| Description |
1 online resource (xviii, 845 pages) : illustrations |
| Contents |
Historical Overview. Tumor Angiogenesis: from Bench to Bedside / Judah Folkman -- Mechanisms. Vasculogenesis and Angiogenesis in Development / Anne Eichmann, Karine Bouvrée, and Luc Pardanaud ; Guidance of Vascular and Neuronal Network Formation / Carmen Ruiz de Almodovar, Serena Zacchigna, Monica Autiero, and Peter Carmeliet ; The Angiogenic Switch in Tumorigenesis / Andreas Wicki and Gerhard Christofori ; Pathophysiology and Clinical Implications of Vascular Endothelial Growth Factor / Napoleone Ferrara ; Regulation of Angiogenesis and Vascular Homeostasis Through the Angiopoietin/Tie System / Hellmut G. Augustin and Ulrike Fiedler ; Eph Receptors and Ephrins: Role in Vascular Development and Tumor Angiogenesis / Dana M. Brantley-Sieders and Jin Chen ; The Role of the Neuropilins and Their Associated Plexin Receptors in Tumor Angiogenesis and Tumor Progression / Gera Neufeld and Ofra Kessler ; Platelet-derived Growth Factor: Impact on Physiological and Tumor Angiogenesis / Arne Östman and Christer Betsholtz ; Hypoxia and Tumour Angiogenesis / M. Christiane Brahimi-Horn, Julie Laferriére, Nathalie Mazure, and Jacques Pouyssegur ; Hypoxia and Angiogenesis in Glioblastomas / Till Acker and Karl H. Plate ; Endogenous Inhibitors of Angiogenesis / Malin Sund and Raghu Kalluri ; Thrombospondins and Angiogenesis / Nathan V. Lee and M. Luisa Iruela-Arispe ; Molecular and Cellular Aspects of Heparanase / Neta Ilan, Liat Fux, Michael Elkin, and Israel Vlodavsky ; Vessel Maturation and Perivascular Cells / Anne M. Goodwin and Patricia A. D'Amore ; Adhesion Molecules in the Vascular Cell Cross-Talk / Ugo Cavallaro ; Homing and Differentiation of Endothelial Progenitor Cells / Carmen Urbich, Emmanouil Chavakis, and Stefanie Dimmeler ; Molecular Players in Lymphangiogenesis / Marja Lohela and Kari Alitalo ; The Relationship Between Tumors and the Lymphatics: Consequences for Metastasis / Jonathan P. Sleeman ; Inflammation and Angiogenesis: Innate Immune Cells as Modulator of Tumor Vascularization / Margareta M. Mueller ; Arteriovenous Malformation in Mice and Men / Nicole Revencu, Laurence Boon, Miikka Vikkula |
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Animal Models and Preclinical Anti-Angiogenic Studies. Vascular Endothelial Growth Factor Antibodies for Anti-angiogenic Therapy / Hans-Peter Gerber, Megan E. Baldwin, and Farbod Shojaei ; Vascular Endothelial Growth Factor Receptor Tyrosine Kinase Inhibitors for the Treatment of Cancer / Stephen R. Wedge and Juliane M. Jürgensmeier ; Vascular Endothelial Growth Factor Receptor Antibodies for Anti-Angiogenic Therapy / Peter Bohlen, Zhenping Zhu, and Daniel J. Hicklin ; Angiopoietin-2 Antagonists for Anti-Angiogenic Therapy / Paul E. Hughes, Anthony Polverino, Jonathan D. Oliner, and Richard L. Kendall ; Anti-Angiogenic Therapy with Thrombospondins / Jack Lawler ; The Use of Orthotopic Models to Validate Antivascular Therapies for Cancer / Robert R. Langley, Sun-Jin Kim, and Isaiah J. Fidler ; Vascular Tumor Targeting / Dragan Grabulovski and Dario Neri ; Molecular Imaging of Targets and Therapeutics in Tumour Angiogenesis / James P.B. O'Connor, Daniela D. Rosa, Alan Jackson, and Gordon C. Jayson ; Imaging of Tumor Angiogenesis and Antiangiogenesis / Fabian Kiessling and Martin Krix ; Visualization of Microcirculation and Anti-Angiogenic Tumor Therapy / Marcus Czabanka and Peter Vajkoczy ; Cellular Actions of Angiogenesis Inhibitors on Blood Vessels / Peter Baluk, Beverly L. Falcón, Hiroya Hashizume, Barbara Sennino, and Donald M. McDonald ; Antiangiogenic Therapy for Normalization of Tumor Vasculature and Microenvironment / Rakesh K. Jain and Dan G. Duda ; Metronomic Antiangiogenic Chemotherapy: Questions and Answers / Robert S. Kerbel, Urban Emmenegger, Shan Man, Raquel Munoz, Francesco Bertolini, and Yuval Shaked -- Anti-Angiogenic Tumor Therapy in Clinical Studies. The Development of Avastin / Robert Mass ; Clinical Development of Sorafenib (BAY 43-9006), a VEGFR and RAF Inhibitor / Dimitris Voliotis and J. Dumas ; Clinical Development of the VEGFR Signalling Inhibitor AZD2171 / Joachim Drevs and Clemens Unger ; Clinical Development of Sunitinib Malate / Isan Chen, Carlo Bello, and Zuleima Aguilar ; The EGF(R) and VEGF(R) Pathways as Combined Targets for Anti-Angiogenesis Trials in Cancer Therapy / Klaas Hoekman, Hester van Cruijsen, and Guiseppe Giaccone ; Imaging the Effect of Anti-Angiogenic Tumor Therapy in Clinical Studies / Bruno Morgan and Mark A. Horsfield ; Vandetanib (ZACTIMA; ZD6474): Preclinical and Clinical Development / Alan Barge and Anderson J. Ryan ; Integrins: Targets for Anti-Angiogenic Therapy / Oliver Kisker ; Thalidomide in Multiple Myeloma / Thomas M. Moehler, Jens Hillengass, Axel Glasmacher, Hartmut Goldschmidt ; Surrogate Markers of Angiogenesis / Valentina Raia, Patrizia Mancuso, and Francesco Bertolini ; Vascular Disrupting Agents in Cancer Therapy / Gillian M. Tozer, Chryso Kanthou, and David J. Chaplin |
| Summary |
Summarizes the pro-angiogenic factors and anti-angiogenic molecules including their mechanism of action. This book also summarizes the preclinical data arising from the experimental evaluation of anti-angiogenic and pro-angiogenic compounds in cell culture and animal models |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Print version record |
| In |
Springer eBooks |
| Subject |
Tumors -- Blood-vessels.
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Cancer -- Treatment.
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Toxicology.
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Neoplasms -- drug therapy
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Angiogenesis Inhibitors -- therapeutic use
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Neoplasms -- blood supply
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Neovascularization, Pathologic -- drug therapy
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Toxicology
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medicines (material)
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toxicology.
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MEDICAL -- Oncology.
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HEALTH & FITNESS -- Diseases -- Cancer.
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Cancer -- Treatment.
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Neoplasms -- drug therapy.
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Angiogenesis Inhibitors -- therapeutic use.
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Neoplasms -- blood supply.
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Neovascularization, Pathologic -- drug therapy.
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Tumeurs -- Vaisseaux sanguins.
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Cancer -- Traitement.
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Tumors -- Blood-vessels.
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Cancer -- Treatment
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Tumors -- Blood-vessels
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| Form |
Electronic book
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| Author |
Marmé, D. (Dieter)
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Fusenig, N. E.
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| ISBN |
9783540331773 |
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3540331778 |
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9783540331766 |
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354033176X |
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