| Subject |
Morphogenesis -- Molecular aspects.
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Transcription factors.
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Cellular signal transduction.
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Developmental genetics.
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Embryonic Induction -- physiology
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Organogenesis -- physiology
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Signal Transduction -- physiology
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Transcription Factors -- genetics
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Transcription Factors
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Signal Transduction
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SCIENCE -- Life Sciences -- Developmental Biology.
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Cellular signal transduction.
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Developmental genetics.
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Embryonic Induction -- physiology.
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Organogenesis -- physiology.
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Signal Transduction -- physiology.
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Transcription Factors -- genetics.
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Morphogenesis -- Molecular aspects.
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Transcription factors.
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Biomédecine.
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Sciences de la vie.
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Cellular signal transduction
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Developmental genetics
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Morphogenesis -- Molecular aspects
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Transcription factors
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| Form |
Electronic book
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| Author |
Fisher, Carolyn E.
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Howie, Sarah E. M.
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| LC no. |
2006025296 |
| ISBN |
0387399569 |
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9780387399560 |
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9780387399577 |
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0387399577 |
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6611378030 |
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9786611378035 |
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