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Title Lipoic acid : energy production, antioxidant activity and health effects / edited by Mulchand S. Patel and Lester Packer
Published Boca Raton : CRC Press/Taylor & Francis Group, ©2008


Description 1 online resource (532 pages)
Series Oxidative stress and disease ; 24
Oxidative stress and disease ; 24.
Contents A trail of research on lipoic acid / Lester J. Reed -- Lipoic acid biosynthesis / Natasha M. Nesbitt [and others] -- The search for potent a-lipoic acid derivatives: chemical and pharmacological aspects / Moriya Ben Yakir, Yehoshua Katzhendler, and Shlomo Sasson -- Novel indole lipoic acid derivatives: synthesis and their antioxidant effects / A. Selen Gurkan and Erdem Buyukbingol -- The a-keto acid dehydrogenase complexes and glycine cleavage system: their involvement in pathways of carbohydrate, protein, and fat metabolism / Robert A. Harris [and others] -- Pyruvate dehydrogenase complex regulation and lipoic acid / Lioubov Korotchkina and Mulchand S. Patel -- Role of lipoyl domains in the function and regulation of the mammalian pyruvate dehydrogenase complex / Thomas E. Roche [and others]
Inactivation and inhibition of a-ketoglutarate dehydrogenase: oxidative modulation of lipoic acid / Kenneth M. Humphries, Amy C. Nulton-Persson, and Luke I. Szweda -- Lipoate-protein ligase A: structure and function / Kazuko Fujiwara [and others] -- A review of the stability & preliminary evaluation of the plasma pharmacokinetics of R-lipoic acid & R-dihydrolipoic acid dosage forms in human plasma from healthy volunteers / D.A. Carlson [and others] -- The pharmacokinetics, metabolism and renal excretion of a-lipoic acid and its main metabolites in humans / Jens Teichert and Rainer Preiss -- Modulation of cellular redox and metabolic status by lipoic acid / Derrick Han and Lester Packer -- The redoxin connection of lipoic acid / J.A. Barcena [and others] -- Lipoic acid as an inducer of phase II detoxification enzymes through activation of Nrf2-dependent gene expression / Kate Peterson Shay, Swapna Shenvi, and Tory M. Hagen
Deficiency disorders of components of the PDH complex: E2, BP & E3 deficiencies / Jessie M. Cameron, Mary C. Maj, and Brian H. Robinson -- The relationship between primary biliary cirrhosis and lipoic acid / Carlo Selmi [and others] -- Effects of lipoic acid on insulin action in animal models of insulin resistance / Erik J. Henriksen and Stephan Jacob -- Activation of cytoprotective signaling pathways by alpha-lipoic acid / A.K. Kiemer and B. Diesel -- Selenotrisulfide derivatives of alpha lipoic acid: potential use as a novel topical antioxidant / William T. Self -- Alpha-lipoic acid: a potent mitochondrial nutrient for improving memory deficit, oxidative stress, and mitochondrial dysfunction / Jiankang Liu -- Effects of alpha-lipoic acid on AMP-activated kinase in different tissues: therapeutic implications for the metabolic syndrome / Eun Koh [and others]
Summary There has been increased interest in identifying and making use of natural and synthetic antioxidants for the prevention of disease and the slowing of aging. This volume explains alpha lipoic acid's molecular structure. It also delves into its metabolic aspects and considers its clinical potential, including its antioxidant health benefits
Bibliography Includes bibliographical references and index
Notes Master and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002. MiAaHDL
Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force. WlAbNL
Print version record
digitized 2010 HathiTrust Digital Library committed to preserve pda MiAaHDL
Subject Lipoic acid.
Lipoic acid -- Health aspects
Lipoic acid -- Therapeutic use
Thioctic Acid -- metabolism
Thioctic Acid -- pharmacology
Thioctic Acid
Thioctic Acid -- therapeutic use
MEDICAL -- Pharmacology.
Lipoic acid.
Lipoic acid -- Health aspects.
Lipoic acid -- Therapeutic use.
Form Electronic book
Author Patel, Mulchand S
Packer, Lester.
ISBN 9781420045390