Description |
1 online resource (xiv, 536 pages) : illustrations (some color) |
Contents |
From Th1/Th2 Pardigm to Th17 cells: Le Roi est Mort, Vive le Roi -- Th17 Cytokines: Characteristics, Regulation, Biological Function -- TGF-beta and Th17 cells -- A Pleiotropic Cytokine and Th17 cells -- Apoptosis and Th17 cell Differentiation -- IL-1 and Innate Immunity in the Differentiation of Th17 cells. Negative Regulation of Th17 Differentiation -- Signal Transduction in Th17 cell Differentiation -- Structure and IL-17 Receptor Signaling -- Trafficking Receptors and Migration of Th17 cell Subsets -- Plastic T cells: Recycling Effector Functions -- Human Th17 cells -- Th17 Cytokines in Primary Mucosal Immunity -- Th17 cells and IL-23 in Gut Inflammation -- The Roles of IL17A and IL17F in Mucosal Infection and Allergy -- Th17 cells in Fungal Infections -- IL-17 cells in Organ Transplantation Rejection and Tolerance -- Th17 cells, Proteins Associated with Th17 Polarization, and their Role in Graft versus Host Disease -- Interplay of Pathogenic Th1/Th17 cells and Regulatory T cells in Auto-immune Disease: A tale of Yin and Yang -- The Role of Interleukin-17 in Systemic Lupus Erythematosus -- IL-17 in B cell Biology and Systemic Lupus Erythematosus -- IL-17 and Th17 cells in Human Rheumatoid Arthritis -- The Role of IL-23/Th17 Immune Pathway in the Pathogenesis of Arthritis -- The Roles of IL-22 and its Related Family Members in the Pathogenesis of Psoriasis -- Th17 Pathway in Psoriasis and INflammatory Skin Diseases -- Th17 cells in the Tumor Micro-environment -- IL-17-producing NKT cells in Airway Inflammation -- IL-17-producing T cells in Auto-immune Disease |
Summary |
"About 25 years ago, Mosmann & Coffman introduced the TH1/TH2 paradigm of T helper cell differentiationo which helped explain many aspects of adaptive immunity from eliminating intracellular versus extracellular pathogens to induction of different types of tissue inflammation. However, TH1/TH2 paradigm could not adequately explain development of certain inflammatory responses which provided impetus for the discovery of a new subset ot T cells, called TH17 cells. After the discovery of differentiation and transcription factors for TH17 cells, it was clear that TH17 cells represent an independent subset of T cells with specific functions in eliminating certain extracellular pathogens, presumably not adequately handled by TH1 or TH2 cells. The major role of TH17 cells has been described in inducing auto-immune inflammation. The discovery of TH17 cells has expanded the TH1/TH2 paradigm, and the integration of TH17 cells with TH1 and TH2 effector cells is beginning to explain the underlying mechanisms of tissue inflammation in a number of infections and auto-immune disease settings--From Chapter one by Vijay Kuchroo"--Page 4 of cover |
Analysis |
immunologie |
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immunology |
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infectieziekten |
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infectious diseases |
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celbiologie |
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cellular biology |
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geneeskunde |
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medicine |
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volksgezondheid |
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public health |
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farmacologie |
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pharmacology |
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biomedische wetenschappen |
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biomedicine |
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Medicine (General) |
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Geneeskunde (algemeen) |
Bibliography |
Includes bibliographical references and index |
Notes |
Print version record |
Subject |
Immunology.
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Interleukin-17.
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Immunologic diseases.
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Inflammation.
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Th17 Cells -- immunology
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Immune System Diseases
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Inflammation
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Interleukin-17 -- immunology
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Allergy and Immunology
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Inflammation
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Immunologic diseases
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Interleukin-17
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Immunology
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Form |
Electronic book
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Author |
Jiang, Shuiping, Dr.
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ISBN |
9781441993717 |
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1441993711 |
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